What is Trifexis?
Trifexis (spinosad/milbemycin oxime) is a chewable tablet for dogs that helps protect them from five common parasites.
Trifexis is made for dogs and puppies that are at least 8 weeks old and weigh 5 pounds or more.
You give it once a month, and it keeps your dog safe from:
- Fleas: These small pests live on your dog’s skin and cause itching, skin infections, and discomfort.
- Heartworms: Spread by mosquitoes, these worms can be deadly if not prevented.
- Hookworms: These attach to your dog’s intestines and cause blood loss and diarrhea.
- Roundworms: These live in the gut and may cause weight loss, poor growth, and digestive upset.
- Whipworms: These parasites live in the large intestine and can cause symptoms such as bloody stool and weakness.
How Does Trifexis Work?
Trifexis combines two ingredients: spinosad and milbemycin oxime. These ingredients kill fleas, prevent heartworm disease, and treat common intestinal worms like hookworms, roundworms, and whipworms.
Spinosad is a medication that kills fleas. After your dog takes the tablet, this ingredient enters the bloodstream.
When fleas bite your dog, they swallow the spinosad, which then affects their nervous system and causes them to die. It works fast and keeps protecting your dog from fleas for a whole month.
Milbemycin oxime is a treatment that prevents heartworms and kills certain intestinal worms. Heartworms are dangerous parasites spread by mosquito bites.
They grow inside your dog’s heart and lungs and can cause serious illness or even death.
Milbemycin oxime also protects against worms that live in the intestines, like hookworms, which suck your dog’s blood, roundworms, which feed on food in the gut, and whipworms, which cause bloody diarrhea and other stomach problems.
Trifexis Dosage and Administration
Selecting the correct Trifexis dosage helps protect your dog from harmful parasites such as fleas, heartworms, and intestinal worms.
This monthly chewable tablet is available in different strengths to match your dog’s weight.
Dosage Form and Strengths of Trifexis
Trifexis is available in five tablet sizes. Each is flavored and color-coded based on weight ranges:
- 140 mg spinosad / 2.3 mg milbemycin oxime
- 270 mg spinosad / 4.5 mg milbemycin oxime
- 560 mg spinosad / 9.3 mg milbemycin oxime
- 810 mg spinosad / 13.5 mg milbemycin oxime
- 1,620 mg spinosad / 27 mg milbemycin oxime
Trifexis Dosage Chart
| Dog Weight (lbs) | Spinosad per tablet (mg) | Milbemycin oxime per tablet (mg) | Tablets to give |
| 5 – 10 | 140 | 2.3 | 1 |
| 10.1 – 20 | 270 | 4.5 | 1 |
| 20.1 – 40 | 560 | 9.3 | 1 |
| 40.1 – 60 | 810 | 13.5 | 1 |
| 60.1 – 120 | 1620 | 27 | 1 |
| Over 120 | Use the right combo of tablets | Use the right combo of tablets | Based on weight |
How to Take Trifexis?
- Give Trifexis by mouth once a month
- Give food to help your dog absorb the medication better
- Watch your dog for an hour after dosing to make sure it does not vomit
- If your dog vomits within one hour, give another full dose
- If you miss a dose, give it as soon as you remember, then go back to the regular monthly schedule
Trifexis Overdose
A Trifexis overdose can happen if your dog eats too many tablets. Signs may include vomiting, drooling, shaking, or reduced appetite. In severe cases, it could cause tremors or seizures. If you think your dog has had an overdose, call your vet right away.
Side Effects of Trifexis
Some dogs may experience side effects from a Trifexis prescription, although most reactions are mild. The most common side effects of Trifexis include vomiting, itching, tiredness, and diarrhea.
More serious effects like seizures, muscle tremors, and disorientation can occur, especially if the dog is also taking other treatments not prescribed for use with Trifexis.
Common Side Effects
These mild side effects were seen in more than 1 out of 100 dogs during clinical studies:
- Vomiting
- Itching or scratching
- Tiredness or low energy
- Diarrhea
- Skin redness or rash
- Decreased appetite
- Redness of the ears
- Mild skin irritation
Severe Side Effects
These rare but serious side effects may occur, especially when Trifexis is used with other treatments like high doses of ivermectin:
- Muscle shaking or twitching
- Drooling or salivation
- Seizures
- Trouble walking or balance issues (ataxia)
- Enlarged pupils or vision changes
- Disorientation or confusion
- Sudden changes in behavior
Warnings and Precautions for Trifexis
Trifexis helps protect dogs from parasites, but it is not right for every situation. Some dogs may experience side effects, especially if they already have underlying health issues such as epilepsy or heartworm infection.
- Keep Trifexis away from children and do not give this medication to humans.
- Do not use Trifexis with high doses of ivermectin, as it may cause serious side effects like shaking, drooling, or seizures.
- Administer at least three monthly doses after the last mosquito season to ensure your dog remains protected from heartworm.
- Test your dog for heartworm before starting Trifexis. If your dog already has heartworm, your vet may need to treat it first with a different product.
- Trifexis does not kill adult heartworms and is not used to clear microfilariae, which are baby heartworms in the blood.
- Some dogs with a high number of microfilariae (baby heartworms that live in a dog’s bloodstream) may exhibit mild reactions, such as trouble breathing, vomiting, drooling, or fatigue.
- Use Trifexis carefully in female dogs that are used for breeding.
- The safety of Trifexis in breeding male dogs has not been fully studied.
- Use Trifexis with caution in dogs that have epilepsy, as it may increase the risk of seizures.
- Puppies younger than 14 weeks old may vomit more often when given Trifexis.
Alternatives to Trifexis
If your dog does not respond well to a Trifexis prescription or you want to try other options, there are several safe and effective choices for flea and heartworm prevention.
Some products target both parasites, while others focus on one. When choosing an alternative, consider your dog’s age, weight, health history, and the method of administration, whether it is given orally or applied to the skin.
Consult your vet before switching preventatives.
- Sentinel
- NexGard Spectra
- Heartgard Plus
- Simparica Trio
- Revolution Plus
- Advantage Multi
- Bravecto Plus
- Interceptor Plus
Order Trifexis online from Canada
Protecting your dog from fleas, heartworms, and intestinal worms should not be a difficult or expensive undertaking.
Purchasing Trifexis from Canada allows you to control the costs of ongoing parasite protection without jeopardizing your dog’s health.
Pharma Giant offers a simple, secure, and economical option to purchase Trifexis online. Our platform connects you with approved Canadian pharmacies and delivers your dog’s Trifexis medication to your home in a matter of days.
You can even apply a Trifexis coupon to save even more money and receive up to a three-month supply for a lower overall Trifexis cost.
Why order Trifexis from Canada through Pharma Giant?
- Quality Trifexis from Canada, verified by licensed Canadian pharmacists.
- We offer competitive Trifexis prices with no hidden fees.
- Use a Trifexis coupon or take advantage of bulk order discounts.
- Enjoy fast and secure delivery across the U.S. in just 3 to 5 business days.
- We pack your order with care, including temperature control when needed.
- Our customer support team is always ready to help.
How to Order Trifexis Online?
- Find Trifexis on the Pharma Giant, choose the right strength for your dog, and click Buy.
- At checkout, enter your name, shipping address, and payment details. Use code PGSAVE10 to get 10% off your first order.
- Send your prescription by uploading it, emailing info@pharmagiant.com, or faxing it to 1-888-562-8159.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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