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Trajenta Linagliptin
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What is Tradjenta?

Tradjenta (linagliptin) is an FDA-approved prescription medication used to help lower blood sugar in adults with type 2 diabetes.

Tradjenta is not suitable for people with type 1 diabetes and has not been tested in those with a history of pancreatitis, so it’s unclear if they face a higher risk of developing pancreatitis while using it. It’s also not recommended for children.

If you have allergies to Tradjenta or its ingredients, you should avoid taking it and seek medical help if you experience severe allergic reactions.

Always inform your healthcare provider of your medical history, including any past issues with pancreatitis, and discuss the use of Tradjenta if you are pregnant or breastfeeding.

How Does Tradjenta Work?

Tradjenta works by blocking a specific enzyme called DPP-4. This enzyme normally breaks down certain hormones in the body that help control blood sugar.

By inhibiting DPP-4, Tradjenta increases the levels of these hormones, which in turn helps the pancreas release more insulin when blood sugar is high and lowers the amount of glucose produced by the liver. This helps to keep blood sugar levels more stable.

Dosage Information and Usage

Tradjenta comes in the form of tablets. Each tablet is 5 mg, light red, round, and coated with a film. The tablet has “D5” on one side and the Boehringer Ingelheim symbol on the other.

Usage

The recommended dose of Tradjenta is one 5 mg tablet taken by mouth once a day, with or without food. It is important to follow your healthcare provider’s instructions carefully. If you miss a dose, take it as soon as you remember.

If it’s almost time for your next dose, skip the missed one and continue with your regular schedule.

Do not double up on doses. You can use Tradjenta with other diabetes medications, but be cautious as mixing it with certain drugs can raise the chance of low blood sugar.

Side Effects of Tradjenta

Common Side Effects

  • Stuffy or runny nose
  • Sore throat
  • Cough
  • Diarrhea

Serious but Rare Side Effects

  • Low blood sugar (hypoglycemia), especially if taken with other diabetes medicines like sulfonylureas or insulin. Symptoms include:
    • headache,
    • irritability,
    • drowsiness,
    • hunger,
    • weakness,
    • fast heartbeat,
    • dizziness,
    • sweating,
    • confusion, and
    • shaking
  • Serious allergic reactions
    • swelling of the face, lips, tongue, or throat,
    • hives,
    • difficulty swallowing or breathing, and
    • skin rash or itching.
  • Severe joint pain
  • Skin reactions like blisters or skin erosion (bullous pemphigoid) that may need hospital treatment
  • Heart failure, indicated by increasing shortness of breath, swelling in the feet or legs, rapid weight gain, or unusual tiredness

Warnings and Precautions

  • Pancreatitis: Acute pancreatitis, including fatal cases, has been reported in some patients using Tradjenta. Watch for signs of pancreatitis and stop the medication if suspected. It is unclear if those with a history of pancreatitis are at higher risk.
  • Hypoglycemia with Insulin and Insulin Secretagogues: Using Tradjenta with insulin or insulin secretagogues (like sulfonylureas) can increase the risk of low blood sugar. Adjusting the dose of these other medications might be necessary to avoid hypoglycemia, especially in those with severe kidney issues.
  • Hypersensitivity Reactions: Serious allergic reactions, including anaphylaxis and angioedema, have been reported. These reactions often occur within the first few months of starting Tradjenta. If an allergic reaction is suspected, stop taking Tradjenta and seek alternative treatments for diabetes.
  • Severe and Disabling Arthralgia: Some patients have experienced severe joint pain that can be disabling. Symptoms may start anytime after beginning the medication and may improve after stopping Tradjenta.
  • Bullous Pemphigoid: This skin condition, which causes blisters and skin erosion, has been reported in a small number of patients taking Tradjenta. If blisters or skin erosion develop, discontinue Tradjenta and consult a dermatologist for appropriate treatment.
  • Heart Failure: There is a possible link between Tradjenta and heart failure, especially in patients with a history of heart problems or kidney issues.

Overdosage

If you take too much Tradjenta, it’s important to get medical help right away. You should contact the Poison Help Line at 1-800-222-1222 or speak with a medical toxicologist for guidance on what to do.

Keep in mind that treatments like hemodialysis or peritoneal dialysis are not effective in removing Tradjenta from your body.

Drug Interactions

  • Inducers of P-glycoprotein or CYP3A4 Enzymes: Medications like rifampin can lower the levels of Tradjenta in the body, which may reduce its effectiveness. It’s best to avoid using Tradjenta with strong inducers of P-gp or CYP3A4 enzymes and consider alternative treatments.
  • Insulin Secretagogues or Insulin: Combining Tradjenta with insulin or insulin secretagogues (such as sulfonylureas) increases the risk of low blood sugar. When using Tradjenta with these medications, you may need to adjust the doses of insulin or insulin secretagogues to prevent hypoglycemia.

Alternative Medications

Here are the following alternative medications to Tradjenta:

Cost & Coupons

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At Pharma Giant, we are committed to providing top-quality medication with swift and reliable delivery right to your doorstep.

Our express shipping service guarantees your order will arrive within 3-5 business days anywhere in the US. Each shipment is packaged in secure containers to ensure your medication remains protected throughout its journey.

We pride ourselves on making essential treatments both accessible and affordable for everyone, regardless of insurance status.

Frequently Asked Questions

Tradjenta is a prescription medicine used to lower blood sugar in adults with type 2 diabetes. It is taken once daily and should be used alongside diet and exercise.

The most important information about Tradjenta is that it can cause serious side effects, including inflammation of the pancreas (pancreatitis), which can be severe and even fatal. Before starting Tradjenta, inform your healthcare provider if you have a history of pancreatitis, gallstones, alcoholism, or high blood triglyceride levels. If you experience severe, persistent abdominal pain that may radiate to your back, with or without vomiting, stop taking Tradjenta and contact your healthcare provider immediately, as this could be a sign of pancreatitis.

You should not take Tradjenta if you are allergic to linagliptin or any of its ingredients. Serious allergic reactions may include skin rash, itching, hives, and swelling of the face, lips, tongue, or throat, which can cause difficulty breathing or swallowing. If you experience any of these symptoms, stop taking Tradjenta immediately and contact your healthcare provider or go to the nearest emergency room.

Before starting Tradjenta, inform your healthcare provider about any history of pancreatitis, pregnancy, breastfeeding, or current medications. Share a comprehensive list of all drugs and supplements taken, as Tradjenta could interact with other medications.

Take Tradjenta exactly as your doctor directs. You should take one tablet once a day, with or without food. If you miss a dose, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and continue with your regular schedule—do not take two doses at once. If you take too much Tradjenta, contact your healthcare provider, or local poison control center, or go to the nearest emergency room immediately.

Tradjenta may cause serious side effects, such as low blood sugar (hypoglycemia), which can lead to symptoms like headache, dizziness, and sweating, especially if taken with insulin or other blood sugar-lowering medications. It can also cause severe allergic reactions, including swelling of the face, lips, tongue, or throat, and difficulty breathing. Some people may experience joint pain or a skin condition called bullous pemphigoid, which causes blisters or skin erosion. Additionally, Tradjenta might lead to heart failure, with symptoms like shortness of breath, swelling in the legs, and rapid weight gain.

Store Tradjenta at room temperature between 68°F and 77°F (20°C and 25°C). Keep it and all other medicines out of the reach of children.

The active ingredient in Tradjenta is linagliptin. The inactive ingredients include copovidone, corn starch, magnesium stearate, mannitol, and pregelatinized starch. The film coating contains hypromellose, polyethylene glycol, red ferric oxide, talc, and titanium dioxide.

If you stop taking Tradjenta, your blood sugar levels may not be as well controlled, which could lead to higher blood sugar levels. It’s important to talk with your doctor or pharmacist before stopping Tradjenta, as they can advise you on the best course of action and address any symptoms you may be experiencing. Do not stop taking Tradjenta unless your doctor recommends it.

A generic version of Tradjenta has been approved by the FDA. However, it may not be commercially available due to drug patents or exclusivity. The FDA has approved products equivalent to Tradjenta, but availability can vary.

You should take Tradjenta once daily at about the same time every day. You can take it with or without food. If you have trouble swallowing tablets, consult your doctor or pharmacist for advice.

Tradjenta remains in your body for varying lengths depending on the stage. The highest concentration (Cmax) is achieved roughly 1.5 hours post-intake. This medication has a therapeutic half-life of around 12 hours, with a terminal half-life of about 100 hours due to saturable binding.

No, Tradjenta should only be taken once a day, as directed by your doctor. Taking more than the recommended dose is not advised.

Tradjenta starts to work within a few days of starting treatment. However, it may take several weeks to reach its full effect. Your doctor will likely have you monitor your blood sugar levels to see how Tradjenta is affecting them.

The FDA, American Diabetes Association (ADA), and American Association of Clinical Endocrinology (AACE) advise against combining Tradjenta (a DPP-4 inhibitor) and Ozempic (a GLP-1 agonist). Using these medications together does not offer extra benefits and is typically avoided in treating type 2 diabetes.

Yes, Tradjenta can potentially cause pancreatitis, including severe cases. There have been reports of acute pancreatitis, and in some cases, it has been fatal. If you experience symptoms of pancreatitis, such as severe abdominal pain, you should stop taking Tradjenta and seek medical attention immediately.

Tradjenta comes in a single dose strength: 5 mg tablets.

Tradjenta 5 mg can be taken with or without food. It’s important to take it at the same time each day to maintain a steady level of the medication in your body.

Tradjenta is contraindicated in patients who have a history of hypersensitivity reactions to linagliptin, such as urticaria (hives), angioedema (swelling), or bronchial hyperreactivity (excessive airway reaction).

If you miss a dose of Tradjenta, take it as soon as you remember. If it’s almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not take two doses at the same time to make up for a missed dose.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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