What is Tiazac?
Tiazac is an extended-release diltiazem hydrochloride capsule used to help manage high blood pressure and chronic stable angina.
It belongs to a group of drugs called calcium channel blockers, which work by relaxing blood vessels and helping the heart pump with less strain.
Tiazac is taken by mouth and is available in several strengths for once-daily use.
For patients looking for Tiazac for hypertension, Tiazac for angina, or diltiazem extended-release capsules, this treatment is commonly prescribed when long-lasting blood pressure control or relief from chest pain symptoms is needed.
Because it is an extended-release form of diltiazem hydrochloride, it is designed to release the active ingredient gradually over time.
Indications and Benefits of Tiazac
Tiazac is indicated for the treatment of hypertension and chronic stable angina.
In people with high blood pressure, Tiazac helps relax the blood vessels, which lowers resistance and allows blood to move more easily through the body.
This can support better daily blood pressure control and may lower the strain placed on the heart and blood vessels over time.
In people with chronic stable angina, Tiazac helps the heart work more efficiently by reducing how much oxygen the heart muscle needs during activity. It can also help widen the coronary arteries, which improves blood flow to the heart.
As a result, Tiazac may help improve exercise tolerance, reduce angina episodes, and lower the need for fast-acting nitroglycerin in some patients.
Tiazac may be used alone or as part of a broader treatment plan with other blood pressure treatments, depending on the needs of the patient and the judgment of the prescribing provider.
What Are the Benefits of Tiazac?
- Tiazac helps lower high blood pressure by relaxing the blood vessels and reducing vascular resistance.
- Tiazac provides once-daily dosing through its extended-release formulation, which may support convenient long-term use.
- Tiazac may help reduce chest pain linked to chronic stable angina.
- Tiazac can improve exercise tolerance in some patients with ischemic heart disease.
- Tiazac may lower the number of angina attacks and reduce the need for nitroglycerin.
- Tiazac works throughout the day to provide steady support for blood pressure and heart workload.
- Tiazac may be used alone or with other antihypertensive treatments when clinically appropriate.
Fact Table
| Fact Category | Fact Details |
| Generic Name | Diltiazem hydrochloride |
| Tiazac Class | Calcium channel blocker |
| Primary Use | Used to treat high blood pressure and chronic stable angina |
| Additional Benefit | Helps lower the frequency and severity of chest pain and may reduce the risk of stroke, heart attack, and kidney problems linked to uncontrolled blood pressure |
| Available Form | Extended-release oral capsules, including 120 mg and 240 mg strengths |
| Method of Administration | Taken by mouth, usually swallowed whole. The capsule may also be opened and sprinkled on applesauce if advised, but the contents should not be chewed or crushed |
| Frequency | Usually taken once daily, or as directed by a healthcare provider |
| Storage Instructions | Store at room temperature away from heat, moisture, and direct light. Keep in a dry place and out of reach of children |
| Pregnancy and Breastfeeding | Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before using Tiazac. Use during pregnancy or breastfeeding should only be based on medical advice |
| Drug Interactions | May interact with beta-blockers, digoxin, other blood pressure treatments, and drugs that affect liver enzyme activity. Tell your healthcare provider about all prescription drugs, over-the-counter products, and supplements you use |
| Manufacturer | Bausch Health |
How It Works
Tiazac works by blocking the movement of calcium into the muscle cells of the heart and blood vessels.
This reduces resistance in the arteries, allowing blood to flow more easily and lowering blood pressure.
At the same time, Tiazac slows the heart rate slightly and reduces the force of contraction, which helps decrease how hard the heart has to work.
For patients using Tiazac for hypertension or Tiazac for angina, this combined effect supports steady blood pressure control. It helps reduce chest pain by improving blood flow and lowering the oxygen demand of the heart.
Dosage
The dosage of Tiazac is individualized based on the condition being treated and how the patient responds to therapy.
For both Tiazac for hypertension and Tiazac for angina, treatment usually starts at a lower dose and is gradually adjusted to achieve the desired effect.
Dose adjustments are typically made over time, often within 7 to 14 days, to allow the body to respond and to monitor blood pressure or symptom control.
Tiazac is taken once daily and is designed to release the active ingredient slowly throughout the day for consistent control.
Some patients may take Tiazac alone, while others may use it with additional cardiovascular treatments, depending on their condition.
What Dosage Strengths Does Tiazac Come In?
Tiazac extended-release capsules are available in multiple strengths to allow flexible dosing based on patient needs:
- 120 mg extended-release capsules
- 180 mg extended-release capsules
- 240 mg extended-release capsules
- 300 mg extended-release capsules
- 360 mg extended-release capsules
- 420 mg extended-release capsules
These strengths support gradual dose adjustments and long-term management of blood pressure and angina symptoms.
Tiazac Dosage Chart
| Condition | Starting Dose | Dose Adjustment | Typical Dose Range | Maximum Dose |
| Hypertension (High Blood Pressure) | 120 mg to 240 mg once daily | Adjust after about 14 days based on blood pressure response | 120 mg to 540 mg once daily | Up to 540 mg once daily |
| Chronic Stable Angina | 120 mg to 180 mg once daily | Increase gradually every 7 to 14 days based on symptom control | 120 mg to 540 mg once daily | Up to 540 mg once daily |
Dosing Reminders
- Take Tiazac extended-release capsules once daily at the same time each day.
- Follow the prescribed dose and do not adjust without medical guidance.
- Capsules should be swallowed whole or carefully opened and sprinkled on applesauce if needed.
- Do not chew or crush the capsule contents.
- Do not store any opened capsule mixture for later use.
- Dose may be adjusted when used with other blood pressure or heart treatments.
Usage Guide
Tiazac is taken by mouth and is designed for once-daily use to provide steady control of blood pressure and angina symptoms throughout the day.
For best results, it should be taken consistently at the same time each day.
Patients using Tiazac for hypertension or Tiazac for angina should follow the prescribed dose exactly and continue treatment even if they feel well, as high blood pressure may not always cause noticeable symptoms.
How do you take Tiazac?
- Take Tiazac once daily, or as directed by your doctor.
- Swallow the capsule whole with a glass of water.
- If needed, the capsule may be carefully opened and the contents sprinkled on a spoonful of applesauce.
- Swallow the applesauce mixture immediately without chewing.
- Do not crush, chew, or divide the capsule contents.
- Do not store any opened capsule mixture for later use.
- Take Tiazac at the same time each day to maintain consistent levels in the body.
- Continue taking Tiazac regularly, even if you feel well.
- Do not stop taking Tiazac suddenly without medical advice, as this may worsen your condition.
- Your healthcare provider may monitor your blood pressure and adjust your dose as needed.
Side Effects
Tiazac is generally well tolerated, and serious reactions are uncommon in clinical use. However, like all treatments, Tiazac may cause side effects in some patients. These effects can range from mild symptoms that improve over time to more serious reactions that require medical attention.
Common Side Effects
These side effects are more frequently reported and are usually mild to moderate:
- Headache
- Dizziness or lightheadedness
- Swelling of the ankles, feet, or hands
- Flushing or warmth of the skin
- Indigestion or stomach discomfort
- Fatigue or weakness
- Rash
- Sore throat or mild infection symptoms
- Diarrhea
- Palpitations
These symptoms may improve as the body adjusts to Tiazac. If they persist or become bothersome, medical advice should be sought.
Severe Side Effects
Although rare, some side effects can be serious and require immediate medical attention:
- Very slow heart rate or irregular heartbeat
- Fainting or severe dizziness
- Shortness of breath or difficulty breathing
- Signs of heart failure, such as sudden weight gain or swelling
- Severe skin reactions such as widespread rash, blistering, or peeling
- Signs of liver problems, such as dark urine, yellowing of the skin or eyes, or loss of appetite
- Severe allergic reactions, including swelling of the face, lips, tongue, or throat
Missed Dose
If you miss a dose of Tiazac, take it as soon as you remember. If it is close to your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
Do not take two doses at the same time to make up for a missed dose.
Taking Tiazac consistently each day is important for maintaining stable blood pressure and reducing angina symptoms.
Missing doses may affect how well Tiazac for hypertension or Tiazac for angina works, so try to take it at the same time daily.
Overdose
An overdose of Tiazac diltiazem extended-release can be serious and requires immediate medical attention.
Symptoms of overdose may include a very slow heart rate, low blood pressure, heart block, dizziness, fainting, or signs of heart failure.
In severe cases, complications can affect heart rhythm and circulation. Treatment usually involves supportive care such as monitoring heart function, stabilizing blood pressure, and managing symptoms in a medical setting.
If an overdose is suspected, seek emergency help right away. Early treatment is necessary to reduce the risk of serious complications from diltiazem overdose.
Storage Information
Store Tiazac capsules at room temperature, ideally at 25 degrees Celsius or 77 degrees Fahrenheit, with allowed variations between 15 to 30 degrees Celsius or 59 to 86 degrees Fahrenheit.
Keep the capsules in a dry place away from excessive heat, moisture, and direct light. Do not store in humid areas such as bathrooms. Proper storage helps maintain the effectiveness of Tiazac extended-release capsules.
Keep this product out of reach of children and store it in its original container until use.
Warnings
Tiazac should be used with caution in patients with certain heart and liver conditions.
Because Tiazac affects heart rate and blood vessel function, it may slow electrical signals in the heart and, in rare cases, lead to abnormal heart rhythms or conduction problems.
Patients with existing heart rhythm conditions, such as sick sinus syndrome or heart block, may be at higher risk.
Tiazac may also lower blood pressure, which can sometimes cause dizziness or fainting, especially when starting treatment or adjusting the dose.
In some cases, changes in liver enzyme levels have been reported, which may indicate stress on the liver. Patients using Tiazac for hypertension or Tiazac for angina should be monitored regularly to ensure safe and effective treatment.
- Tiazac may slow the heart rate and affect heart conduction, which can lead to bradycardia or heart block in some patients.
- Use caution in patients with congestive heart failure, especially those with reduced heart function, as symptoms may worsen.
- Tiazac may cause low blood pressure, which can result in dizziness, weakness, or fainting.
- Liver enzyme elevations may occur, particularly during the early weeks of treatment, and should be monitored when clinically appropriate.
- Combining Tiazac with beta-blockers or similar cardiovascular treatments may increase the risk of heart conduction issues.
- Careful dose adjustment and monitoring are recommended when starting or changing therapy.
- Patients should report any symptoms such as slow heartbeat, unusual fatigue, swelling, or yellowing of the skin or eyes. Proper monitoring helps ensure safe use of Tiazac extended-release capsules for blood pressure and angina management.
Contraindications
Tiazac should not be used in certain patients where it may pose serious health risks.
It is contraindicated in individuals with sick sinus syndrome or second- or third-degree atrioventricular block unless a functioning pacemaker is present, as it may further slow heart conduction.
It should also not be used in patients with severe low blood pressure, as this may worsen hypotension. Patients with a known hypersensitivity to diltiazem or any component of the formulation should avoid its use.
In addition, Tiazac is not recommended for patients with acute myocardial infarction accompanied by pulmonary congestion, as it may negatively affect heart function in this setting.
Careful evaluation is important before starting Tiazac for hypertension or Tiazac for angina to ensure it is appropriate for the patient.
Interactions
Tiazac may interact with several medications, especially those that affect the heart, blood pressure, or how drugs are processed in the body.
These interactions can increase side effects or change how well the treatment works.
When using Tiazac for hypertension or Tiazac for angina, it is important to review all medications with a healthcare provider.
Heart and Blood Pressure Interactions
- Beta-blockers such as propranolol may further slow the heart rate, which can lead to an unusually slow heartbeat
- Digitalis medications such as digoxin may affect the heart’s electrical signals, increasing the risk of irregular heart rhythm
- Other blood pressure treatments may enhance the blood pressure-lowering effect, which can cause dizziness or fainting
- Antiarrhythmic drugs, which are used to treat abnormal heart rhythm, may increase the risk of heart rhythm problems when combined
Liver Enzyme Interactions
Tiazac is processed in the liver by an enzyme system called CYP3A4, which helps break down drugs in the body.
- CYP3A4 inhibitors are drugs that slow down this enzyme, which can cause higher levels of Tiazac in the body and increase side effects
- CYP3A4 inducers are drugs that speed up this enzyme, which can lower Tiazac levels and reduce its effectiveness
- Other CYP3A4 substrates are drugs that use the same pathway, and their levels may increase or decrease when taken with Tiazac
Alternatives
Branded Alternatives
- Javadin
- Vostally
Generic Alternatives
Cost & Coupons
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Frequently Asked Questions
Buying Tiazac from Canada
FDA-Prescription, Off-Label Information, and Limitations
Dosage & Administration
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Food & Drug Interactions
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