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Treximet Sumatriptan Succinate, Naproxen Sodium
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What is Treximet?

Treximet (sumatriptan/naproxen) is a prescription medication used to treat migraine headaches in adults and children aged 12 years and older.

A migraine is more than a regular headache. It can cause intense pain and nausea and make you very sensitive to light and sound. Some people also see flashing lights or feel dizzy before the headache starts. These signs are called auras.

Treximet relieves migraine symptoms by combining two medications. One is sumatriptan, which helps calm down overactive nerves in the brain. The other is naproxen, a pain reliever that reduces swelling and discomfort.

Treximet is also available in a generic version, which has the same active ingredients and works the same way.

Both versions need a prescription. Treximet is not used to stop migraines from happening. It is only used when a migraine attack has already started.

How Does Treximet Work?

Treximet combines two active ingredients, sumatriptan and naproxen, to treat migraine headaches.

Sumatriptan narrows swollen blood vessels in the brain during a migraine and blocks pain signals sent by nerves in the head, reducing pain. Naproxen reduces swelling and calms inflamed areas. Together, these ingredients target migraine symptoms like head pain, nausea, and sensitivity to light or sound.

Treximet works within one to two hours after a dose. It reduces swollen blood vessels and pain signals, providing more complete relief. This combination works better than using either ingredient alone.

Treximet treats migraines when they start and stops them from worsening, but does not prevent future migraines.

Treximet Dosage and Administration

Treximet is a tablet that is taken by mouth. Your doctor will recommend a dosage based on your age, liver function, and overall health.

Treximet can be taken with or without food, but the tablets should always be swallowed whole with a glass of water.

Dosage Form and Strengths of Treximet

Treximet is available in two different tablet strengths:

  • 85 mg sumatriptan / 500 mg naproxen sodium
  • 10 mg sumatriptan / 60 mg naproxen sodium

How to Take Treximet?

Follow these steps when taking Treximet to treat migraine:

  1. Take Treximet only when you have a migraine.
  2. Swallow one whole tablet with water. Do not crush, chew, or split it.
  3. You can take it with or without food.
  4. If you feel some relief but your headache returns, wait at least 2 hours before taking another tablet.
  5. Do not take over two 85/500 mg tablets within 24 hours.
  6. If you get no relief from the first dose, talk to your doctor before taking a second dose.

Treximet Dosing for Different Groups

Adults (18 years and older)

Adults start with one Treximet tablet that contains 85 mg of sumatriptan and 500 mg of naproxen. If the migraine returns or does not improve, they take a second tablet at least two hours after the first. Do not take more than two tablets in 24 hours.

Children (12 to 17 years)

For children between 12 and 17 years old, the recommended dose is one tablet that contains 10 mg of sumatriptan and 60 mg of naproxen. They should not take more than one 85 mg/500 mg tablet in 24 hours. It is unknown if taking more than one dose daily is safe for this age group.

Patients with Liver Problems

People with severe liver problems should not use Treximet. Those with mild to moderate liver issues may take one tablet containing 10 mg of sumatriptan and 60 mg of naproxen in a 24-hour period. These patients need to follow their doctor’s instructions carefully.

Treximet Side Effects

Some Treximet side effects are mild and go away on their own, while others can be serious and may require medical attention.

Common side effects include dizziness, nausea, and dry mouth. Serious side effects may involve stomach pain, liver problems, high blood pressure, or even seizures. Knowing what to look out for and when to contact your doctor is important.

Common Side Effects

Some Treximet side effects are more common and may not need medical treatment unless they continue or get worse:

  • Dizziness
  • Nausea
  • Dry mouth
  • Feeling weak or tired
  • Drowsiness
  • Tingling or numbness in fingers or toes
  • Heartburn
  • Feeling hot or flushed
  • Pain or tightness in the neck, chest, throat, or jaw
  • Muscle stiffness
  • Irregular heartbeat

Severe Side Effects

Serious Treximet side effects can be dangerous. Call your doctor right away if you notice any of the following:

  • Sudden or severe stomach pain
  • Vomiting blood or having black, tarry stools
  • Yellowing of the skin or eyes
  • Swelling in arms, legs, hands, or feet
  • Trouble breathing or chest pain
  • High blood pressure that is new or getting worse
  • Fast heartbeat or trouble walking
  • Changes in mood, confusion, or seeing things that are not there
  • Seizures
  • Flu-like symptoms or unusual tiredness
  • Pain or cramping in the legs or hips
  • Cold or discolored feet or legs
  • Itching or rash
  • Nausea that is not related to your migraine
  • Bloody diarrhea or stomach pain after eating
  • Trouble with blood flow to the legs and feet
  • Signs of serotonin syndrome, such as fever, stiff muscles, and fast heartbeat

Warnings and Precautions for Treximet

Treximet can help relieve migraine pain, but it also comes with severe warnings and precautions. It may increase the risk of heart problems, stroke, stomach bleeding, and liver or kidney damage.

You should not take Treximet if you have certain health conditions or are in the late stages of pregnancy. Always talk to your doctor before starting this medication to ensure it is safe.

  • Treximet may raise the risk of heart attack and stroke, especially during long-term use or if you already have heart problems.
  • You should not take Treximet before or after coronary artery bypass surgery, as it can be dangerous.
  • This medication can cause stomach ulcers, bleeding, or holes in the stomach or intestines, which can happen without warning and may be life-threatening.
  • Older adults and people with a history of stomach bleeding or ulcers are more likely to have digestive side effects.
  • If you have heart failure, Treximet can worsen your condition and lead to serious health problems.
  • People with coronary artery disease or a history of heart attack should avoid Treximet unless advised otherwise by a doctor.
  • If you are at risk for stroke or have had a mini-stroke, Treximet may not be a safe choice for you.
  • Treximet can cause problems if you have an irregular heartbeat, so doctors should check your heart before you start this medication.
  • If you have uncontrolled high blood pressure, Treximet may make it worse and reduce the effect of your blood pressure medications.
  • Treximet harms the liver, so people with liver disease should avoid it or undergo close monitoring.
  • Kidney damage can increase the chance of serious side effects, so people with kidney problems should not use Treximet without a doctor’s advice.
  • You should not take Treximet if you are allergic to NSAIDs, aspirin, or its ingredients.
  • People with asthma who get worse with NSAIDs or aspirin should not use Treximet.
  • If you have blood flow problems, such as Raynaud’s disease or ischemic colitis, Treximet may not be safe for you.
  • Do not use Treximet in the last three months of pregnancy because it may harm the unborn baby.
  • It is unclear if Treximet is safe in early pregnancy, so talk to your doctor before using it.
  • Treximet may not be safe to use while breastfeeding, as its ingredients can pass into breast milk.
  • Drinking alcohol while using Treximet can raise the risk of stomach bleeding, so it should be avoided.
  • Taking too much Treximet can cause serious side effects such as stomach pain, vomiting, breathing trouble, muscle problems, or even death.
  • If you think you have taken too much Treximet, get emergency help or call a poison control center right away.

Treximet Drug Interactions

Treximet can interact with many different medications, which may change how Treximet or the other drugs work.

These interactions can also raise your risk of side effects, including serious ones like bleeding, kidney problems, or high serotonin levels.

Before starting Treximet, always tell your doctor or pharmacist about all the medications, vitamins, and supplements you use.

  • hydrochlorothiazide
  • furosemide
  • spironolactone
  • isocarboxazid
  • phenelzine
  • tranylcypromine
  • cyclosporine
  • ergotamine
  • dihydroergotamine
  • methylergonovine
  • warfarin
  • acetylsalicylic acid
  • fluoxetine
  • sertraline
  • citalopram
  • duloxetine
  • venlafaxine
  • desvenlafaxine
  • lisinopril
  • benazepril
  • enalapril
  • losartan
  • irbesartan
  • valsartan
  • propranolol
  • metoprolol
  • atenolol
  • digoxin
  • lithium
  • methotrexate
  • pemetrexed

Alternative Medications to Treximet

If you are looking for alternatives to Treximet, several medications can be used to treat migraines.

Consult your doctor to find the one that works best for you.

  • Axert (almotriptan)
  • Relpax (eletriptan)
  • Frova (frovatriptan)
  • Amerge (naratriptan)
  • Maxalt (rizatriptan)
  • Imitrex (sumatriptan)
  • Zomig (zolmitriptan)
  • DHE-45 injection, Migranal (dihydroergotamine)
  • Ergomar
  • Advil, Motrin (ibuprofen)
  • Aleve, Anaprox (naproxen)
  • Ansaid (flurbiprofen)
  • Cataflam, Cambia (diclofenac)
  • Indocin (indomethacin)
  • Excedrin Migraine (aspirin/acetaminophen/caffeine)
  • Duradrin (acetaminophen/isometheptene/dichloralphenazone)

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  3. You can send us your prescription by uploading it on the website, emailing it to info@pharmagiant.com, or faxing it to 1-888-562-8159.

Frequently Asked Questions

No, Treximet is not a narcotic. It contains sumatriptan and naproxen, which are not classified as narcotics.
Yes, the generic version of Treximet is Sumatriptan-Naproxen Sodium.
Treximet works by affecting certain receptors in the brain to reduce swelling in blood vessels, which helps relieve migraine pain. The sumatriptan in Treximet also prevents pain signals from traveling through the nervous system. Naproxen, a type of pain reliever, reduces inflammation and further helps with pain relief.
Treximet stays in your system for about 10 hours. The sumatriptan dose is usually cleared from the body during this time, and any minor side effects typically fade by then. However, some side effects may require temporarily stopping the medication, and recovery can take a few days.
The safety of taking Treximet more than five times in 30 days is unknown. It is important to follow your doctor’s guidance on how often to take it.
It is not recommended to drink alcohol while taking Treximet. Alcohol can increase the risk of stomach bleeding.
You can take Treximet up to 2 tablets in 24 hours, with at least 2 hours between doses.
Treximet can cause several side effects, including serotonin syndrome, allergic reactions, nausea, and rebound headaches. Some people may experience dizziness, seizures, trouble swallowing, or throat tightness. Other serious side effects can include cardiac arrest, heart arrhythmia, high blood pressure, kidney problems, and stomach bleeding. You might also notice abdominal pain, chest pain, or weakness. In some cases, liver problems, anemia, and a racing heart can occur.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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