What is Wezlana?
Wezlana is a prescription treatment that helps control certain long-term immune system conditions.
Wezlana is used for plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis. These conditions happen when the immune system attacks healthy parts of the body by mistake.
Wezlana is given by injection using a Wezlana prefilled syringe.
Indications and Benefits of Wezlana
Wezlana is approved for adults and children age six and older with moderate to severe plaque psoriasis and active psoriatic arthritis. It is also approved for adults with Crohn’s disease and ulcerative colitis that are moderate to severe symptoms.
These conditions cause long-term swelling, pain, skin problems, and digestive issues.
Wezlana helps by blocking two immune proteins called IL-12 and IL-23. These proteins trigger inflammation in the body. By reducing this reaction, Wezlana helps improve skin, joint movement, and gut health.
The Wezlana dosing schedule is spaced out, which means fewer injections over time.
What Are the Benefits of Wezlana?
- This treatment helps clear red, thick, and scaly skin caused by plaque psoriasis.
- It reduces joint pain, stiffness, and swelling in people with psoriatic arthritis.
- Many users notice less stomach pain, diarrhea, and tiredness linked to Crohn’s disease.
- Bowel symptoms in ulcerative colitis become easier to manage over time.
- The action works by blocking IL-12 and IL-23, which are immune proteins that cause inflammation.
- The injection is given under the skin, which is known as the route of administration.
- The dosing schedule is simple, with fewer injections than many other options.
- Daily comfort, sleep, and movement often improve for people with immune conditions.
- Flare-ups may happen less often as the immune system stays more balanced.
- A prefilled syringe is used for safe and easy handling.
Fact Table
| Fact Category | Fact Details |
| Generic Name | Ustekinumab-auub |
| Wezlana Class | A monoclonal antibody that blocks immune system proteins |
| Primary Use | Treatment of plaque psoriasis, psoriatic arthritis, Crohn’s disease, and ulcerative colitis |
| Additional Benefit | Helps lower long term inflammation and improve symptoms |
| Available Form | Prefilled syringe and intravenous formulation |
| Method of Administration | Injection under the skin or into a vein |
| Frequency | Given on a scheduled dosing plan set by a healthcare provider |
| Storage Instructions | Store in a refrigerator, do not freeze, protect from light |
| Pregnancy and Breastfeeding | Limited human data; consult a doctor before use |
| Drug Interactions | Live vaccines should be avoided |
| Manufacturer | Biosimilar to Stelara, approved by the US FDA in 2023 |
How It Works
This treatment works by calming an overactive immune system. In some conditions, the immune system sends out strong signals that cause swelling, pain, skin problems, and bowel issues.
Two of these signals are called IL 12 and IL 23. They tell the body to create inflammation.
This treatment blocks those signals, which helps reduce redness, pain, and tissue damage. By lowering inflammation, the body can heal better, and symptoms become easier to manage over time.
Dosage
The dose is based on body weight, age, and the health condition being treated. It is given by injection under the skin or by infusion into a vein.
For skin and joint conditions, the dose usually starts at Week 0 and Week 4, then continues every 12 weeks.
For Crohn’s disease and ulcerative colitis, treatment begins with an intravenous dose, followed by regular injections every 8 weeks.
A healthcare provider decides the correct amount using the current body weight.
What Dosage Strengths Does Wezlana Come In?
- 45 mg per 0.5 mL prefilled syringe
- 90 mg per mL prefilled syringe
- 45 mg per 0.5 mL single-dose vial
- 130 mg per 26 mL intravenous vial
Dosage Chart
| Condition | Age Group | Body Weight | Dose | Schedule | Method |
| Plaque Psoriasis | Adult | 100 kg or less | 45 mg | Week 0, Week 4, then every 12 weeks | Injection under the skin |
| Plaque Psoriasis | Adult | More than 100 kg | 90 mg | Week 0, Week 4, then every 12 weeks | Injection under the skin |
| Plaque Psoriasis | Pediatric 6+ | Less than 60 kg | 0.75 mg per kg | Week 0, Week 4, then every 12 weeks | Injection under the skin |
| Plaque Psoriasis | Pediatric 6+ | 60 to 100 kg | 45 mg | Week 0, Week 4, then every 12 weeks | Injection under the skin |
| Plaque Psoriasis | Pediatric 6+ | More than 100 kg | 90 mg | Week 0, Week 4, then every 12 weeks | Injection under the skin |
| Psoriatic Arthritis | Adult | All weights | 45 mg | Week 0, Week 4, then every 12 weeks | Injection under the skin |
| Psoriatic Arthritis with severe plaque psoriasis | Adult | More than 100 kg | 90 mg | Week 0, Week 4, then every 12 weeks | Injection under the skin |
| Psoriatic Arthritis | Pediatric 6+ | Less than 60 kg | 0.75 mg per kg | Week 0, Week 4, then every 12 weeks | Injection under the skin |
| Psoriatic Arthritis | Pediatric 6+ | 60 kg or more | 45 mg | Week 0, Week 4, then every 12 weeks | Injection under the skin |
| Crohn Disease | Adult | 55 kg or less | 260 mg | One-time dose | Infusion into a vein |
| Crohn Disease | Adult | 56 to 85 kg | 390 mg | One-time dose | Infusion into a vein |
| Crohn Disease | Adult | More than 85 kg | 520 mg | One-time dose | Infusion into a vein |
| Ulcerative Colitis | Adult | 55 kg or less | 260 mg | One-time dose | Infusion into a vein |
| Ulcerative Colitis | Adult | 56 to 85 kg | 390 mg | One-time dose | Infusion into a vein |
| Ulcerative Colitis | Adult | More than 85 kg | 520 mg | One-time dose | Infusion into a vein |
| Crohn’s Disease and Ulcerative Colitis | Adult | All weights | 90 mg | Every 8 weeks after an IV dose | Injection under the skin |
Usage Guide
This treatment must be used exactly as directed by your doctor. The correct dose, timing, and method depend on the health condition, body weight, and age.
Some people receive the first dose through a vein at a clinic, while others use injections under the skin at home after proper training.
Follow-up visits are important to check progress and safety.
How do you use Wezlana?
- Always follow the exact instructions given by a healthcare provider.
- Attend all scheduled follow-up visits for safety checks.
- The first dose for Crohn’s disease and ulcerative colitis is given through a vein at a clinic.
- Later doses for Crohn’s disease and ulcerative colitis are given as injections under the skin.
- People with plaque psoriasis or psoriatic arthritis receive injections under the skin from the start.
- Children should receive injections from a trained healthcare provider.
- Adults or caregivers may give injections at home after proper training.
- Injections can be given in the upper arms, thighs, stomach area, or buttocks.
- Avoid areas that are red, bruised, sore, or hard.
- Use a different injection site each time.
- Let the solution reach room temperature before use.
- Never reuse syringes, needles, or vials.
- Throw away any unused product after one use.
Side Effects
Side effects can happen with this treatment because it affects how the immune system works. Some Wezlana side effects are mild, while others can be serious and need quick care.
The route of administration, such as injection under the skin using a Wezlana prefilled syringe or infusion into a vein, can also cause local reactions.
It is important to follow Wezlana’s prescribing information and report any unusual symptoms to a medical practitioner.
Common Side Effects
- Runny nose, sore throat, or blocked nose
- Upper respiratory infections
- Fever
- Headache
- Feeling tired
- Itching
- Nausea or vomiting
- Flu-like symptoms
- Redness at the injection site
- Vaginal yeast infections
- Urinary tract infections
- Sinus infection
- Bronchitis
- Diarrhea
- Stomach pain
- Joint pain
Severe Side Effects
- Serious allergic reactions, including swelling ofthe face, eyelids, tongue, or throat
- Feeling faint or chest tightness from an allergic reaction
- Severe skin rash
- Posterior Reversible Encephalopathy Syndrome (PRES) causes headache, seizures, confusion, or vision problems
- Lung inflammation causing shortness of breath or a persistent cough
- Serious infections that may require hospitalization
- Signs of tuberculosis (TB) or other bacterial, fungal, or viral infections
- Increased risk of certain types of cancer
Missed Dose
If a scheduled dose is missed, take it as soon as possible if it is close to the normal dosing time. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule.
Do not give two doses at the same time. Always follow the Wezlana dosing schedule and the instructions from your doctor to stay safe and maintain effectiveness.
Overdose
Taking too much may increase the risk of side effects. In clinical trials, high doses have been used safely, but any signs of unusual reactions should be reported immediately.
Storage Information
Store vials and Wezlana prefilled syringes in a refrigerator between thirty six and forty six degrees Fahrenheit or two and eight degrees Celsius. Keep them in the original carton to protect them from light.
Do not freeze or shake. If needed, some prefilled syringes and forty-five milligram vials may be kept at room temperature up to eighty six degrees Fahrenheit or thirty degrees Celsius for a maximum of thirty days, and the date should be recorded.
Warnings
This treatment affects the immune system and may increase the risk of serious infections and other health problems.
It is important to follow Wezlana’s prescribing information and contact your doctor if unusual symptoms occur. People often search for Wezlana side effects and Wezlana route of administration to understand how to use it safely.
Careful monitoring is needed for patients with chronic infections, a history of tuberculosis, or past immune system problems.
- Using Wezlana may increase the risk of serious infections, including bacterial, fungal, or viral infections.
- Avoid starting treatment if there is an active infection until it is resolved or treated.
- People with latent tuberculosis should be treated before using Wezlana, and monitoring for tuberculosis symptoms is required.
- Individuals with genetic problems affecting IL-12 and IL-23 may be at higher risk for serious infections.
- Malignancies, including skin cancers, have been reported during treatment, especially in patients with previous risk factors.
- Severe allergic reactions, including swelling of the face, tongue, or throat, may occur and need immediate medical care.
- Posterior Reversible Encephalopathy Syndrome, a rare brain condition causing headaches, seizures, confusion, or vision problems, has been reported.
- Lung inflammation and noninfectious pneumonia may develop, causing cough, shortness of breath, or hospitalization.
- Live vaccines should be avoided during treatment and for one year after stopping Wezlana.
- Non-live vaccines may not work effectively while using Wezlana.
Boxed Warning and Precautions for Wezlana
| Wezlana is an immunosuppressive treatment, which means it lowers the activity of the immune system. This can increase the chance of serious infections and certain types of cancer. Patients should be carefully evaluated before starting therapy and monitored during treatment. Live vaccines must not be given during treatment, and all age-appropriate vaccines should be completed beforehand. Hypersensitivity reactions, including severe allergic responses, can occur and require stopping the treatment immediately. Special caution is advised for patients with a history of recurrent infections, tuberculosis, or previous malignancy. |
Contraindications
Wezlana should not be used in people who are allergic to ustekinumab or any of the ingredients in the product.
Serious allergic reactions, including anaphylaxis and swelling of the face, tongue, or throat, have been reported with ustekinumab products. It is important to tell your doctor about any history of allergies before starting treatment.
Follow Wezlana’s prescribing information to stay safe.
Interactions
- Immunosuppressive treatments (safety not fully studied)
- Phototherapy (safety not fully studied)
- Methotrexate (MTX) in psoriatic arthritis (no change in safety or effectiveness)
- Immunomodulators such as 6-mercaptopurine (6-MP)
- Azathioprine (AZA)
- Corticosteroids
- Drugs metabolized by CYP450 enzymes (monitor effect or concentration)
- Allergen immunotherapy (may reduce protective effect and increase risk of allergic reactions)
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