
What is Truxima?
Truxima (rituximab-abbs) is a prescription medication used to treat certain types of cancer and autoimmune diseases.
Truxima is often used to treat non-Hodgkin lymphoma (a cancer that affects white blood cells), chronic lymphocytic leukemia, and rheumatoid arthritis. Doctors also use it to treat rare diseases that affect blood vessels, such as granulomatosis with polyangiitis and microscopic polyangiitis.
The Truxima dose depends on the treated condition, your body size, and how you respond to the medication.
Your doctor carefully plans the Truxima dosage, which may involve several treatments over weeks or months. Depending on the disease and how well your body responds, your Truxima dosing schedule could include a single infusion weekly or every few months.
It is important to follow this schedule closely, as it helps the medication work best and lowers the risk of side effects. Always talk to your doctor or nurse if you have questions about your dose or when to get your next infusion.
How Does Truxima Work?
Truxima is a treatment that finds and sticks to a protein called CD20 on specific white blood cells called B cells.
These B cells can cause problems with cancers and immune system diseases. In cancer, B cells grow too fast. In autoimmune diseases, B cells cause swelling and damage in the body.
Truxima helps by removing these B cells from the body. This can slow down cancer and reduce swelling and pain in autoimmune diseases.
It may start working after the first treatment, but feeling better can take a few treatments.
Truxima Dosage Information and Administration
Truxima is an intravenous infusion solution available in single-dose vials at strengths of 100 mg/10 mL and 500 mg/50 mL.
Truxima is given through a vein, usually in the arm, by a healthcare provider in a clinic, hospital, or doctor’s office.
This method ensures controlled dose delivery over time for safe and effective treatment.
Dosage Form and Strengths of Truxima
Truxima is supplied as a liquid solution for infusion. The main strengths include:
- 100 mg per 10 mL vial
- 500 mg per 50 mL vial
These doses allow flexibility depending on the treatment plan.
Truxima Administered
Truxima is given as an intravenous infusion following these steps:
- A healthcare provider prepares the dose based on your body size and condition.
- Pre-medication like acetaminophen and antihistamines may be given to prevent reactions.
- The infusion starts slowly, increasing gradually if no side effects occur.
- The infusion usually takes several hours, depending on the dose.
- The provider monitors you during the infusion for any reactions.
- Infusions are scheduled according to your specific treatment plan.
Recommended Dosage of Truxima
Your doctor will prescribe the Truxima dose appropriate for your condition, body size, and any other treatments you may receive.
The Truxima dosing schedule is tailored to fit your individual needs. Doctors usually begin with a low dose and adjust it over time to find the smallest dose that works well for you.
Truxima dosage is calculated for many patients based on body surface area (BSA), which considers height and weight. This approach helps ensure the correct amount is given for the best effect.
For non-Hodgkin lymphoma, a common Truxima dose is 375 mg per square meter of body surface area. Depending on your treatment type and response, this infusion may be given once a week for several weeks.
In rheumatoid arthritis, the initial Truxima dose is often 1,000 mg, followed by another two weeks later. After that, infusions usually happen every 16 to 24 weeks, depending on how your symptoms improve.
For chronic lymphocytic leukemia, the Truxima dosage starts at 375 mg per square meter before chemotherapy and then increases to 500 mg per square meter during treatment cycles.
Your doctor will carefully design your Truxima dosing schedule to balance effectiveness and safety.
It is important to follow the schedule and attend all infusion appointments. If you miss a dose, contact your doctor as soon as possible to reschedule.
Truxima Side Effects
Truxima side effects can range from common mild symptoms to severe health problems. Some common side effects include fever, chills, and nausea. More serious side effects may involve heart problems, kidney issues, or severe allergic reactions. It is important to know the usual and severe side effects when receiving Truxima treatment, especially because some side effects can be life-threatening.
Common Side Effects
- Mild infusion reactions, such as itchy skin
- Fever and chills
- Infections such as sinus, lung, or bladder infections
- Herpes infections cause cold sores
- Feeling weak or tired
- Body aches and headaches
- Nausea and diarrhea
- Muscle spasms or twitches
- Joint pain and swelling in the arms or legs
- Rash on the skin
Severe Side Effects
- Tumor lysis syndrome (symptoms: nausea, vomiting, diarrhea, weakness)
- Heart problems (symptoms: chest pain, irregular heartbeat, trouble breathing)
- Kidney problems, including kidney failure (symptoms: less urine, swelling in legs, tiredness)
- Serious stomach and bowel problems (symptoms: severe pain, vomiting, constipation)
- Reactivation of hepatitis B virus (symptoms: fatigue, yellow skin or eyes)
- Rare brain infection called progressive multifocal leukoencephalopathy (PML) (symptoms: confusion, dizziness, vision changes)
- Severe allergic reactions or severe infusion reactions, such as chest pain
- Severe infections such as pneumonia
- Severe skin and mucous membrane reactions
Warnings and Precautions for Truxima
Truxima can cause serious and sometimes life-threatening side effects. Before starting this medication, your doctor will check your health to help reduce the risk of these problems.
During treatment, your doctor will continue to watch for any warning signs to keep you as safe as possible. It is important to understand these risks and follow your doctor’s advice closely.
- Truxima can cause severe and sometimes fatal infusion-related reactions, especially during the first dose. Symptoms may include rash, low blood pressure, swelling, trouble breathing, or chest pain.
- Patients should take medications like antihistamines and acetaminophen before the infusion to help lower the risk of reactions. In some cases, steroids may also be given before treatment.
- If an infusion reaction happens, the doctor may stop or slow the infusion and give emergency treatments like oxygen or epinephrine.
- Truxima can cause serious skin and mouth reactions that threaten life. These reactions include rashes, peeling skin, or painful sores. Stop treatment if this occurs.
- Hepatitis B virus may reactivate in people who had it in the past. This can cause liver failure or death. Doctors test patients for hepatitis B before they start Truxima.
- If you had hepatitis B, your doctor may refer you to a liver specialist and provide antiviral medication before or during treatment. You will undergo monitoring for several months after stopping Truxima.
- Truxima can cause a rare brain infection called PML that can lead to death. It happens more often in patients with weakened immune systems. Symptoms can include confusion, memory loss, or problems with speech or movement.
- Truxima can cause tumor lysis syndrome, a serious condition where cancer cells break down quickly. This condition can lead to kidney failure or death and usually occurs within a day of the first dose.
- If you are at high risk for tumor lysis syndrome, your doctor will give you fluids and other medications to help protect your kidneys.
- Serious infections, including bacterial, fungal, or viral infections, can occur during or after Truxima treatment. These infections can be deadly and may last a long time.
- Truxima can lower the number of certain blood proteins, making it harder for your body to fight infections. If you get a serious infection, your doctor may stop treatment.
- Some people may have heart problems during or after getting Truxima, such as irregular heartbeats or heart attacks. If you have heart issues or develop symptoms during the infusion, your heart may be monitored.
- Truxima can cause severe kidney problems, especially in people with lymphoma. Kidney failure has occurred in patients receiving certain chemotherapy drugs along with Truxima.
- Truxima may cause bowel problems like pain, blockage, or even tears in the intestine. These problems can lead to death and may require emergency surgery.
- Vaccines that use live viruses should not be given before or during Truxima treatment. Non-live vaccines should be given at least four weeks before starting treatment.
- Truxima may make vaccines less effective. It can lower the body’s ability to produce antibodies in response to some vaccines.
- Truxima may harm an unborn baby. Women who are pregnant or could become pregnant should use birth control during treatment and for one year after the last dose.
- The safety of using Truxima with other biologic medications or certain arthritis drugs is unknown. If used together, there may be a higher risk of infection.
- Truxima is not recommended for patients with rheumatoid arthritis who have not already tried and failed other treatments like TNF blockers.
Truxima Drug Interactions
Truxima can interact with other drugs, which may affect how well it works or increase side effects. Some drugs are used together with Truxima to treat cancer or autoimmune diseases, while others should not be taken with it. It is important to tell your doctor about all medications, supplements, and vaccines you take before starting Truxima.
- fludarabine
- cyclophosphamide
- doxorubicin
- vincristine
- prednisone
- ibritumomab tiuxetan
- methotrexate
- methylprednisolone
- acetaminophen
- diphenhydramine
- cisplatin
- nasal spray flu vaccine
- chickenpox vaccine
- measles-mumps-rubella vaccine
Truxima Alternatives
There are other medications that can be used instead of Truxima to treat conditions like cancer or autoimmune diseases.
Some may work better for you depending on your health needs. Talk to your doctor about which option is best for your treatment plan.
- Treanda (bendamustine)
- Leukeran (chlorambucil)
- cyclophosphamide
- doxorubicin
- etoposide
- Imbruvica (ibrutinib)
- Gazyva (obinutuzumab)
- Rayos (prednisone)
- Rituxan (rituximab)
- Rituxan Hycela (rituximab/hyaluronidase)
- vincristine
- Copiktra (duvelisib)
- fludarabine
- Zydelig (idelalisib)
- Venclexta (venetoclax)
- Trexall (methotrexate)
- Azulfidine (sulfasalazine)
- Plaquenil (hydroxychloroquine)
- Xeljanz (tofacitinib)
- Orencia (abatacept)
- Humira (adalimumab)
- Enbrel (etanercept)
- Remicade (infliximab)
- Imuran (azathioprine)
Save on Budget-Friendly Truxima from Pharma Giant
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At Pharma Giant, we work with licensed pharmacies in Canada to help lower the cost of Truxima without compromising on quality. When you order Truxima from Canada through our trusted platform, you get the same medication at a much lower price, delivered straight to your door.
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How to Order Truxima Online?
- Search for Truxima, select the strength you need, and click Buy to add it to your cart. You can add other medications if needed before proceeding.
- Click Continue Checkout and enter your name, shipping address, and payment details. Use code PGSAVE10 to get 10% off your first order.
- Upload your prescription on the website, email it to info@pharmagiant.com, or fax it to 1-888-562-8159.
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Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.





