Synthroid (Levothyroxine Sodium)
from$33
$186
Synthroid Levothyroxine Sodium
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Select product strength & quantity:
Prescription Required
Ships within 4-10 Business Days
Express Ships from Canada
Product of Canada

SAVE 10% on first order

with coupon code:

PGSAVE10

What is Synthroid (Levothyroxine Sodium)?

Synthroid is a synthetic thyroid hormone (levothyroxine) prescribed to replace thyroxine produced by the thyroid gland. When the thyroid gland can’t make enough thyroxine, thyroid hormone levels in the blood are decreased (hypothyroidism). This leads to reduced metabolism and can affect organ function in the body. Additionally, the thyroid hormone is important for mental and physical activity, as well as childhood development. Synthroid replaces thyroxine with levothyroxine sodium to prevent hypothyroidism symptoms.

Dosage

Synthroid should be taken orally on an empty stomach, 30 minutes to one hour before breakfast. This medication is typically taken once daily unless instructed otherwise by your doctor. The capsule form of Synthroid must be swallowed whole, without chewing, crushing, or splitting it beforehand. The tablet form is suitable for people who cannot swallow the capsule whole. Infants and children should be given the tablet crushed in 1-2 teaspoons of water. Dosage in this form should not be prepared in advance. It is best to crush the tablet and give it to the infant immediately.

Dosage is calculated based on age, weight, the severity of the medical condition, response to treatment, and laboratory results. Thyroid hormone replacement is typically taken for life. Do not stop or change the dosage of this medication without talking to your doctor first.

Storage

Synthroid should be stored at room temperature (below 25°C), out of direct sunlight, and away from moisture. Keep out of reach of children and pets. Do not use expired medication, dispose of all expired or surplus medication responsibly following the instructions of your doctor or pharmacist. Do not flush medication down the toilet or sink.

Side Effects

Common Side Effects

All medications come with a risk of side effects. It is important to recognize that your doctor will have determined that the risk of side effects is outweighed by the potential benefit of this medication. Side effects are felt differently by everyone, and it is possible you will not experience any. Common side effects with Synthroid are:

  • Hair loss (temporary)
  • Menstrual irregularities
  • Diarrhea
  • Unintentional weight loss
  • Muscle weakness
  • Nervousness
  • Vomiting
  • Sweating

Severe Side Effects

On rare occasions, Synthroid can be associated with severe side effects that should be taken seriously. These include, but are not limited to:

  • Increased sweating
  • Heat sensitivity
  • Mood swings
  • Fatigue
  • Tremor
  • Headache
  • Shortness of breath
  • Bone pain
  • Bone loss or fractures, especially with long-term over-replacement

Seek emergency medical help if you experience any of the following:

  • Chest pain
  • Pounding/irregular heartbeat
  • Swollen hands, feet, or ankles
  • Seizures
  • Symptoms of an allergic reaction: rash, itching, facial swelling, difficulty breathing, severe dizziness

This is not an exhaustive list of side effects. If you experience anything unusual that causes concern, your symptoms worsen, or do not resolve on their own, contact your healthcare provider right away.

Warnings & Precautions

Allergies

Ensure your doctor is aware of any allergies you have, particularly if you are allergic to the active ingredient levothyroxine or any of the other ingredients of Synthroid. Tell your doctor if you have had a severe allergic reaction to anything in the past, and the symptoms you experienced.

Medical History

Prior to starting Synthroid, make sure your doctor knows your medical history, particularly if you have a history of increased thyroid hormones (thyrotoxicosis), reduced adrenal gland function, heart disease, hypertension, and diabetes.

Diabetes

Synthroid can affect your blood sugar. While you are taking Synthroid, ensure you check your blood sugar regularly and communicate with your doctor. If you have symptoms such as excessive thirst and/or urination, shakiness, abnormal sweating, dizziness, or hunger, your doctor will likely need to change your medication, exercise, or dietary schedule.

Surgery

Always let your doctor know what medications (prescription and non-prescription) you take regularly prior to having surgery.

Pediatric Use

Children may have a higher sensitivity to side effects such as headaches, vision changes, and lower limb pain. High thyroid hormone levels in children can stunt bone growth and development, so it is important to keep in regular contact with your doctor to monitor the treatment progress.

Geriatric Use

There is evidence to suggest that older adults and the elderly can have a higher sensitivity to side effects such as pounding/irregular heartbeat. This should be monitored while you are taking this medication.

Pregnancy

Studies have shown that Synthroid can be taken while pregnant. Consult your doctor first as your dose or other factors may need to be adjusted.

Breastfeeding

It has been shown that levothyroxine can pass into breast milk, however, it is unlikely to pose any risk to the infant. Check with your doctor if you are concerned.

Synthroid should only be used to treat the condition for which it is prescribed. Do not take Synthroid for any other purpose. Do not share this medication with anyone, even if they have the same condition as you. Do not take expired medication. Do not stop taking Synthroid or change the dosage unless your doctor tells you to. Do not mix brands of the active ingredient levothyroxine without consulting your doctor first.

Interactions & Contraindications

Medications that are taken at the same time can sometimes interact with one another, changing how they work or increasing the risk of side effects. Ensure your doctor is aware of all medications you regularly take, including non-prescription medications. Do not change the dosage, stop, or start taking any medication without consulting your doctor first.

Some medications can change the way thyroid hormone is absorbed by the body and should therefore not be taken within four hours of taking Synthroid. These include cholestyramine, colestipol, colesevelam, antacids, blood thinners, digoxin, sucroferric oxyhydroxide, iron, calcium supplements, phosphate bingers, glucocorticoids, statins, asthma medication, cold medicine, some antibiotics, some forms of cancer treatment, weight loss medication, epilepsy medication, painkillers such as ibuprofen or paracetamol, and hormone replacement therapy (estrogen or testosterone).

Buy Synthroid: Price & Coupons

Managing thyroid conditions can be challenging, especially with the high costs of medications like Synthroid in the United States. However, through Pharma Giant, you can access affordable medication from a trusted Canadian pharmacy.

By obtaining a prescription from your doctor, you can buy Synthroid online securely and conveniently through Pharma Giant. This provides significant savings, making essential treatments more accessible.

Pharma Giant collaborates with licensed Canadian pharmacies to ensure your prescriptions are fulfilled promptly and meet high standards of quality and safety. The process is efficient, and medications are express shipped to the United States within 3-5 business days, minimizing any disruption to your treatment plan.

To further reduce costs, we offer a special discount for first-time customers. Use the coupon code PGSAVE10 to save an additional 10% on your first order.

Synthroid Pricing

Strength Quantity PG Price
0.025mg 90 tabs $33.00
180 tabs $56.00
270 tabs $75.00
0.05mg 90 tabs $35.00
180 tabs $60.00
270 tabs $81.00
0.075mg 90 tabs $37.00
180 tabs $64.00
270 tabs $87.00
0.088mg 90 tabs $49.00
180 tabs $90.00
270 tabs $126.00
0.1mg 90 tabs $51.00
180 tabs $94.00
270 tabs $135.00
0.112mg 90 tabs $65.00
180 tabs $126.00
270 tabs $180.00
0.125mg 90 tabs $65.00
180 tabs $126.00
270 tabs $180.00
0.15mg 90 tabs $66.00
180 tabs $128.00
270 tabs $183.00
0.175mg 90 tabs $67.00
180 tabs $130.00
270 tabs $189.00
0.2mg 90 tabs $68.00
180 tabs $132.00
270 tabs $192.00
0.3mg 90 tabs $69.00
180 tabs $134.00
270 tabs $192.00
137mcg 90 tabs $99.00
180 tabs $190.00
270 tabs $270.00

Buy Synthroid through Pharma Giant allows U.S. patients to save significantly on their medication costs while benefiting from the reliable service of a trusted Canadian pharmacy.

Frequently Asked Questions

Thyroid supplements are typically taken for life. Keep taking Synthroid for as long as your doctor tells you to. It works to control your condition, but it is not a cure.

If you miss a dose, take it as soon as you remember. If you remember close to the time to take your next scheduled dose, skip the missed dose altogether. Take your next dose as scheduled. Do not take both to catch up unless your doctor instructs you to do so. If you miss two or more doses in a row, contact your doctor.

If you suspect an overdose, contact your doctor immediately or go to the closest hospital. Take your tablets with you, and tell the staff how much you took.

People who have overactive thyroid glands (thyrotoxicosis) should not take Synthroid. It is also not advised for people with untreated adrenal gland under-activity, a history of cardiac events, pregnant people taking anti-thyroid agents, or people with an allergy to any of the ingredients.

Synthroid is absorbed better on an empty stomach.

By stopping Synthroid suddenly, you risk worsening your condition and developing unwanted side effects. If you wish to come off Synthroid, your doctor will likely gradually decrease your dose before stopping it completely.

Yes, Synthroid can interact with other medications. Many drugs can affect how Synthroid is absorbed, metabolized, or used by the body. Medications like phosphate binders, bile acid sequestrants, proton pump inhibitors, antacids, and certain antidiabetic agents are known to interfere with Synthroid absorption.

Synthroid is primarily absorbed in the small intestine, particularly in the duodenum, jejunum, and ileum. When taken orally, it is absorbed from the upper part of the small intestine, with a relative bioavailability of approximately 93% compared to an equal dose of oral solution.

Synthroid and its generic versions are the same. Generic levothyroxine is a replica of Synthroid, with the same active ingredient in the same amount. Both work equally well for treating hypothyroidism. Generics are usually cheaper than brand-name medications.

Yes, Unithroid and Synthroid are both brand names for the drug levothyroxine. They contain the same active ingredient, levothyroxine, but their inactive ingredients may differ.

For adults with hypothyroidism, the typical starting dose of Synthroid is 1.6 mcg/kg of body weight once daily. It’s important to stick to the prescribed dose to avoid severe side effects such as confusion, seizures, and coma. Overdosing on Synthroid can be deadly. Mixing Synthroid with weight management medications can result in severe or life-threatening side effects.

Synthroid usually begins to exhibit its effects within 6 to 12  weeks.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

Have a prescription?

Order Synthroid online today and enjoy a host of benefits, including:

 Customer Reviews
  • Cost Savings: Buy Synthroid at LOWER PRICES compared to the US
  • Bulk Order Discounts: Enjoy additional savings with bulk orders of Synthroid (up to 90-day supply)
  • Reliable Express Shipping: Fast and discreet delivery shipped directly to your doorstep
  • Exceptional Customer Service: Have a question? We’re delighted to help via live chat, email, or phone
  • Easy & Secure Ordering: Seamless online or phone ordering at 1-888-513-2294
  • SAVE 10% on first order with coupon code: PGSAVE10

Price Match Guarantee

Price Match Guarantee

We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

Eligibility Criteria

  • The pharmacy must be a licensed Canadian online pharmacy with a verifiable address.
  • The competitor’s price must be current and active (not from a past or future promotion).
  • The product must be identical in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be submitted before placing an order — adjustments cannot be made after purchase.
  • Price matching does not apply to used or expired products.
  • Requests can be submitted via live chat or phone prior to completing your order.

Note: Price matching does not currently apply to Mounjaro® , Ozempic® or Saxenda®. However, this policy may be updated in the future.
Kenneth Fill, PharmD, MBA Fill

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.