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Triumeq
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Triumeq Abacavir (Abacavir Sulfate), Dolutegravir, Lamivudine
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What is Triumeq?

Triumeq is a prescription medication used to treat HIV-1 infection in adults and children weighing at least 55 pounds (25 kg).

It contains three ingredients: abacavir, dolutegravir, and lamivudine. These work together to help control the HIV-1 virus, which causes Acquired immunodeficiency syndrome (AIDS).

Triumeq should not be taken by individuals with certain genetic variations, allergies to its ingredients, severe liver problems, or those taking dofetilide, pilsicainide, or fampridin, as these conditions can lead to serious or life-threatening side effects.

Always inform your healthcare provider about your medical history and any other medicines you are taking before starting Triumeq.

How Does Triumeq Work?

Triumeq works by combining three medicines that fight HIV-1 infection in different ways. One of its ingredients, dolutegravir, is an integrase inhibitor. It stops an enzyme called integrase, which the virus needs to make more copies of itself.

The other two ingredients, abacavir and lamivudine, are called nucleoside analog reverse transcriptase inhibitors.

They prevent the virus from making DNA, which it needs to reproduce. By using these three medicines together, Triumeq helps to control the HIV-1 virus in the body.

Dosage Information and Usage

Dosage Form and Strengths of Triumeq

  • Triumeq tablets are purple, biconvex, oval, and debossed with “572 TRI” on one side.
  • Each film-coated tablet contains:
    • 600 mg of abacavir (as abacavir sulfate)
    • 50 mg of dolutegravir (as dolutegravir sodium)
    • 300 mg of lamivudine

Usage

Triumeq is used to treat HIV-1 infection in adults and children weighing at least 55 pounds (25 kg).

It should be taken exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Triumeq without consulting your healthcare provider.

It is important to stay under medical care while on Triumeq. You can take Triumeq with or without food. If you miss a dose, take it as soon as you remember, unless it is within 4 hours of your next dose, in which case you should skip the missed dose and continue with your regular schedule.

Do not take two doses at the same time. Make sure you do not run out of Triumeq to prevent the virus from becoming resistant. If you take too much, contact your healthcare provider or go to the nearest emergency room immediately.

Storage Information

Store Triumeq tablets in their original bottle with a child-resistant cap, and keep the bottle tightly closed to protect the tablets from moisture.

Do not remove the desiccant inside the bottle. Keep the tablets at room temperature, ideally at 25°C (77°F), but they can be stored within a range of 15° to 30°C (59° to 86°F).

Always ensure the bottle is kept in a dry place to maintain the effectiveness of the medication.

Side Effects

Common Side Effects

  • Trouble sleeping
  • Headache
  • Tiredness

Serious but Rare Side Effects

  • Severe allergic reactions:
    • Fever,
    • Rash,
    • Nausea,
    • Vomiting,
    • Diarrhea,
    • Stomach pain,
    • Extreme tiredness,
    • Body aches,
    • Trouble breathing,
    • Sore throat,
    • Cough
  • Serious liver problems:
    • Nausea,
    • Vomiting,
    • Loss of appetite,
    • Pain in the right side of the stomach,
    • Yellowing of the whites of the eyes or skin,
    • Dark-colored urine,
    • Light-colored stool
  • Too much lactic acid in the blood
    • Weakness,
    • Tiredness,
    • Nausea,
    • Fast heartbeat,
    • Muscle pain, arms, and legs feeling cold
  • Changes in liver tests, especially in people with hepatitis B or C
  • Immune Reconstitution Syndrome, where the immune system starts fighting hidden infections
  • Changes in body fat distribution, like increased fat in the upper back, neck, breasts, and around the middle of the body, and loss of fat from the legs, arms, and face
  • Increased risk of heart attack (myocardial infarction)

Warnings and Precautions

  • Hypersensitivity Reaction: Serious and sometimes fatal allergic reactions can occur with abacavir or dolutegravir; patients with the HLA-B*5701 gene are at higher risk and should not take Triumeq if they have this gene. HLA-B5701 is a gene variation that can cause severe allergic reactions to the HIV medicine abacavir. Stop using Triumeq immediately if any signs of hypersensitivity appear.
  • Lactic Acidosis and Severe Liver Enlargement: Rare but serious conditions involving too much lactic acid in the blood and enlarged liver with fat buildup can occur; stop using Triumeq if symptoms or lab results suggest these conditions.
  • Patients with Hepatitis B or C: Patients with hepatitis B or C may have an increased risk of liver problems when using Triumeq; monitor liver function before and during treatment, and watch for signs of hepatitis worsening after stopping Triumeq.
  • Use with Interferon and Ribavirin: Patients on Triumeq with Interferon and Ribavirin need close monitoring for treatment-related side effects, particularly liver issues. Interferons are natural substances made by white blood cells and other body cells, aiding the immune system in battling infections and diseases such as cancer. Ribavirin is an antiviral medication combined with others to treat hepatitis C, a viral infection leading to persistent liver inflammation.
  • Immune Reconstitution Syndrome: When starting Triumeq, the immune system may become stronger and start fighting hidden infections, which can cause inflammation; monitor for new symptoms and treat as necessary.
  • Fat Redistribution: Changes in body fat distribution may occur, such as increased fat in the upper back, neck, breasts, and trunk, and loss of fat in the legs, arms, and face.
  • Myocardial Infarction (Heart Attack): Some studies suggest a potential increased risk of heart attack with abacavir use; consider underlying heart disease risk factors when prescribing Triumeq.

Overdosage of Triumeq

If someone overdoses on Triumeq, there is no specific treatment available. Monitoring the person closely and providing standard supportive care is essential.

Dolutegravir binds tightly to blood proteins, making it unlikely to be removed significantly by dialysis. It’s unclear if abacavir can be removed by dialysis.

Lamivudine is minimally removed by short-term dialysis methods, so continuous hemodialysis may not be beneficial in an overdose.

Monitoring and supportive care are key strategies in case of an overdose.

Drug Interactions

  • Dolutegravir can increase blood levels of dofetilide, dalfampridine, and metformin by affecting kidney transporters, so dose adjustments may be needed to avoid toxicity.
  • Drugs that boost enzymes like UGT1A1 and CYP3A can lower dolutegravir levels, reducing its effectiveness against HIV. UGT1A1 enzymes help attach glucuronic acid to substances in the body. CYP3A enzymes break down drugs and other substances.
  • Etravirine and Efavirenz reduce dolutegravir levels, so it’s important to adjust the dose or avoid using them with Triumeq to maintain effectiveness.

Alternative Medications

Here are some of the alternatives to Triumeq:

  • Atripla
  • Bictegravir / emtricitabine / tenofovir alafenamide
  • Cabenuva
  • Dovato
  • Genvoya
  • Isentress
  • Norvir
  • Stribild
  • Tivicay
  • Truvada

Price & Coupons

At Pharma Giant, we believe managing your health should be affordable and accessible. As healthcare costs continue to challenge many Americans, we are dedicated to offering high-quality medications at lower prices.

Here are our unbeatable Triumeq options:

Strength Quantity Price
600mg/50mg/300mg 30 tablets $2,499
600mg/50mg/300mg 60 tablets $4,798
600mg/50mg/300mg 90 tablets $6,897

Pharma Giant is committed to easing the financial burden of healthcare. Choose us for cost-effective medication solutions to support your health and well-being without breaking the bank.

Note: Triumeq can cost over $3,800 in the United States.

Discount Code and Offer

Maximize your savings on essential medication with Pharma Giant’s exclusive discount offer.

Apply the code PGSAVE10 at checkout to enjoy a 10% reduction on your purchase of Triumeq.

This limited-time deal ensures you receive top-quality healthcare products at an unbeatable price. Don’t wait—this special promotion is valid for one-time use per customer.

Commitment to Quality and Swift Delivery

At Pharma Giant, we are dedicated to providing high-quality medications and ensuring they reach you swiftly and securely.

With our expedited shipping, you can anticipate delivery within 3-5 business days throughout the United States.

We take extra precautions by packaging with cooling packs to guarantee the integrity of your medication during transit.

Our mission is to make essential treatments both accessible and affordable for everyone, regardless of insurance coverage.

Frequently Asked Questions

Triumeq is a medication used to treat HIV-1 infection in adults and children aged at least 6 years old. It combines three different drugs—abacavir, dolutegravir, and lamivudine—in a single tablet to help control the virus and improve immune function.

Before using Triumeq, here are some important things to know:
  • Allergies: Do not use Triumeq if you are allergic to abacavir, dolutegravir, lamivudine, or any ingredients in these medications.
  • Other Medications: Avoid Triumeq if you are taking dofetilide, pilsicainide, or fampridine.
  • Liver Disease: If you have serious liver disease, Triumeq may not be suitable for you.
  • Kidney Problems: Inform your doctor if you have kidney issues as you may need extra checkups while taking Triumeq.
  • Other Conditions: Discuss any other medical conditions you have with your doctor before starting Triumeq.
  • Allergies and Medications: Inform your doctor about any allergies to medicines, foods, preservatives, or dyes.
  • Side Effects: Be aware of possible side effects during treatment and understand how to monitor for them.

While using Triumeq, here’s what you should know:
  • Inform Healthcare Providers: Tell your doctor, dentist, and pharmacist that you are taking Triumeq before starting any new medicine or undergoing surgery.
  • Attend Appointments: Attend all scheduled doctor appointments to monitor your health and treatment progress.
  • Pregnancy: Contact your doctor immediately if you become pregnant while on Triumeq.
  • Hypersensitivity Reaction: Triumeq contains abacavir, which can cause a severe allergic reaction. Symptoms may include fever, skin rash, nausea, vomiting, or difficulty breathing. Seek medical attention if you experience these symptoms.
  • Regular Blood Tests: Expect regular blood tests to monitor for potential side effects.
  • Driving and Machines: Be cautious when driving or operating machinery as Triumeq may cause dizziness or affect your alertness.
  • Storage: Store Triumeq in its original packaging away from moisture and heat, and out of reach of children. Do not keep it in the bathroom.
  • Disposal: Dispose of unused or expired Triumeq at a pharmacy for proper disposal.

Yes, there are potential side effects of using Triumeq. The most common ones include fever, skin rash, nausea, vomiting, stomach pain, tiredness, headache, and rash. Additionally, Triumeq contains abacavir, which can cause a serious allergic reaction called hypersensitivity. This reaction can be life-threatening if Triumeq is continued after symptoms like skin rash or combinations of symptoms such as fever, shortness of breath, nausea, or severe tiredness occur.

If you’re taking other medicines alongside Triumeq, it’s important to inform your doctor or pharmacist. Some medicines may interact with Triumeq and affect its effectiveness. Specifically:
  • Do not take Triumeq with dofetilide, pilsicainide (for heart conditions), or fampridine (for multiple sclerosis).
  • Avoid using Triumeq with emtricitabine or sorbitol-containing medicines.
  • Inform your doctor if you’re taking metformin, antacids (except those containing aluminum, calcium, or magnesium), calcium or iron supplements (taken separately from Triumeq), or medications for HIV, tuberculosis, epilepsy, bipolar disorder, or depression.
  • If you take methadone, your doctor may need to adjust your dose, as Triumeq can affect how methadone is processed in your body.

Triumeq doesn’t directly lead to high blood pressure, but it could raise your heart attack risk. If you have heart issues, smoke, high blood pressure, or diabetes, discuss with your doctor how Triumeq may impact you, how your condition might affect the drug’s effectiveness, and if special monitoring is necessary.

Crushing Triumeq tablets isn’t advised unless there are medical reasons like swallowing issues. Crushing could change how the medication works and impact its effectiveness. If crushing is necessary, do it under medical supervision for proper administration and effectiveness.

To use Triumeq, swallow the tablets whole with water. No need to take them with food.

  • Triumeq contains abacavir, which can cause serious allergic reactions. Do not take it if you’ve had an allergic reaction to abacavir before.
  • Inform your doctor about kidney or liver problems before taking Triumeq. You may need special monitoring.
  • Tell your doctor about all medications, including over-the-counter drugs and supplements, as some may interact with Triumeq.
  • Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as the effects on the baby are not fully known.
  • Expect regular blood tests to monitor for potential side effects or health changes while on Triumeq.

You can buy Triumeq tablets at pharmacies with a prescription from your doctor.

In the United States, the pricing is notably higher, averaging around $3,956 for a supply of 30 tablets regardless of the specific dosage combination. For Pharma Giant in Canada, the pricing for Triumeq tablets is as follows:
  • 50mg/600mg/300mg – 30 tablets: $1,512.62
  • 50mg/600mg/300mg – 60 tablets: $2,991.80
  • 50mg/600mg/300mg – 90 tablets: $4,434.81
  • 600mg/50mg/300mg – 30 tablets: $2,543.23

Triumeq usually takes 3 to 6 months to reduce the level of HIV in your blood to undetectable levels. Your doctor will monitor your progress with regular blood tests and can give you more specific information on how quickly Triumeq may work for you.

Triumeq is manufactured by ViiV Healthcare, a global specialist HIV company established in November 2009.

Triumeq can cause serious kidney problems, including decreased kidney function. In clinical trials, a small percentage of people experienced kidney-related side effects. Symptoms of kidney problems can include swelling in the feet or legs.

If you stop taking Triumeq without your doctor’s advice, it can be dangerous. Your blood pressure could drop to a life-threatening level within hours, which could result in death. You should also never take medicines containing dolutegravir again.

When using Triumeq, avoid certain medications and supplements. Consult your HIV doctor or pharmacist before taking antibiotics, antiepileptic drugs, or herbal remedies like St. John’s Wort. Triumeq may affect metformin levels, potentially requiring a dosage adjustment if you’re using it for diabetes. Remember, calcium, iron, magnesium, and aluminum can hinder Triumeq absorption, so take any multivitamins, mineral supplements, or antacids at least six hours before or two hours after Triumeq.

The best time to take Triumeq is once a day, either with or without food. It’s important to take it around the same time every day to maintain consistent levels in your body.

If you overdose on Triumeq, it can lead to serious side effects. Too much abacavir and lamivudine can cause mitochondrial toxicity and lactic acidosis. However, overdosing on dolutegravir seems to have fewer harmful effects.

Pregnant women should avoid taking Triumeq unless they are also taking folic acid supplements. It’s especially important not to use Triumeq when you first become pregnant or during the first 12 weeks of pregnancy.

Yes, Triumeq is an antiretroviral medication used to treat HIV. It combines three different antiretroviral drugs into one pill. The pill contains 50mg of dolutegravir, 600mg of abacavir, and 300mg of lamivudine.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

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  • The competitor’s price must be current and active (not from a past or future promotion).
  • The product must be identical in strength, pack size, quantity, manufacturer, and country of origin.
  • Requests must be submitted before placing an order — adjustments cannot be made after purchase.
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Note: Price matching does not currently apply to Mounjaro® , Ozempic® or Saxenda®. However, this policy may be updated in the future.
Kenneth Fill, PharmD, MBA Fill

Kenneth Fill, PharmD, MBA, is a clinical pharmacist specialist and medical writer with a strong background in ambulatory care, pharmacogenomics, and medical content development. Based in the state of Michigan, he provides expert guidance on chronic disease state management. Kenneth completed his PharmD and MBA at the University of Toledo and pursued post-graduate residency training in ambulatory care and community-based pharmacy. His diverse background also includes academic detailing, clinical education, and interdisciplinary collaboration to enhance patient outcomes.