What is Xolair (Omalizumab)?
Xolair is a subcutaneous (under-the-skin) injectable medication used for treating and managing moderate to severe allergic asthma in adults and children aged six and older, chronic idiopathic urticaria in adults and children aged twelve and older, and nasal polyps in adults who are eighteen years of age and older.
How does Xolair Work?
Xolair is a monoclonal antibody that targets IgE. It binds to circulating IgE, preventing it from attaching to mast cells and basophils. This prevents the release of histamine, which causes inflammation within the body. Histamine is also known to cause symptoms such as a runny nose, watery eyes, tissue swelling, itchy skin, and hives.
Usage
Storage
Xolair should be stored in the refrigerator between 36F to 46F (2C to 8C).
How to Take
Xolair comes in a prefilled syringe that is injected subcutaneously (under the skin). Xolair should be refrigerated until the time of use. If Xolair is left at room temperature for longer than two days, it should be discarded. Depending on your doctor’s recommendation, Xolair is usually given every 2 or 4 weeks. Xolair should be injected into the stomach, thigh, or upper arm. The prefilled syringe contains a single dose of Xolair and should be discarded into a sharps container once injected.
Dosage
Xolair prefilled syringes are available in 75mg and 150mg doses.
Dosing for Adults and Children
Asthma
The recommended dose of Xolair for treating moderate to severe asthma in adults and children aged six and older is 150-375mg every 2-4 weeks. Your total IgE level and body weight determine the dosage and frequency.
Chronic Idiopathic Urticaria
The recommended dose of Xolair for treating chronic idiopathic urticaria in adults and children aged 12 and older is 150-300mg every four weeks. The dosage is not dependent on IgE level or body weight but is determined by your doctor.
Nasal Polyps
The recommended dose of Xolair for the treatment of nasal polyps in adults aged 18 and older is 75-600mg every 2-4 weeks. The total IgE level and body weight determine the dosage and frequency.
Missed Dose
If you miss a dose of Xolair, call your doctor for further instructions and a new dosing schedule.
Overdose
Taking too much Xolair can lead to serious side effects. If you suspect an overdose, seek emergency medical attention or call the poison control helpline at 1-800-222-1222.
Side Effects of Medication
If you experience signs and symptoms of an allergic reaction, such as hives, rash, itching, difficulty breathing, or swelling of the face, mouth, or throat, seek medical attention immediately.
The most common side effects of Xolair include:
- Rash
- Fever
- Nosebleeds
- Joint pain or bone fractures
- Arm and leg pain
- Nausea, vomiting, diarrhea, and stomach pain
- Headache
- Dizziness
- Fatigue
- Ear infection or ear pain
- Pain, bruising or swelling at the injection site
- Cold symptoms such as stuffy nose, sneezing, sinus pain, cough, and sore throat
Some serious side effects can also occur. Call your doctor or seek immediate medical attention if you experience any of the following symptoms:
- Ongoing nausea, vomiting, severe or watery diarrhea
- Difficulty breathing
- Numbness or tingling in the arms and legs
- Fever, muscle pain, and rash within a few days of injection
- Fever, ear pain or full feeling, trouble hearing, or ear drainage (signs of an ear infection)
- Chest pain or pressure, jaw or shoulder pain (signs of a heart attack)
- Sudden numbness or weakness, problems with vision or speech, coughing up blood, swelling or redness in an arm or leg (signs of a blood clot)
Warnings and Precautions
Xolair is contraindicated in those who have a known allergy or sensitivity to Xolair or any of its ingredients.
Children
Xolair is approved for treating moderate to severe asthma in children aged six and older and treating chronic idiopathic urticaria in children aged twelve and older.
Pregnancy
It is not known if Xolair is safe during pregnancy as IgE crosses the placenta and there may be a potential harm to the fetus. Uncontrolled asthma in pregnancy is associated with preeclampsia, prematurity, and low birth weight. Xolair can be used in pregnancy under a doctor’s supervision if the benefit outweighs the risk.
Lactation
Xolair is approved for use in women who are breastfeeding. Studies have shown that there have been no adverse effects on breastfed infants.
Cancers
Patients taking Xolair exhibited a higher rate of cancer during observational studies. The cancers reported include breast cancer, non-melanoma skin, prostate, melanoma, and parotid gland. It is unknown if more prolonged exposure to Xolair results in a higher risk of cancer development. Speaking to your doctor about your cancer risk before starting Xolair is essential.
Acute Asthma
Xolair has not been shown to alleviate acute asthma exacerbations. Do not use Xolair for the treatment of acute attacks or acute bronchospasm.
Corticosteroid Use
Do not abruptly discontinue systemic or inhaled corticosteroids upon initiation of Xolair for asthma. Corticosteroids should be decreased gradually under the supervision of a doctor.
Eosinophilic Conditions
Some patients taking Xolair presented with severe systemic eosinophilia. Patients taking Xolair should be monitored for eosinophilia intermittently while receiving treatment.
Fever, Rash, and Arthralgia
Some patients taking Xolair experienced arthritis/arthralgia, rash, fever, and lymphadenopathy. Patients exhibiting these symptoms should have Xolair discontinued.
Parasitic Infection
Patients at high risk of parasitic infection should be monitored throughout treatment with Xolair for active infection. Studies have shown an increased risk of parasitic infections while taking Xolair. Patients who develop symptoms of parasitic infection should be evaluated appropriately.
Laboratory Tests
Patients taking Xolair showed an elevated serum total IgE level after one year of use.
Drug Interactions
This is not a complete list of potential drug interactions. Before taking Xolair, tell your doctor if you take any medications, herbal supplements, or vitamins.
Efgartigimod alfa
Efgartigimod alfa, a medication used in the treatment of generalized myasthenia gravis, may reduce the blood levels and effects of Xolair.
Omacetaxine
Omacetaxine, a medication used in treating chronic myelogenous leukemia, may increase the risk of serious infections when used with Xolair.
Alternative Medications
Other drugs are available to treat asthma, chronic idiopathic urticaria, and nasal polyps. Speak to your doctor to discuss other medications.
Corticosteroids
Corticosteroids reduce inflammation, swelling, and mucous production in the airways of people with asthma. Available corticosteroids include prednisone and methylprednisone (Medrol)
Leukotriene Modifiers
Leukotriene modifiers work by blocking leukotrienes, reducing breathing problems in people with asthma. Available leukotriene modifiers include montelukast (Singulair), zafirlukast (Accolate), and zileuton (Zyflo)
Biologic Medications
Biologic medications work by inhibiting the overactive signaling of IL-4 and IL-13. These proteins contribute to the inflammation that causes moderate-to-severe asthma. Available biologic medications include mepolizumab (Nucala), benralizumab (Fasenra), reslizumab (Cinqair), and dupilumab (Dupixent).
Buy Xolair: Medication Cost & Coupons
For those looking to buy Xolair, significant cost savings can be realized. The cost of prescription medications can be a significant burden, especially in the United States where prices are often high. A prime example of this is the drug Xolair. In the U.S., the cost for Xolair, particularly the 150mg dosage with 1 injection, can exceed $999 for individuals without insurance coverage. This high price point can make it challenging for many patients to access the medication they need.
However, there is a cost-effective solution available through Pharma Giant (PG). By obtaining a prescription from a doctor, Americans can order Xolair online securely and conveniently from a licensed & trusted Canadian pharmacy through PG. At Pharma Giant, the price for Xolair is significantly lower, available starting at $999.00 per 150mg injection. This presents a substantial saving opportunity for those requiring this medication.
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One of the key aspects of this service is the expedited shipping process. Once an order is placed, the drugs are express shipped to the United States, typically arriving within 3-5 business days. This quick turnaround time ensures that patients receive their order promptly, minimizing any potential disruption to their treatment plans.
Xolair Coupon Offer
To make this deal even more attractive, PG offers a special discount for first-time customers. By using the coupon code PGSAVE10, new customers can save 10% on their first order. This additional discount further lowers the financial barrier, making essential medications like Xolair more accessible to those in need.
By choosing to order through Pharma Giant, patients in the U.S. can manage their health effectively while also making significant savings on their medication costs.
| Strength | Quantity | Total Price | Price per Injection |
|---|---|---|---|
| 150mg | 1 injection | $999.00 | $999.00 |
| 150mg | 2 injections | $1,900.00 | $950.00 |
| 150mg | 3 injections | $2,700.00 | $900.00 |
Frequently Asked Questions
Disclaimer
Pharma Giant provides medical information to help you better understand medications and medical conditions.This content is for informational use only and does not replace advice from a licensed medical practitioner. Consult your doctor or pharmacist before starting or changing any medication. All our partners follow strict safety standards set by their country’s health authorities to make sure you receive safe and high-quality medications.
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