What is Verquvo?
Verquvo (vericiguat) is a prescription medication for adults with chronic heart failure.
It is used to lower the risk of death and the need for hospitalization in people who have recently been in the hospital for heart failure or needed IV (intravenous) medicines, which are given through a vein.
Verquvo is for patients whose heart pumps less than 45% of the blood it holds with each beat. This is known as “ejection fraction,” a measure of how well the heart is pumping.
It is not known if Verquvo is safe for children. Do not take Verquvo if you are pregnant or taking another medicine called a soluble guanylate cyclase (sGC) stimulator, which is a type of drug that helps blood vessels relax and widen.
How Does Verquvo Work?
Verquvo works by helping your heart and blood vessels function better. It contains vericiguat, which stimulates an enzyme called soluble guanylate cyclase (sGC).
This enzyme is important because it helps produce a molecule called cyclic guanosine monophosphate (cGMP) when it interacts with nitric oxide (NO).
cGMP helps relax blood vessels and improve heart function. In people with heart failure, the body produces less NO and sGC doesn’t work well.
Verquvo boosts the activity of sGC, increasing cGMP levels, which leads to relaxed blood vessels and better blood flow.
Dosage Information and Usage
Dosage Form and Strengths of Verquvo
- 2.5 mg tablets: Round, biconvex, white, film-coated, with “2.5” on one side and “VC” on the other side.
- 5 mg tablets: Round, biconvex, brown-red, film-coated, with “5” on one side and “VC” on the other side.
- 10 mg tablets: Round, biconvex, yellow-orange, film-coated, with “10” on one side and “VC” on the other side.
Usage
Verquvo is used to reduce the risk of cardiovascular death and the need for hospitalization in adults with chronic heart failure who have symptoms and have been recently hospitalized or needed IV diuretics.
The recommended starting dose is 2.5 mg taken orally once daily with food. The dose should be doubled approximately every 2 weeks until the target dose of 10 mg once daily is reached, based on how well the patient tolerates it.
If you can’t swallow the tablet whole, you can crush it and mix it with water before taking it.
Side Effects
Common Side Effects
- Low blood pressure (hypotension)
- Low red blood cells (anemia)
Serious but Rare Side Effects
- Severe allergic reactions (difficulty breathing, swelling of face, lips, tongue, or throat)
- Extreme dizziness or fainting
- Unusual bleeding or bruising
- Signs of infection (fever, chills, sore throat)
Warnings and Precautions
- Pregnancy and Embryo-Fetal Toxicity: Verquvo may cause harm to an unborn baby based on animal studies. Women who can become pregnant should have a pregnancy test before starting treatment. They should use effective birth control during treatment and for at least one month after the last dose to prevent pregnancy. There is a Pregnancy Surveillance Program to monitor outcomes in women exposed to Verquvo during pregnancy. It is not known if Verquvo is safe during pregnancy.
- Lactation: It is not known if Verquvo passes into human milk, but it is present in the milk of lactating rats. Due to potential risks to the baby, women should not breastfeed during treatment with Verquvo.
- Pediatric Use: The safety and effectiveness of Verquvo have not been established in children.
- Geriatric Use: No dosage adjustment is needed for elderly patients. In studies, older patients (65 years and older) did not show different safety or effectiveness compared to younger patients, but some older individuals may be more sensitive to the drug.
- Renal Impairment: No dosage adjustment is needed for patients with mild to moderate kidney problems. Verquvo has not been studied in patients with severe kidney problems or those on dialysis.
- Hepatic Impairment: No dosage adjustment is needed for patients with mild to moderate liver problems. Verquvo has not been studied in patients with severe liver problems.
Overdosage of Verquvo
Limited data exists on Verquvo overdosing in humans.
Studies tested doses up to 10 mg in heart failure patients and up to 15 mg in those with normal heart pumping (ejection fraction of 45%+). These higher doses were generally well tolerated.
Overdose symptoms may include low blood pressure (hypotension). Treatment aims to alleviate symptoms. Verquvo is unlikely to be eliminated by dialysis due to its strong protein binding in the blood.
Drug Interactions With Other Medications
- Other Soluble Guanylate Cyclase Stimulators: Verquvo should not be used with other sGC stimulators. Combining these drugs can increase the risk of side effects, including low blood pressure.
- PDE-5 Inhibitors: It is not recommended to use Verquvo with PDE-5 inhibitors, such as those used for erectile dysfunction or pulmonary hypertension. This combination can lead to a dangerous drop in blood pressure.
Alternative Medications
Here are some alternative medications to Verquvo:
- Entresto (Sacubitril/valsartan)
- Lotensin (Benazepril )
- Qbrelis
- Zestril
- Atacand (Candesartan)
- Cozaar (Losartan)
- Coreg
- Coreg CR
- Kapspargo Sprinkle
- Toprol XL
- Inspra (Eplerenone),
- Aldactone (Spironolactone)
- Invokana (Canagliflozin)
- Farxiga (Dapagliflozin)
- Jardiance (Empagliflozin)
Cost & Coupons
Your health is important, and obtaining the right medication shouldn’t be a financial burden.
At Pharma Giant, our mission is to make healthcare both affordable and accessible, ensuring that everyone has the opportunity to attain optimal health without breaking the bank.
Explore our Verquvo offerings:
- 2.5mg – 14 tablets – $106.50
- 5mg – 14 tablets – $106.50
- 10mg – 14 tablets – $213.00
In the United States, Verquvo can reach prices as high as $801.16. At Pharma Giant, we are dedicated to providing a more affordable solution, ensuring that essential medications remain within the budget for everyone.
Limited-Time Discount on Verquvo
Pharma Giant is dedicated to making healthcare more affordable without compromising on quality. For a limited time, we’re offering a special deal on Verquvo.
Use the code PGSAVE10 at checkout and enjoy an exclusive 10% discount.
This offer is valid for one-time use per customer, so make sure to take advantage of it while it lasts.
Don’t miss out on the opportunity to save on your essential medication. Experience the best in value and care with Pharma Giant today!
Savings on Bulk Purchases
Pharma Giant provides significant savings on bulk purchases, allowing you to minimize your expenses while ensuring access to medications.
Commitment to Quality and Prompt Delivery
At Pharma Giant, we are dedicated to providing top-notch medications coupled with rapid delivery services straight to your doorstep.
Our express shipping guarantees that your order will arrive within 3-5 business days anywhere in the US, ensuring that you receive your essential medications quickly and efficiently.
To protect the integrity and safety of your medication during transit, we utilize secure packaging.
Our mission is to make healthcare solutions accessible and affordable for everyone, including those without insurance coverage.
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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