Trulicity
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Trulicity Dulaglutide
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What is Trulicity?

Trulicity is a once-weekly injectable antidiabetic medication that is used to control blood sugar levels in patients with type 2 diabetes. It belongs to a drug class called a glucagon-like peptide-1 (GLP-1) agonist; it is not insulin.

This medication should be used with diet and exercise to improve blood sugar levels in patients with type 2 diabetes. Trulicity is also used to reduce the risk of serious heart problems, such as stroke and heart attack, in adults who have type 2 diabetes and heart disease.

Trulicity is not prescribed in the treatment of type 1 diabetes.

Indications and Benefits of Trulicity

Trulicity is a once-weekly injectable medication used to help manage blood sugar levels in adults with type 2 diabetes.

It works best when combined with healthy eating and regular exercise.

Trulicity also helps lower the risk of serious heart-related problems in adults who have both type 2 diabetes and heart disease. It is not used for type 1 diabetes.

What Are the Benefits of Trulicity?

  • Trulicity helps lower blood sugar levels in adults with type 2 diabetes.
  • It works together with diet and exercise to improve blood sugar control.
  • It is taken only once a week, which makes it easier for many patients to follow.
  • It helps reduce the risk of major heart problems, such as heart attack and stroke, in people with type 2 diabetes and heart disease.
  • Trulicity may support weight loss for some patients while improving blood sugar levels.
  • It provides steady and long-lasting control of blood sugar throughout the week.

How Trulicity Works

Trulicity works by mimicking the action of GLP-1.

GLP-1 is a natural hormone within the body that helps to regulate blood sugar levels.

It works by binding to GLP-1 receptors, therefore, increasing insulin production and lowering sugar secretion from the liver, and slowing stomach emptying.

Trulicity has also been known to reduce the risk of cardiovascular events in adults with type 2 diabetes who also have cardiovascular disease.

Fact Table

Fact Category Fact Details
Generic Name Dulaglutide
Medication Class Glucagon-like peptide 1 (GLP-1) receptor agonist
Primary Use Management of blood sugar in adults with type 2 diabetes
Additional Benefit Lowers the risk of serious heart problems such as heart attack and stroke
Available Form Prefilled pen for injection
Method of Administration Subcutaneous injection under the skin
Frequency Once a week
Storage Instructions Store in the refrigerator at 36F to 46F (2C to 8C). Do not freeze. Can be kept at room temperature for up to 14 days if needed
Pregnancy and Breastfeeding Not recommended during pregnancy or breastfeeding unless advised by a doctor
Drug Interactions May interact with other medicines, supplements, or herbal products. Inform your healthcare provider about everything you are taking
Manufacturer Eli Lilly and Company

Dosage

Trulicity is available in the form of a single-dose pen in the following strengths.

  • 75 mg/0.5 mL solution in a single-dose pen
  • 5 mg/0.5 mL solution in a single-dose pen
  • 3 mg/0.5 mL solution in a single-dose pen
  • 5 mg/0.5 mL solution in a single-dose pen

Dosing for Adults

The recommended starting dose is 0.75 mg injected subcutaneously (under the skin) once weekly.

The dose can be increased to 1.5mg once weekly as needed for additional blood sugar control. 

The dose can further be increased to 3 mg once weekly after four weeks on the 1.5 mg dose. If further blood sugar control is needed, the dose can be increased to 4.5 mg once weekly after 4 weeks on the 3mg dose.

The maximum weekly dose of Trulicity is 4.5 mg weekly.

For pediatric dosing, Canada and the United States differ. The following are updates to match US labeling.

Dosing for Children

  • Trulicity is approved for patients 10 years and older.
  • The recommended starting dose is 0.75mg injected subcutaneously (under the skin) once weekly.
  • If additional blood sugar control is needed after 4 weeks, the dose can be increased to 1.5mg once weekly.

Dosage Chart

Population Use Starting Dose Additional Information Maximum Weekly Dose
Adults age 18 and older Type 2 diabetes 0.75 milligrams once a week Your healthcare provider makes dose adjustments based on blood sugar control and tolerance. 4.5 milligrams
Children and teens age 10 to 17 Type 2 diabetes 0.75 milligrams once a week Your healthcare provider makes dose adjustments if more blood sugar control is needed 1.5 milligrams
Children under age 10 Type 2 diabetes Not approved Not applicable Not applicable
Older adults Type 2 diabetes 0.75 milligrams once a week Follow adult dosing guidance under supervision 4.5 milligrams
People with kidney or liver problems Type 2 diabetes 0.75 milligrams once a week Follow adult dosing guidance under supervision 4.5 milligrams

Usage Guide

Trulicity comes in a once-weekly injectable pen. The pen is easy to self-administer and should be injected subcutaneously once a week into the stomach, thigh, or upper arm.

Medication can be administered at any time of day, but should be given on the same day weekly, and the time should be kept as consistent as possible.

Injection sites should be rotated with each use. Each pen contains a single dose and should be discarded into a sharps container after use.

How to administer Trulicity?

  1. Remove the Trulicity pen from the refrigerator and keep the base cap on until you are ready to inject.
  2. Check the pen label to ensure it is the correct medication and not expired. Inspect the liquid to make sure it is clear and free of particles.
  3. Wash your hands thoroughly with soap and water.
  4. Choose your injection site. You may inject into your stomach, thigh, or the back of your upper arm. Rotate the injection site each week and avoid using the same exact spot.
  5. Remove the base cap from the pen and throw it away. Do not touch the needle or put the cap back on.
  6. Place the clear base of the pen flat and firmly against your skin at the injection site.
  7. Unlock the pen by turning the lock ring.
  8. Press and hold the green injection button. You will hear a click when the injection starts. Keep the pen in place until you hear a second click, which means the needle has retracted.
  9. Remove the pen from your skin.
  10. Dispose of the used pen immediately in an FDA-cleared sharps container. If you do not have a sharps container, use a sturdy plastic container with a tight-fitting lid, label it clearly, and follow local disposal guidelines.
  11. Store your pen in the refrigerator until the next use. You may keep it at room temperature for up to 14 days. Protect it from heat and light and keep it out of reach of children.

Side Effects

If you experience signs and symptoms of an allergic reaction, such as hives, rash, itching, difficulty breathing, or swelling of the face, mouth, or throat, seek medical attention immediately.

Common side effects:

  • Nausea, vomiting or stomach pain
  • Diarrhea
  • Loss of appetite
  • Injection site discomfort

Severe side effects:

  • Severe pain in your upper stomach that spreads to your back, nausea, and vomiting (signs of pancreatitis)
  • Swelling or lump in the neck, trouble swallowing, a hoarse voice,e or shortness of breath (signs of a thyroid tumor)
  • Headache, hunger, weakness, sweating, confusion, irritability, fast heart rate, or feeling jittery (signs of low blood sugar)
  • Little or no urination, lower extremity swelling, fatigue,e and shortness of breath (signs of kidney problems)
  • Increased vomiting or diarrhea, increased sweating (signs of dehydration that can lead to kidney failure)

The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects that are not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.

Comparing Trulicity vs. Other GLP-1 Treatments?

Feature Trulicity (Dulaglutide) Ozempic / Wegovy (Semaglutide) Victoza (Liraglutide)
Drug Class GLP-1 receptor agonist GLP-1 receptor agonist GLP-1 receptor agonist
Approved Uses Type 2 diabetes may reduce heart risk Ozempic: Type 2 diabetes; Wegovy: Weight management Type 2 diabetes
Injection Frequency Once a week Once a week Once a day
Injection Site Under the skin (abdomen, thigh, upper arm) Under the skin Under the skin
Starting Dose 0.75 mg weekly 0.25 mg weekly 0.6 mg daily
Maximum Dose 4.5 mg weekly Ozempic: 2 mg weekly; Wegovy: 2.4 mg weekly 1.8 mg daily
Blood Sugar Control Steady and reliable Stronger overall Moderate
Weight Loss Potential Mild to moderate Moderate to significant Moderate
Typical Weight Loss Around 3 to 6 percent Around 8 to 15 percent or more Around 5 to 10 percent
Appetite Reduction Moderate Strong Moderate
Common Side Effects Nausea, diarrhea, vomiting Nausea, vomiting, diarrhea, constipation Nausea, stomach upset
Side Effects Over Time Often improves as the body adjusts May increase at higher doses Can be more frequent due to daily use
Heart Health Benefits Yes, for some patients Yes, strong evidence Some evidence
Ease of Use Simple weekly routine Weekly dosing with gradual increases Daily injections may be less convenient
Long-Term Comfort Usually well tolerated Effective but dose increases may be needed Less convenient for long-term daily use
Typical Cost Range Moderate Higher than Trulicity Moderate to high

Missed Dose

If you miss a dose, administer it as soon as possible if there are at least three days or 72 hours until your next scheduled dose. If less than 3 days until your next scheduled dose, skip the missed dose and administer the next dose on your regularly scheduled day. Do not take 2 doses within 72 hours.

Overdose

If you take too much Trulicity, serious side effects can occur including significant hypoglycemia.

If you suspect an overdose, seek emergency medical attention or call the poison control helpline at 1-800-222-1222.

Storage

Trulicity should be kept in the refrigerator between two and eight degrees Celsius until you are ready to use it. You can leave it at room temperature below thirty degrees Celsius for up to fourteen days. After fourteen days at room temperature, it must be discarded.

Warnings & Precautions

Trulicity is contraindicated in those with a known allergy or sensitivity to any of its ingredients.

Pregnancy and Breastfeeding

Trulicity is not recommended in pregnant or breastfeeding women. No studies have been performed to test the safety and efficacy of these patients.

Type 1 Diabetes

Trulicity is not indicated in the treatment of type 1 diabetes.

Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2)

Trulicity is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2).

Pancreatitis

Pancreatitis has been reported in some patients who have taken it. Patients should be monitored for signs and symptoms of pancreatitis, including persistent, severe abdominal pain that radiates to the back and vomiting. Other antidiabetic therapies should be considered in patients with a history of pancreatitis.

Hypoglycemia

Patients who take Trulicity with an insulin secretagogue (sulfonylurea) or insulin may have an increased risk of hypoglycemia. Patients should be monitored for hypoglycemia while taking these medications in combination.

Hypersensitivity Reactions

Patients who have taken Trulicity have reported anaphylactic reactions and angioedema. It should be discontinued immediately if a hypersensitivity reaction occurs. Caution should be used in patients with a history of angioedema or anaphylaxis with another GLP-1 receptor agonist.

Acute Kidney Injury

Patients who have taken GLP-1 receptor agonists like Trulicity have developed acute renal failure or worsening of chronic renal failure, sometimes requiring hemodialysis. Caution should be used when using in patients with known renal failure.

Severe Gastrointestinal Disease

Trulicity has been associated with adverse gastrointestinal reactions, including severe gastroparesis. Caution should be used in patients with known gastrointestinal diseases.

Diabetic Retinopathy

Complications related to diabetic retinopathy have been reported in patients taking this medication. Patients with a history of diabetic retinopathy should be monitored for worsening of the disease while taking it.

Drug Interactions

This is not a complete list of potential drug interactions. Before taking medication, tell your doctor if you take any medications, herbal supplements, or vitamins.

Bexarotene

Bexarotene is a cancer treatment for cutaneous T-cell lymphomas. Bexarotene when used with Trulicity can increase the risk of pancreatitis. Alternative medications should be considered. If alternative medications are not appropriate, close patient monitoring is recommended.

Gatifloxacin

Gatifloxacin is an eye drop used in the treatment of bacterial conjunctivitis. Gatifloxacin when used with Trulicity can affect blood sugar levels and should not be used in patients with diabetes.

Alternative Medications

Amylin Analogs

  • Symlin

GLP-1 Agonists

Insulin

Trulicity Discounts & Costs

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For many in the United States, the cost of managing conditions like diabetes can be overwhelming, particularly when it comes to essential medications such as Trulicity. Without insurance, the price for 4 Trulicity pens can surpass $1,100, creating a significant financial challenge.

Fortunately, Pharma Giant offers a more budget-friendly solution. As a leading provider, Pharma Giant enables patients to access Trulicity at substantially lower prices.

Through Pharma Giant, the cost for 4 Trulicity pens is just $282, offering considerable savings. For those needing larger quantities, the deal gets even better – 12 pens are available for $831, allowing for even greater cost efficiency.

Coupon for Trulicity

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By applying the coupon code TRULCITY10 at checkout, customers can enjoy a 10% discount on their Trulicity purchase. This offer requires a minimum spend of $100 and allows for maximum savings of $50, further reducing the financial burden.

By choosing Pharma Giant for your Trulicity needs, patients in the US can significantly alleviate the financial pressure of procuring their diabetes medication.

This opportunity ensures that more individuals have access to necessary treatments at prices that won’t break the bank, especially valuable for those without insurance coverage.

Frequently Asked Questions

Buying Trulicity from Canada

Yes, you need a prescription from your doctor to order Trulicity.
Yes, it is legal to buy Trulicity from Canada. You can order a supply for up to three months as long as it is prescribed to you and does not pose an unreasonable health risk.
To place an order, do the following steps:
  1. Add Trulicity to your cart.
  2. When ready, proceed to checkout, where new customers can register and existing customers can log in.
  3. After checkout, upload or send your prescription using the website, email, or fax.
  4. Once your prescription is verified, your order will be shipped with a tracking number so you can follow it until it arrives at your door.
You can submit your prescription by uploading it using the RX document uploader on our website, or by sending it via email or fax.
You can easily order refills through your customer profile, where any available refills are listed. When placing a refill, keep in mind our 30-day shipping rule. You can place an order at any time, but we may hold it until 30 days from your previous order have passed.
Yes, the Trulicity you receive from us is the same as what you would get at your local pharmacy. It contains the same active ingredient, dulaglutide, and meets the same quality and FDA-approved safety standards.
Trulicity is shipped using Canada Post Express with a tracking number so you can follow your package. Medications that require temperature control are sent in insulated boxes with gel packs to ensure they remain at the proper temperature during transit.
The shipping cost for Trulicity from Canada is $29.99, as it is a cold-chain shipment. This fee covers insulated packaging and temperature control during transit to help ensure the product arrives in proper condition.
Orders typically arrive within 4 to 10 business days. To avoid delays, especially during holidays, it’s recommended to order 30 to 45 days before you need your medication.

FDA-Prescription, Off-Label Information, and Limitations

Trulicity is not approved for the treatment of type 1 diabetes.
Trulicity is not approved for weight loss. It is prescribed to help manage blood sugar levels in people with type 2 diabetes. While some people may notice modest weight loss while using Trulicity, this happens as a side effect, not as its main purpose.
It is not recommended for people who have had a rare thyroid cancer called medullary thyroid carcinoma (MTC) or an inherited condition called multiple endocrine neoplasia type 2 (MEN 2), which increases the risk of tumors in glands like the thyroid or adrenal glands.
Patients with a history of pancreatitis should utilize other antidiabetic therapies to avoid recurrent pancreatitis.
Trulicity is not recommended for use during pregnancy. Dulaglutide, the active ingredient in Trulicity, has not been studied enough in pregnant people to know if it could cause congenital disabilities or miscarriages.
Trulicity is not recommended for women who are breastfeeding. Manufacturers advise against its use because it could affect a baby’s developing kidneys. Since there is not enough research on the safety of dulaglutide while nursing, it is best to avoid using it during this time
Trulicity can be used in children and adolescents aged 10 years and older. It is not studied in children under 10. The usual starting dose is 0.75 mg injected under the skin once a week, which can be increased to 1.5 mg after 4 weeks if more blood sugar control is needed.

Dosage & Administration

Inject Trulicity under the skin once a week into the stomach, thigh, or upper arm. You can give it at any time of day, but choose the same day each week and try to keep the time consistent. Rotate injection sites with each use. Each pen contains a single dose and should be discarded into a sharps container after use.
If you miss a dose of Trulicity, take it as soon as possible if there are at least three days (72 hours) before your next scheduled dose. If less than three days remain, skip the missed dose and take your next dose on the regularly scheduled day. Do not take two doses within 72 hours.
Do not take more than one dose of Trulicity within 72 hours. Taking too much too soon can increase your risk of side effects, such as nausea or diarrhea.

Adverse Reactions

The most common side effects of Trulicity are nausea, diarrhea, vomiting, stomach pain, decreased appetite, indigestion, and fatigue.
Trulicity is not FDA-approved for weight loss, but it can help reduce appetite and food intake, which may lead to weight loss in people with type 2 diabetes or obesity. In clinical trials, weight change was only measured as a secondary outcome.
Yes, Trulicity can cause a reduced appetite, which is a known effect of the treatment.

Food & Drug Interactions

Yes, Trulicity can be used with metformin. They work in different ways to help control blood sugar: Trulicity increases insulin from the pancreas, while metformin improves insulin sensitivity and lowers glucose production. Your doctor may recommend using them together if the benefits outweigh the risks.

Storage & Travel

Yes, Trulicity should be stored in the refrigerator until use. However, it can be kept at room temperature below 86 degrees Fahrenheit for up to 14 days.
Trulicity can stay out of the refrigerator at room temperature for up to 14 days.

Drug Comparison

No, Trulicity and Ozempic are not interchangeable because they contain different active ingredients; Trulicity has dulaglutide, and Ozempic has semaglutide. While both treat type 2 diabetes and belong to the same drug class, they work slightly differently, and Ozempic may lower blood sugar and support weight loss more effectively. Your doctor will decide which is right for you.
Medications similar to Trulicity include other GLP-1 receptor agonists, including Ozempic and Rybelsus (semaglutide), Victoza (liraglutide), and Bydureon or Byetta (exenatide). These drugs work in similar ways to control blood sugar by slowing digestion and stimulating insulin release.

Disclaimer

Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.

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Price Match Guarantee

We are committed to providing fair, competitive pricing on all medications. If you find a lower price on the same product at another verified Canadian online pharmacy, we’ll match it.

Eligibility Criteria

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  • The competitor’s price must be current and active (not from a past or future promotion).
  • The product must be identical in strength, pack size, quantity, manufacturer, and country of origin.
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Note: Price matching does not currently apply to Mounjaro® , Ozempic® or Saxenda®. However, this policy may be updated in the future.

Jakob Leaderbrand, PharmD, CSP

Jakob Leaderbrand, PharmD, is a licensed pharmacist with extensive experience in specialty pharmacy and clinical program management. Based in the Kansas City metro area, he holds a Doctor of Pharmacy degree from the University of Missouri-Kansas City and a Specialty Pharmacy Certification. Currently, Jakob works in Specialty Pharmacy, where he leverages his clinical expertise to drive adherence, improve patient outcomes, and ensure compliance through effective communication of complex data insights. Jakob is known for his commitment to operational excellence and for leading initiatives that streamline patient assessments and enhance audit compliance, making a significant impact on patient care and client relationships in the pharmacy sector.