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What is Votrient (pazopanib)?
Votrient is a brand name for the drug Pazopanib, which is used for the treatment of certain types of cancers, such as advanced renal cell carcinoma (a type of kidney cancer) and soft tissue sarcoma (a type of cancer that affects the body’s connective tissues). It belongs to a class of medications called tyrosine kinase inhibitors, which work by blocking the action of certain proteins that promote the growth and spread of cancer cells. Votrient is typically prescribed by a doctor and is available in tablet form.
What are the Indications for Votrient?
Votrient is indicated for the treatment of several types of cancer, including advanced renal cell carcinoma (kidney cancer) and soft tissue sarcoma, a type of cancer that forms in soft tissues like muscles or tendons.
How is Votrient used?
Votrient should be stored at room temperature between 68° – 77°F(20° – 25°) in its original container, away from light and moisture.
Keep out of reach of children and pets.
Votrient should be taken once per day with or without food, at the same time every day to maintain a consistent level of medication in your body. Swallow the tablets whole with a glass of water. Do not crush, chew, or break the tablets.
Votrient is available in tablet form in the strength of 200 mg.
The recommended dose is 800 mg or three tablets once per day.
It’s important to understand that although Votrient is FDA-approved, it comes with side effects that may or may not affect you.
Before starting Votrient, you should discuss possible side effects with your doctor or pharmacist.
Common Side Effects
Not all side effects require medical attention. As your body adjusts to Votrient, side effects may go away.
Tell your doctor if you experience the following symptoms, and they become severe or do not go away on their own:
- Feeling tired or fatigue
- Loss of appetite
- Stomach pain
- High blood pressure
- Abnormal liver function
Serious Side Effects
Severe adverse reactions while using Votrient can occur. Seek emergency medical care or call 911 if you experience any of the following symptoms:
- Severe allergic reaction: severe rash or itching, swelling in the face, lips, tongue, or throat, rapid heartbeat, fainting or dizziness, or problems breathing or swallowing.
- Bleeding: unusual bleeding including nosebleeds, bleeding gums, or blood in urine or stool.
- Blood clots: swelling, pain, or redness in the arm or leg, chest pain, or shortness of breath.
- Heart problems: shortness of breath, chest pain, or fainting that could lead to heart attack or heart failure.
The information above does not list all possible side effects. Contact your doctor or pharmacist if you experience any side effects not listed. You or your doctor may report side effects to the FDA by calling 1-800-FDA-1088.
Warnings & Precautions
Before using Votrient, tell your doctor or pharmacist:
- If you are allergic to any medications such as pazopanib
- If you have a history of high blood pressure
- If you have kidney problems
- If you have liver problems
- If you have a thyroid disorder
- If you have had surgery recently
- If you are pregnant or expect to become pregnant
- If you are breastfeeding or plan to breastfeed
Taking Votrient may result in unusual or excessive bleeding. If you experience unusual bleeding, such as nosebleeds, bleeding gums, or blood in the urine or stool, contact your doctor immediately.
Votrient may cause hypothyroidism, which is a condition where the thyroid gland does not produce enough hormones. Signs of hypothyroidism include fatigue, weight gain, cold intolerance, and constipation. If you experience any of these symptoms, contact your doctor.
Votrient may cause lung problems, including interstitial lung disease, which can be life-threatening. Symptoms of interstitial lung disease include coughing, shortness of breath, and chest pain. If you experience any of these symptoms, seek medical attention immediately.
Votrient may cause liver problems, including hepatitis, liver failure, and liver damage. Signs of liver problems include yellowing of the skin or eyes, dark urine, abdominal pain, and nausea. If you experience any of these symptoms, contact your doctor immediately.
High blood pressure
Votrient can sometimes cause high blood pressure. This can lead to health problems like heart attacks, strokes, and kidney damage. Your doctor will monitor your blood pressure regularly while you are taking it and may prescribe medication to help lower it if needed.
Taking Votrient may cause heart problems, such as heart failure or a heart attack. If you experience symptoms such as chest pain, shortness of breath, or fainting, seek medical attention immediately.
Votrient may increase the risk of blood clots, which can be life-threatening. Signs of a blood clot include swelling, pain, or redness in the arm or leg, chest pain, or shortness of breath. Seek medical attention right away if you experience any of these symptoms.
Votrient may cause proteinuria, which is a condition where protein is present in the urine. Signs of proteinuria include foamy or frothy urine. If you experience these symptoms, contact your doctor.
GI perforation and fistula
Votrient can sometimes cause a serious condition called GI perforation and fistula which can be life-threatening. This happens when a hole or abnormal passage forms in the gastrointestinal (GI) tract, which can cause symptoms like severe stomach pain, nausea, and vomiting. Your doctor will monitor you closely while you are taking it and may perform regular tests to check for signs of this condition. If you experience symptoms like severe stomach pain or vomiting, contact your doctor right away.
Tumor Lysis syndrome
Votrient can sometimes cause a condition called tumor lysis syndrome. This happens when cancer cells break down quickly and release harmful substances into the body. It can cause problems like kidney damage, heart problems, and abnormal blood tests. Your doctor will monitor you closely and may give you medications to help prevent this from happening. If you experience symptoms like weakness, nausea, or swelling, contact your doctor right away.
Votrient can weaken the body’s immune system, making it harder to fight off infections. This means that people taking Votrient may be more susceptible to infections like colds, the flu, or other illnesses. It is important to practice good hygiene, such as washing your hands regularly, avoiding contact with sick people, and getting vaccinated, to reduce the risk of infection. If you develop symptoms of an infection, such as fever or cough, contact your doctor right away.
Votrient can affect fertility for men and women. If you are trying to conceive or plan to conceive, consult with your doctor before taking.
Pregnant or Planning to Become Pregnant
Votrient during pregnancy can severely harm your unborn child. It is recommended to use effective contraceptive. If you are pregnant or become pregnant while taking it, contact your doctor immediately.
It is not known if this medication passes into breast milk however it is not recommended to take it while breastfeeding. If you are breastfeeding or considering breastfeeding while taking Votrient, talk to your doctor for the best course of action before taking it.
Interactions & Contraindications
Before using Votrient, tell your doctor or pharmacist if you take any medications, herbal supplements, or vitamins.
Taking Votrient while consuming grapefruit or grapefruit juice can increase the potency. This effect can lead to an increase of side effects.
Taking it with blood thinners, such as warfarin, can increase the risk of bleeding. Blood thinners work by slowing down the blood’s ability to clot, which can be helpful in some situations. However, taking Votrient with a blood thinner can further increase this effect, which can lead to serious bleeding problems. Consult with your doctor to determine if a change of therapy is needed.
Taking Votrient with antacids can decrease the effectiveness. Antacids work by reducing stomach acid levels, which can affect how well it is absorbed by the body. If you need to take an antacid while on Votrient, your doctor may recommend that you take it at least 2 hours before or 2 hours after taking it to minimize the interaction.