Tecentriq (atezolizumab)

What is Tecentriq?

Tecentriq (atezolizumab) is a treatment that helps the body’s immune system fight certain types of cancer. It is used for lung cancer, liver cancer, skin cancer, and a rare type of soft tissue cancer.

Doctors may prescribe Tecentriq for adults with non-small cell lung cancer (NSCLC) after surgery and chemotherapy to help prevent the cancer from coming back.

It can also be used as a first treatment for NSCLC that has spread, but only if the cancer has a high level of PD-L1 and does not have specific gene mutations. PD-L1 is a protein that prevents the immune system from recognizing cancer cells.

For small cell lung cancer (SCLC), Tecentriq is given with chemotherapy when the tumor is in an advanced stage.

In liver cancer, called hepatocellular carcinoma (HCC), Tecentriq is used with bevacizumab for cases where the cancer has spread or cannot be removed by surgery. Tecentriq is also an option for melanoma, a type of skin cancer, when combined with other treatments if the tumor has a specific gene mutation.

Tecentriq is approved for children and adults with alveolar soft part sarcoma (ASPS), a rare cancer that affects soft tissues and has spread or cannot be removed by surgery.

Tecentriq is administered as an infusion into a vein and may cause side effects, including tiredness, cough, nausea, and changes in liver function.

Patients need to discuss their health history with a doctor before starting Tecentriq, especially if they have immune system problems, have had an organ transplant, or are pregnant.

How Does Tecentriq Work?

Tecentriq helps the body’s immune system attack cancer cells. Some cancers hide from the immune system by using a protein called PD-L1. This protein stops immune cells, called T cells, from attacking the tumor.

Tecentriq blocks PD-L1, allowing the immune system to recognize and fight the cancer.

By stopping PD-L1 from working, Tecentriq helps T cells stay active and attack tumors more effectively. This can slow down or even shrink the cancer. Tecentriq does not attack cancer directly; instead, it boosts the immune system’s ability to fight cancer on its own.

This makes it different from chemotherapy, which kills both cancer and healthy cells.

Dosage Form and Usage

Tecentriq is administered intravenously by healthcare providers. The Tecentriq dosage depends on the patient’s condition.

It is usually given every 2, 3, or 4 weeks.

A healthcare provider will determine the appropriate Tecentriq dosing schedule and monitor for side effects.

Dosage Form and Strengths of Tecentriq

Tecentriq is available in the following strengths:

• 840 mg/14 mL (60 mg/mL) solution in a single-dose vial
• 1200 mg/20 mL (60 mg/mL) solution in a single-dose vial

Tecentriq Administration

A healthcare provider administers Tecentriq through an intravenous IV infusion. The steps include:

1. 1. The healthcare provider checks the vial for discoloration or particles.
   2. The required dose is drawn and diluted with a 0.9% sodium chloride solution.

• Infusion:

1. • First infusion: Given over 60 minutes.
   • If tolerated: Subsequent infusions may be given over 30 minutes.
2. Blood tests may be done to check for side effects.
3. Tecentriq dosing continues until disease progression or unacceptable side effects occur.

Do not administer Tecentriq as an intravenous (IV) push or bolus, which involves rapidly injecting medication directly into a vein. Avoid mixing it with other medications in the same IV line.

Side Effects

Tecentriq can cause both common and severe side effects. Many people may feel tired, experience nausea, or lose their appetite. In some cases, serious reactions like severe cough, chest pain, or jaundice (yellowing of the skin and eyes) may occur.

Knowing the possible Tecentriq side effects is important, and speak with your doctor if you notice any unusual symptoms.

Common Side Effects

• Feeling tired or weak
• Decreased appetite
• Nausea
• Cough
• Shortness of breath
• Hair loss
• Constipation
• Diarrhea
• High blood pressure
• Skin rash
• Joint, muscle, or bone pain
• Fever
• Itching
• Swelling in legs or arms
• Mouth swelling
• Low thyroid hormone levels
• Sunburn or sun sensitivity

Severe Side Effects

• Changes in mood or behavior
• Dizziness
• Headache
• Excessive sweating
• Black or tarry stool
• Severe belly pain
• Blood in urine
• Producing less urine than normal
• Swelling in ankles
• Jaundice (yellowing of skin or eyes)
• Dark-colored urine
• Chest pain
• Severe cough
• Peeling or blistering skin
• Open sores in mouth, nose, or throat
• Swollen lymph nodes
• Severe infusion reactions
• Allergic reactions

Warnings and Precautions

Tecentriq can cause serious or life-threatening side effects that affect different organs in the body. Monitoring for symptoms, performing regular lab tests, and seeking medical care if side effects appear are important.

Patients may need to stop Tecentriq and take medications like corticosteroids to manage these reactions.

Below are the warnings and precautions for Tecentriq:

• Tecentriq can cause severe or fatal lung inflammation (pneumonitis), which can lead to coughing, breathing difficulties, and chest pain.
• It may cause colon inflammation (colitis), leading to diarrhea, stomach pain, or bloody stools.
• The medication can cause inflammation of the liver (hepatitis), which may result in the yellowing of the skin or eyes, dark urine, and unusual tiredness.
• Adrenal gland problems (adrenal insufficiency) can occur, causing fatigue, dizziness, nausea, and low blood pressure.
• It may lead to pituitary gland inflammation (hypophysitis), which can cause headaches, vision problems, and hormonal imbalances.
• Tecentriq can affect thyroid function, leading to either an overactive (hyperthyroidism) or underactive (hypothyroidism) thyroid, causing symptoms like weight changes, heart rate changes, or fatigue.
• It may cause inflammation of the pancreas (pancreatitis), which can lead to severe stomach pain, nausea, and vomiting.
• Severe skin reactions can occur, including rash, blisters, and peeling skin.
• It can lead to type 1 diabetes, which may cause frequent urination, extreme thirst, and high blood sugar levels.
• Tecentriq may cause kidney problems, leading to swelling, decreased urine output, and high blood pressure.
• Severe heart inflammation (myocarditis) can develop, resulting in chest pain, irregular heartbeat, and shortness of breath.
• Neurological problems, such as nerve inflammation (encephalitis or neuropathy), can lead to confusion, weakness, numbness, or difficulty walking.
• Tecentriq may lead to severe infusion-related reactions, which can cause fever, chills, low blood pressure, and difficulty breathing during or after administration.

Drug Interactions With Other Medications

Tecentriq and other treatments do not interact, meaning it has no known effects when taken with other medications.

However, to ensure safe and effective care, it is important to inform your doctor about all your treatments, including over-the-counter products, vitamins, and herbal supplements.

Alternative Medications

If you are considering alternatives to Tecentriq, it is important to know that several other treatments are available for similar conditions.

Each option works slightly differently, and your healthcare provider will help you determine which is best for your needs.

Here are some alternatives to Tecentriq:

• Opdivo (nivolumab)
• Keytruda (pembrolizumab)
• Tagrisso (osimertinib)
• Alimta (pemetrexed)
• Avastin (bevacizumab)
• Imfinzi (durvalumab)
• Yervoy (ipilimumab)
• Nivolumab
• Sylatron (pegylated interferon alfa-2b)
• Nexavar (sorafenib)
• Stivarga (regorafenib)

Save up to 90% on Tecentriq by Ordering Through Pharma Giant

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With Pharma Giant, you can order Tecentriq Canada at a fraction of the cost compared to local prices. We ensure you can access the medications you need without worrying about affordability.

Here is how Pharma Giant helps you save on Tecentriq cost:

• Pharma Giant offers the lowest possible prices on Tecentriq, working with licensed Canadian pharmacies to provide significant savings for up to 90% lower than typical prices.
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• Every prescription at Pharma Giant is filled by a U.S. doctor and verified by a Canadian pharmacist, ensuring the highest standards of safety and integrity.

Pharma Giant is committed to providing all patients affordable and reliable access to medications like Tecentriq. Let us handle the logistics so you can focus on your health.

How to Order Tecentriq Online from Canada?

1. To order Tecentriq, use the search bar at the top of the website to find the product. Select the desired strength and click “Buy” to add it to your cart. Continue adding any other medications if needed.
2. Once ready, proceed to checkout, enter your details, and log in or create an account. Use the coupon code PGSAVE10 for a 10% discount on your first order. After submitting, you will receive a confirmation email.
3. Upload or email your prescription to info@pharmagiant.com or fax it to 1-888-562-8159. If no prescription is needed, your order will be processed right away. Our team will contact you if we need anything else.

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Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.