
What is Trulicity?
Trulicity is a once-weekly injectable antidiabetic medication that is used to control blood sugar levels in patients with type 2 diabetes. It belongs to a drug class called a glucagon-like peptide-1 (GLP-1) agonist; it is not insulin.
This medication should be used with diet and exercise to improve blood sugar levels in patients with type 2 diabetes. Trulicity is also used to reduce the risk of serious heart problems, such as stroke and heart attack, in adults who have type 2 diabetes and heart disease.
Trulicity is not prescribed in the treatment of type 1 diabetes.
Indications and Benefits of Trulicity
Trulicity is a once-weekly injectable medication used to help manage blood sugar levels in adults with type 2 diabetes.
It works best when combined with healthy eating and regular exercise.
Trulicity also helps lower the risk of serious heart-related problems in adults who have both type 2 diabetes and heart disease. It is not used for type 1 diabetes.
What Are the Benefits of Trulicity?
- Trulicity helps lower blood sugar levels in adults with type 2 diabetes.
- It works together with diet and exercise to improve blood sugar control.
- It is taken only once a week, which makes it easier for many patients to follow.
- It helps reduce the risk of major heart problems, such as heart attack and stroke, in people with type 2 diabetes and heart disease.
- Trulicity may support weight loss for some patients while improving blood sugar levels.
- It provides steady and long-lasting control of blood sugar throughout the week.
How Trulicity Works
Trulicity works by mimicking the action of GLP-1.
GLP-1 is a natural hormone within the body that helps to regulate blood sugar levels.
It works by binding to GLP-1 receptors, therefore, increasing insulin production and lowering sugar secretion from the liver, and slowing stomach emptying.
Trulicity has also been known to reduce the risk of cardiovascular events in adults with type 2 diabetes who also have cardiovascular disease.
Fact Table
| Fact Category | Fact Details |
| Generic Name | Dulaglutide |
| Medication Class | Glucagon-like peptide 1 (GLP-1) receptor agonist |
| Primary Use | Management of blood sugar in adults with type 2 diabetes |
| Additional Benefit | Lowers the risk of serious heart problems such as heart attack and stroke |
| Available Form | Prefilled pen for injection |
| Method of Administration | Subcutaneous injection under the skin |
| Frequency | Once a week |
| Storage Instructions | Store in the refrigerator at 36F to 46F (2C to 8C). Do not freeze. Can be kept at room temperature for up to 14 days if needed |
| Pregnancy and Breastfeeding | Not recommended during pregnancy or breastfeeding unless advised by a doctor |
| Drug Interactions | May interact with other medicines, supplements, or herbal products. Inform your healthcare provider about everything you are taking |
| Manufacturer | Eli Lilly and Company |
Dosage
Trulicity is available in the form of a single-dose pen in the following strengths.
- 75 mg/0.5 mL solution in a single-dose pen
- 5 mg/0.5 mL solution in a single-dose pen
- 3 mg/0.5 mL solution in a single-dose pen
- 5 mg/0.5 mL solution in a single-dose pen
Dosing for Adults
The recommended starting dose is 0.75 mg injected subcutaneously (under the skin) once weekly.
The dose can be increased to 1.5mg once weekly as needed for additional blood sugar control.
The dose can further be increased to 3 mg once weekly after four weeks on the 1.5 mg dose. If further blood sugar control is needed, the dose can be increased to 4.5 mg once weekly after 4 weeks on the 3mg dose.
The maximum weekly dose of Trulicity is 4.5 mg weekly.
For pediatric dosing, Canada and the United States differ. The following are updates to match US labeling.
Dosing for Children
- Trulicity is approved for patients 10 years and older.
- The recommended starting dose is 0.75mg injected subcutaneously (under the skin) once weekly.
- If additional blood sugar control is needed after 4 weeks, the dose can be increased to 1.5mg once weekly.
Dosage Chart
| Population | Use | Starting Dose | Additional Information | Maximum Weekly Dose |
| Adults age 18 and older | Type 2 diabetes | 0.75 milligrams once a week | Your healthcare provider makes dose adjustments based on blood sugar control and tolerance. | 4.5 milligrams |
| Children and teens age 10 to 17 | Type 2 diabetes | 0.75 milligrams once a week | Your healthcare provider makes dose adjustments if more blood sugar control is needed | 1.5 milligrams |
| Children under age 10 | Type 2 diabetes | Not approved | Not applicable | Not applicable |
| Older adults | Type 2 diabetes | 0.75 milligrams once a week | Follow adult dosing guidance under supervision | 4.5 milligrams |
| People with kidney or liver problems | Type 2 diabetes | 0.75 milligrams once a week | Follow adult dosing guidance under supervision | 4.5 milligrams |
Usage Guide
Trulicity comes in a once-weekly injectable pen. The pen is easy to self-administer and should be injected subcutaneously once a week into the stomach, thigh, or upper arm.
Medication can be administered at any time of day, but should be given on the same day weekly, and the time should be kept as consistent as possible.
Injection sites should be rotated with each use. Each pen contains a single dose and should be discarded into a sharps container after use.
How to administer Trulicity?
- Remove the Trulicity pen from the refrigerator and keep the base cap on until you are ready to inject.
- Check the pen label to ensure it is the correct medication and not expired. Inspect the liquid to make sure it is clear and free of particles.
- Wash your hands thoroughly with soap and water.
- Choose your injection site. You may inject into your stomach, thigh, or the back of your upper arm. Rotate the injection site each week and avoid using the same exact spot.
- Remove the base cap from the pen and throw it away. Do not touch the needle or put the cap back on.
- Place the clear base of the pen flat and firmly against your skin at the injection site.
- Unlock the pen by turning the lock ring.
- Press and hold the green injection button. You will hear a click when the injection starts. Keep the pen in place until you hear a second click, which means the needle has retracted.
- Remove the pen from your skin.
- Dispose of the used pen immediately in an FDA-cleared sharps container. If you do not have a sharps container, use a sturdy plastic container with a tight-fitting lid, label it clearly, and follow local disposal guidelines.
- Store your pen in the refrigerator until the next use. You may keep it at room temperature for up to 14 days. Protect it from heat and light and keep it out of reach of children.
Side Effects
If you experience signs and symptoms of an allergic reaction, such as hives, rash, itching, difficulty breathing, or swelling of the face, mouth, or throat, seek medical attention immediately.
Common side effects:
- Nausea, vomiting or stomach pain
- Diarrhea
- Loss of appetite
- Injection site discomfort
Severe side effects:
- Severe pain in your upper stomach that spreads to your back, nausea, and vomiting (signs of pancreatitis)
- Swelling or lump in the neck, trouble swallowing, a hoarse voice,e or shortness of breath (signs of a thyroid tumor)
- Headache, hunger, weakness, sweating, confusion, irritability, fast heart rate, or feeling jittery (signs of low blood sugar)
- Little or no urination, lower extremity swelling, fatigue,e and shortness of breath (signs of kidney problems)
- Increased vomiting or diarrhea, increased sweating (signs of dehydration that can lead to kidney failure)
The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects that are not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.
Comparing Trulicity vs. Other GLP-1 Treatments?
| Feature | Trulicity (Dulaglutide) | Ozempic / Wegovy (Semaglutide) | Victoza (Liraglutide) |
| Drug Class | GLP-1 receptor agonist | GLP-1 receptor agonist | GLP-1 receptor agonist |
| Approved Uses | Type 2 diabetes may reduce heart risk | Ozempic: Type 2 diabetes; Wegovy: Weight management | Type 2 diabetes |
| Injection Frequency | Once a week | Once a week | Once a day |
| Injection Site | Under the skin (abdomen, thigh, upper arm) | Under the skin | Under the skin |
| Starting Dose | 0.75 mg weekly | 0.25 mg weekly | 0.6 mg daily |
| Maximum Dose | 4.5 mg weekly | Ozempic: 2 mg weekly; Wegovy: 2.4 mg weekly | 1.8 mg daily |
| Blood Sugar Control | Steady and reliable | Stronger overall | Moderate |
| Weight Loss Potential | Mild to moderate | Moderate to significant | Moderate |
| Typical Weight Loss | Around 3 to 6 percent | Around 8 to 15 percent or more | Around 5 to 10 percent |
| Appetite Reduction | Moderate | Strong | Moderate |
| Common Side Effects | Nausea, diarrhea, vomiting | Nausea, vomiting, diarrhea, constipation | Nausea, stomach upset |
| Side Effects Over Time | Often improves as the body adjusts | May increase at higher doses | Can be more frequent due to daily use |
| Heart Health Benefits | Yes, for some patients | Yes, strong evidence | Some evidence |
| Ease of Use | Simple weekly routine | Weekly dosing with gradual increases | Daily injections may be less convenient |
| Long-Term Comfort | Usually well tolerated | Effective but dose increases may be needed | Less convenient for long-term daily use |
| Typical Cost Range | Moderate | Higher than Trulicity | Moderate to high |
Missed Dose
If you miss a dose, administer it as soon as possible if there are at least three days or 72 hours until your next scheduled dose. If less than 3 days until your next scheduled dose, skip the missed dose and administer the next dose on your regularly scheduled day. Do not take 2 doses within 72 hours.
Overdose
If you take too much Trulicity, serious side effects can occur including significant hypoglycemia.
If you suspect an overdose, seek emergency medical attention or call the poison control helpline at 1-800-222-1222.
Storage
Trulicity should be kept in the refrigerator between two and eight degrees Celsius until you are ready to use it. You can leave it at room temperature below thirty degrees Celsius for up to fourteen days. After fourteen days at room temperature, it must be discarded.
Warnings & Precautions
Trulicity is contraindicated in those with a known allergy or sensitivity to any of its ingredients.
Pregnancy and Breastfeeding
Trulicity is not recommended in pregnant or breastfeeding women. No studies have been performed to test the safety and efficacy of these patients.
Type 1 Diabetes
Trulicity is not indicated in the treatment of type 1 diabetes.
Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2)
Trulicity is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).
Pancreatitis
Pancreatitis has been reported in some patients who have taken it. Patients should be monitored for signs and symptoms of pancreatitis, including persistent, severe abdominal pain that radiates to the back and vomiting. Other antidiabetic therapies should be considered in patients with a history of pancreatitis.
Hypoglycemia
Patients who take Trulicity with an insulin secretagogue (sulfonylurea) or insulin may have an increased risk of hypoglycemia. Patients should be monitored for hypoglycemia while taking these medications in combination.
Hypersensitivity Reactions
Patients who have taken Trulicity have reported anaphylactic reactions and angioedema. It should be discontinued immediately if a hypersensitivity reaction occurs. Caution should be used in patients with a history of angioedema or anaphylaxis with another GLP-1 receptor agonist.
Acute Kidney Injury
Patients who have taken GLP-1 receptor agonists like Trulicity have developed acute renal failure or worsening of chronic renal failure, sometimes requiring hemodialysis. Caution should be used when using in patients with known renal failure.
Severe Gastrointestinal Disease
Trulicity has been associated with adverse gastrointestinal reactions, including severe gastroparesis. Caution should be used in patients with known gastrointestinal diseases.
Diabetic Retinopathy
Complications related to diabetic retinopathy have been reported in patients taking this medication. Patients with a history of diabetic retinopathy should be monitored for worsening of the disease while taking it.
Drug Interactions
This is not a complete list of potential drug interactions. Before taking medication, tell your doctor if you take any medications, herbal supplements, or vitamins.
Bexarotene
Bexarotene is a cancer treatment for cutaneous T-cell lymphomas. Bexarotene when used with Trulicity can increase the risk of pancreatitis. Alternative medications should be considered. If alternative medications are not appropriate, close patient monitoring is recommended.
Gatifloxacin
Gatifloxacin is an eye drop used in the treatment of bacterial conjunctivitis. Gatifloxacin when used with Trulicity can affect blood sugar levels and should not be used in patients with diabetes.
Trulicity Discounts & Costs
Order Trulicity Online from Canada at the LOW PRICE
For many in the United States, the cost of managing conditions like diabetes can be overwhelming, particularly when it comes to essential medications such as Trulicity. Without insurance, the price for 4 Trulicity pens can surpass $1,100, creating a significant financial challenge.
Fortunately, Pharma Giant offers a more budget-friendly solution. As a leading provider, Pharma Giant enables patients to access Trulicity at substantially lower prices.
Through Pharma Giant, the cost for 4 Trulicity pens is just $282, offering considerable savings. For those needing larger quantities, the deal gets even better – 12 pens are available for $831, allowing for even greater cost efficiency.
Coupon for Trulicity
Discount Code Special Offer: To make healthcare expenses more manageable, Pharma Giant is offering an exclusive discount.
By applying the coupon code TRULCITY10 at checkout, customers can enjoy a 10% discount on their Trulicity purchase. This offer requires a minimum spend of $100 and allows for maximum savings of $50, further reducing the financial burden.
By choosing Pharma Giant for your Trulicity needs, patients in the US can significantly alleviate the financial pressure of procuring their diabetes medication.
This opportunity ensures that more individuals have access to necessary treatments at prices that won’t break the bank, especially valuable for those without insurance coverage.
Frequently Asked Questions
Buying Trulicity from Canada
FDA-Prescription, Off-Label Information, and Limitations
Dosage & Administration
Adverse Reactions
Food & Drug Interactions
Storage & Travel
Drug Comparison
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.






