What is Stromectol (ivermectin)?

Stromectol, also known as ivermectin, is a prescription medication used to treat certain parasitic infections in humans. It belongs to a class of drugs called anthelmintics. Stromectol works by disrupting the nervous system of parasites, effectively killing them and eliminating the infection. It is commonly prescribed to treat conditions such as river blindness (onchocerciasis) and strongyloidiasis. Stromectol is available in tablet form and is typically taken as a single dose or as directed by a healthcare professional. It is important to follow the prescribed dosage and complete the full course of treatment for optimal results. While Stromectol is generally safe, potential side effects may include dizziness, nausea, and skin rash. It is important to discuss any existing medical conditions or medications with a healthcare provider before starting medication.

STROMECTOL (Ivermectin)
Stromectol
Ivermectin
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Prescription Required.Product of Canada.Shipped from Canada.

What is Stromectol (Ivermectin)?

Stromectol (ivermectin) is a prescription antiparasitic agent used to treat roundworms and onchocerca worms that cause river blindness.

How does Stromectol work?

Stromectol is an antiparasitic agent that is taken orally to treat predominantly parasitic worm infections. It binds to nerve and muscles cells in the worms, causing paralysis and death of the worm. It is effective against roundworms when they are present in the intestines. It is also used to treat infection of onchocera  – a parasitic worm that causes river blindness – when it is in the tissue phase of its growth.

Indications

Stromectol is indicated for the treatment of parasitic worm infections from Strongyloides. Strongyloidiasis is an infection caused by the roundworm (Strongyloides stercoralis). Strongyloides infection occurs when the skin comes into direct contact with contaminated soil. The small young roundworms burrow into the skin, migrate to the lungs, burrow into the airways, and are then swallowed. Next, the worms mature in the intestines and burrow into the intestinal wall, where they begin producing eggs. Stromectol is effective against the intestinal stage of the worm.

Onchocerciasis is a tropical disease caused by an infestation of the worm Onchocerca volvulus. Repeated bites from blackflies cause infection. These flies are found next to streams and rivers in remote tropical regions. This association has led to the disease being called river blindness. Infection with the worms causes skin swelling, itching and inflammation. Eye damage is caused by multiple microscopic worms called microfilariae. These worms migrate to the cornea surface of the eye, where they cause vision loss that can become permanent. Stromectol is effective against the microfilariae form of the worm.

Dosage

For patients with strongyloidiasis of the intestinal tract, the dose of Stromectol is 200 mcg per kg and is given as a single dose. For the 3 mg tablet of Stromectol, this translates to:

  • 15 to 24 kg – 1 tablet,
  • 25 to 35 kg – 2 tablets,
  • 36 to 50 kg – 3 tablets,
  • 51 to 65 kg – 4 tablets,
  • 66 to 79 kg – 5 tablets,
  • and > 80 kg – 200 mg per kg.

For patients with onchocerciasis, the dose of Stromectol is 150 mcg per kg and is given as a single dose. For the 3 mg tablet of Stromectol, this translates to:

  • 15 to 25 kg – 1 tablet,
  • 26 to 44 kg – 2 tablets,
  • 45 to 64 kg – 3 tablets,
  • 65 to 84 kg – 4 tablets,
  • and ? 85 kg – 150 mcg per kg.

Warnings & Precautions

Skin or systemic reactions

Stromectol may cause significant skin reactions in patients with onchocerciasis. This is thought to happen because of an inflammatory response to the death of the worm microfilariae. Treatment is supportive with antihistamines and anti-inflammatory drugs.

Immunocompromised patients

Patients who are immunocompromised may require repeat treatment to control infections of roundworm.

Additional pediatric warnings

Stromectol should be used with extreme caution, or not at all, in patients younger than two years of age or less than 15 kg. This is because these patients have a blood-brain barrier that is less well developed and run the risk of developing neurotoxic effects from Stromectol.

Special Populations

Children

Stromectol has not been tested extensively in children weighing less than 15 kg. For children 15 kg or more, the dose of Stromectol is 200 mcg per kg as a single dose. Stromectol should be used with extreme caution, or not at all, in patients younger than two years of age or less than 15 kg. These patients have a blood-brain barrier that is less well developed and run the risk of developing neurotoxic effects from Stromectol.

Pregnancy

Stromectol has not been extensively studied in pregnant women. Some studies have shown that Stromectol does not appear to harm the developing fetus, but there are few well-controlled studies to support this. Avoid using Stromectol during pregnancy.

Breastfeeding

The safety of Stromectol has not been established in breastfeeding mothers. Its active ingredient (ivermectin) is found in breastmilk. Treatment with Stromectol should be avoided unless the treatment benefit outweighs the possible harm to the child.

Elderly patients

In patients 65 years and older, there is insufficient evidence to determine whether they have a different response to Stromectol than younger patients. Care should be taken to monitor treatment and patient response, particularly in those with renal failure or hepatic failure.

Contraindications

Stromectol is contraindicated in patients with hypersensitivity to Stromectol.

Side Effects

Common side effects of Stromectol include:

  • Skin rash, itching and swelling
  • Muscle pains
  • Fever
  • Dizziness
  • Nausea
  • Diarrhea
  • Headache

Less common side effects include:

  • Confusion, drowsiness, or changes in mental status
  • Eye inflammation
  • Hepatitis
  • Stevens-Johnson syndrome
  • Anaphylaxis

Overdose with Stromectol

Persons who have overdosed with Stromectol report headaches, dizziness, abdominal pain, weakness, seizures, and loss of consciousness. Treatment is supportive. Treatment of Stromectol overdose is supportive and may include intubation and ventilation.

Drug Interactions

Vitamin K antagonists (e.g., warfarin) may interact with Stromectol. In some patients taking warfarin and Stromectol, an increased International Normalized Ratio (INR) has been reported. In some cases, this has led to an increase in bleeding events.

Frequently Asked Questions

Stromectol is manufactured as a 3 mg round, flat, white tablet and comes in packages of 20 tablets.

For patients with strongyloidiasis of the intestinal tract, the dose of Stromectol is 200 mcg per kg and is given as a single dose. For the 3 mg tablet of Stromectol, this translates to:

  • 15 to 24 kg – 1 tablet,
  • 25 to 35 kg – 2 tablets,
  • 36 to 50 kg – 3 tablets,
  • 51 to 65 kg – 4 tablets,
  • 66 to 79 kg – 5 tablets,
  • and > 80 kg – 200 mg per kg.

For patients with onchocerciasis, the dose of Stromectol is 150 mcg per kg and is given as a single dose. For the 3 mg tablet of Stromectol, this translates to:

  • 15 to 25 kg – 1 tablet,
  • 26 to 44 kg – 2 tablets,
  • 45 to 64 kg – 3 tablets,
  • 65 to 84 – 4 tablets,
  • and ? 85 kg – 150 mcg per kg.

Stromectol should be taken orally. It should not be taken with food and should be swallowed with water.

Persons with severe hypersensitivity to Stromectol should not take the medication.

Stromectol is given as a single dose. In some cases, a repeat dose may need to be given after the initial treatment but will be determined by the treating doctor. Do not repeat a dose of Stromectol unless specifically instructed to do so

Common side effects of Stromectol include:

  • Skin rash, itching and swelling
  • Muscle pains
  • Fever
  • Dizziness
  • Nausea
  • Diarrhea
  • Headache

Less common side effects include:

  • Confusion, drowsiness, or changes in mental status
  • Eye inflammation
  • Hepatitis
  • Stevens-Johnson syndrome
  • Anaphylaxis

If you experience severe side effects, immediately contact your doctor or go to the nearest emergency health care facility.

Stromectol should be stored away from children. It should be stored in a dry place at room temperature, away from heat and sunlight.