Wegovy, a brand name for the drug semaglutide, is a groundbreaking medication designed for weight management and obesity treatment. Approved by the FDA in June 2021, Wegovy has shown significant results in clinical trials, helping patients lose an average of 12.4% of their body weight. With obesity affecting approximately 70% of adults in the US, the demand for effective weight loss solutions like Wegovy is increasing.

As more people turn to Wegovy to aid in their weight loss journey, understanding its interactions with alcohol becomes vital. Alcohol consumption is prevalent, with over 60% of American adults reporting regular drinking habits. Combining Wegovy with alcohol raises important questions about safety and efficacy.

This article explores the potential risks, safety considerations, and practical tips for alcohol and Wegovy. We aim to provide a comprehensive guide for anyone considering or currently using Wegovy, ensuring they can make informed decisions about their health and lifestyle.

Key Findings

  • It is generally safe to drink alcohol in moderation while taking Wegovy, but caution is necessary to avoid potential side effects and interactions.
  • Combining alcohol with Wegovy can intensify gastrointestinal side effects like nausea, vomiting, diarrhea, and abdominal pain due to increased gastric acid secretion and delayed gastric emptying.
  • Both Wegovy and alcohol are metabolized in the liver, potentially increasing liver stress and risk of liver damage when consumed together.
  • Combining Wegovy and alcohol can lead to increased sedation, dizziness, lightheadedness, and mood changes, affecting overall safety and mental health.
  • To minimize risks, limit alcohol consumption, stay hydrated, eat before drinking, monitor blood sugar levels, and seek medical advice if experiencing significant side effects.
  • Insights from Reddit users indicate varied reactions to alcohol while on Wegovy, with some experiencing severe side effects and others losing their desire for alcohol altogether.

Can You Drink Alcohol on Wegovy?

What are the Potential Side Effects of Wegovy and Alcohol Use

Yes, you can drink alcohol while on Wegovy, but with caution. Drinking alcohol in moderation is generally considered safe for most people taking Wegovy. This means adhering to recommended limits. There is no direct contraindication between Wegovy and alcohol in the prescribing information, meaning there is no explicit medical rule against consuming alcohol while on this medication.

However, caution is necessary due to several reasons. For more detailed information, explore the potential side effects of drinking alcohol while on Wegovy.

What are the Potential Side Effects of Wegovy and Alcohol Use?

Combining alcohol with Wegovy can lead to various side effects due to the interactions between the two substances. Here’s a detailed look at the potential side effects:

Gastrointestinal Issues

The main gastrointestinal side effects associated with Wegovy include nausea, vomiting, diarrhea, constipation, and abdominal pain. These issues can be intensified by alcohol consumption for several reasons:

Increased Gastric Acid Secretion

Alcohol stimulates the stomach to produce more gastric acid. This increase in acid can irritate the stomach lining, potentially worsening Wegovy symptoms like diarrhea and abdominal pain.

Alcoholic beverages affect gastric acid secretion and gastrin release differently based on their ethanol content. Experts found that beer and wine are strong stimulants of gastric acid secretion. The effect of beer on acid secretion is comparable to the maximal acid output. In contrast, beverages with higher ethanol content, such as whisky, gin, and cognac, do not stimulate gastric acid secretion.

Delayed Gastric Emptying

Wegovy works partly by slowing down the rate at which the stomach empties its contents into the small intestine. Alcohol can further delay gastric emptying, leading to a greater feeling of fullness, discomfort, and potentially more severe nausea and vomiting.

High alcohol concentrations (above 15%), in particular, are found to inhibit gastric motility. On the other hand, beverages with low alcohol concentrations, like wine and beer, tend to accelerate gastric emptying.


Alcohol is a diuretic, which means it increases urine production and can lead to dehydration. Dehydration can worsen symptoms of constipation and abdominal pain, both of which are potential side effects of Wegovy.

Interaction with Medication Metabolism

Alcohol can affect the metabolism of medications in the liver. Although specific interactions between Wegovy and alcohol are not well-documented, changes in drug metabolism could potentially alter the effectiveness and side effect profile of Wegovy, leading to unpredictable gastrointestinal symptoms.

Blood Sugar Fluctuations

Consuming alcohol while on Wegovy can increase the risk of hypoglycemia since alcohol can cause blood sugar levels to drop. This happens because alcohol inhibits the liver’s ability to produce glucose, a process known as gluconeogenesis. When the liver is busy metabolizing alcohol, it can’t release as much glucose into the bloodstream, leading to hypoglycemia (low blood sugar).

At the same time, certain alcoholic drinks, especially those with high sugar content (like cocktails or sweet wines), can cause a rapid increase in blood sugar levels. This is due to the sugar in these drinks being rapidly absorbed into the bloodstream.

Liver Stress

The liver is the primary organ responsible for metabolizing alcohol. When alcohol is consumed, the liver breaks it down through a series of processes. This can generate toxic byproducts like acetaldehyde, which can damage liver cells and lead to inflammation and scarring over time. Both Wegovy and alcohol are metabolized in the liver. When taken together, they can increase the liver’s workload, potentially leading to liver stress or damage.

Central Nervous System (CNS) Effects

Drinking alcohol while taking Wegovy can have various CNS effects, potentially complicating both the efficacy and safety of the medication. Here are the key CNS effects to be aware of:

Increased Sedation and Drowsiness

Both alcohol and Wegovy have sedative properties. Alcohol acts as a CNS depressant, slowing down brain function and neural activity, leading to drowsiness and sedation. Wegovy can also cause fatigue and tiredness in some individuals. When taken together, the sedative effects of both substances can compound, resulting in increased drowsiness and sedation. This can impair cognitive and motor functions, making activities such as driving or operating heavy machinery dangerous.

Dizziness and Lightheadedness

Alcohol can cause vasodilation (widening of blood vessels), leading to a drop in blood pressure, which can cause dizziness and lightheadedness. Wegovy can also cause similar symptoms as a side effect. When combined, these effects can be more pronounced, increasing the risk of fainting or losing balance. This is particularly concerning for older adults, who are more prone to falls and related injuries.

Mood Changes

Alcohol is known to alter neurotransmitter levels in the brain, affecting mood regulation. It can cause or exacerbate feelings of depression, anxiety, or irritability.

Wegovy is also associated with anxiety, depression, and suicidal thoughts. According to the prescribing information and clinical trial data, some patients on Wegovy have reported these adverse effects. While these are relatively rare, they can occur.

Combining alcohol and Wegovy can lead to unpredictable mood swings, heightened anxiety, or depressive symptoms. This can negatively affect overall mental health and well-being, potentially leading to more serious mental health issues if not managed properly.

Cardiovascular Effects

When drinking alcohol while on Wegovy, there are several potential cardiovascular effects that could arise. These include:

Increased Heart Rate (Tachycardia)

Both alcohol and Wegovy can independently increase heart rate. Clinical trials showed mean increases of 1 to 4 beats per minute (bpm) in Wegovy-treated adults compared to placebo. In pediatric patients with normal baseline heart rates, 54% on Wegovy had increases of 20 bpm or more, compared to 39% on placebo.

Alcohol, on the other hand, can stimulate the sympathetic nervous system, leading to an increased heart rate. Experts discovered that drinking a 12-ounce beer, a 5-ounce glass of wine, or a cocktail with 1.5 ounces of liquor typically raised participants’ heart rates by about five bpm within six hours. When consuming two or more drinks, the heart rate increase was more pronounced, and the elevated heart rate persisted for up to 24 hours.

When Wegovy and alcohol are combined, the effects might be additive or synergistic, leading to significant increases in heart rate.

High Blood Pressure (Hypertension)

Alcohol consumption can cause transient increases in blood pressure due to vasoconstriction and increased cardiac output. A recent study examined the effects of medium-dose and high-dose alcohol consumption on blood pressure over different time periods.

For medium-dose alcohol (14 to 28 grams), systolic and diastolic blood pressure (SBP and DBP) decreased within 6 hours, with no effects from 7 to 12 hours, and still no effects after 13 hours. For high-dose alcohol (over 30 grams), SBP and DBP decreased within 6 hours, decreased again from 7 to 12 hours, but increased after 13 hours.

Generally, a decrease in SBP and DBP can be beneficial for people with high blood pressure, as it reduces the strain on the heart and arteries. However, an increase in these measures, as seen with high-dose alcohol consumption after 13 hours, can be harmful, potentially leading to hypertension and associated cardiovascular risks.

Wegovy itself is not commonly associated with causing hypertension, but it can lead to increased heart rate in some individuals. The interaction between alcohol and Wegovy might compound these cardiovascular effects.

Irregular Heartbeats (Arrhythmias)

Alcohol is known to cause arrhythmias, such as atrial fibrillation. The mechanisms include electrolyte imbalances and direct effects on cardiac cells. Wegovy’s impact on heart rate and potential interaction with alcohol could exacerbate the risk of arrhythmias.

Tips for Drinking Alcohol While on Wegovy

Tips for Drinking Alcohol While on Wegovy

Managing side effects due to drinking alcohol while on Wegovy involves several strategies to mitigate discomfort and reduce potential health risks. Here are some recommendations:

Limit Alcohol Consumption

Moderation is key when it comes to alcohol consumption, particularly for those on medication. Women should aim to drink no more than one drink per day, while men can consume up to two drinks per day. One drink is equal to either 12-ounce beer, a 5-ounce glass of wine, or a cocktail with 1.5 ounces of liquor. Additionally, incorporating alcohol-free days into your routine can be beneficial, giving your body a chance to recover and minimizing the potential impact on your medication.

How To Control Alcohol Consumption

Learning how to control drinking alcohol can be challenging, but with the right strategies and support, it is achievable. Here are some tips to help you manage and reduce your alcohol intake:

  • Set Clear Goals: Decide how many days a week you want to drink and how many drinks you’ll have on those days. Use a journal or an app to keep track of your drinking habits.
  • Understand Your Triggers: Recognize the times, places, and emotions that trigger your drinking. Find other activities or coping mechanisms to replace drinking during these times.
  • Choose Non-Alcoholic Alternatives: Enjoy non-alcoholic beverages that mimic your favorite cocktails. Drink plenty of water or other non-alcoholic drinks to stay hydrated and reduce the urge to drink alcohol.
  • Practice Mindfulness and Stress Management: Engage in meditation, deep breathing exercises, or yoga to reduce stress and the urge to drink. Pursue activities that keep you occupied and distracted from the desire to drink.
  • Seek Support: Share your goals with a friend or family member who can support you. Consider joining groups like Alcoholics Anonymous (AA) or other local support groups.
  • Create a Healthy Routine: Engage in physical activities that can help reduce stress and improve your overall well-being. Maintain a healthy diet to keep your body nourished and reduce cravings for alcohol.
  • Avoid High-Risk Situations: Avoid places and situations where heavy drinking is common. If you’re going to a social event, plan how you’ll handle situations where alcohol is present.
  • Educate Yourself: Understand the health risks associated with excessive alcohol consumption. Keep up with information on how to reduce alcohol intake and its benefits.
  • Set Up Rewards: Set up a reward system for reaching your goals, such as treating yourself to something special for achieving milestones.
  • Consider Professional Help: If you find it difficult to control your drinking on your own, seek help from a therapist or counselor who specializes in addiction. Consult with a healthcare provider who can offer medical advice and potential treatments for reducing alcohol consumption.

Reducing alcohol intake can significantly improve your health, relationships, and overall quality of life.

Stay Hydrated

It is important to drink plenty of water before, during, and after drinking to help stay hydrated and potentially reduce the severity of side effects such as dehydration and headaches. Additionally, consider incorporating electrolyte drinks into your routine to help maintain a balance of essential minerals in your body.

Eat Before Drinking

Eating a balanced meal before drinking alcohol can help slow its absorption and reduce its impact on your blood sugar levels. Additionally, opting for healthy snacks while drinking can further aid in keeping your blood sugar stable, promoting overall well-being and minimizing potential negative effects.

Best Foods to Eat Before Drinking Alcohol

Here are some of the best foods to eat before drinking alcohol:

  • Complex Carbohydrates: Whole grains such as brown rice, quinoa, and whole-wheat bread are excellent options to consume before drinking alcohol. These complex carbohydrates provide sustained energy and help slow down the absorption of alcohol in your bloodstream. Additionally, oats are high in fiber and can stabilize blood sugar levels.
  • Healthy Fats: Incorporating healthy fats into your pre-drinking meal can significantly impact how your body processes alcohol. Avocados are rich in healthy fats. Similarly, nuts and seeds like almonds, walnuts, and chia seeds provide a good mix of healthy fats and protein, which can protect your stomach lining and slow down the digestion process.
  • Proteins: Lean meats such as chicken, turkey, and fish are excellent sources of protein that can help prepare your body for alcohol consumption. Protein slows down the emptying of the stomach. Eggs are another great option as well.
  • Fiber-Rich Foods: Vegetables like leafy greens, broccoli, and carrots are high in fiber. Fiber helps to regulate digestion and maintain a steady blood sugar level. Additionally, legumes such as beans, lentils, and chickpeas are excellent sources of both fiber and protein.
  • Fruits: Fruits like bananas, apples, and pears can be very beneficial to consume before drinking. Bananas are high in potassium, which helps balance electrolytes and can prevent dehydration. Apples and pears are rich in fiber and water content, which can help keep you hydrated and feeling full.
  • Dairy: Greek yogurt is high in protein and probiotics, making it a great food to consume before drinking. The protein in Greek yogurt can help slow alcohol absorption, while the probiotics can protect your stomach lining. Cheese also provides a good balance of protein and fat, which can create a protective layer in your stomach, slowing the alcohol absorption process.
  • Hydrating Foods: Foods with high water content, such as cucumbers and watermelon, can help maintain your hydration levels.
  • Snacks: A balanced snack like hummus and vegetables can be a great choice before drinking. Hummus provides protein and healthy fats, while vegetables offer fiber and hydration. Another good snack option is air-popped popcorn, which is a whole grain and low in calories. This can be a light yet filling snack that helps slow down alcohol absorption without adding excess fat or salt to your diet.

Eating these foods can help mitigate some of the negative effects of alcohol consumption, though it’s always best to drink responsibly.

Monitor Blood Sugar Levels

It’s important to regularly monitor your blood sugar levels, as alcohol can cause fluctuations that might be more pronounced when taking Wegovy. Additionally, keep emergency supplies like glucose tablets or a quick source of sugar on hand in case your blood sugar drops too low, ensuring you can address any issues promptly.

Monitoring blood sugar levels can be achieved through various methods and devices designed to make the process easier and more efficient. Here are some options:

  • Continuous Glucose Monitors (CGMs): CGMs are devices that provide real-time glucose readings throughout the day and night. They consist of a small sensor inserted under the skin and a transmitter that sends data to a display device, such as a smartphone or a dedicated monitor. Popular CGMs include Dexcom G6 and Freestyle Libre.
  • Smartphone-Compatible Glucose Meters: These devices connect to your smartphone via Bluetooth or a dedicated app, allowing you to track and manage your blood sugar levels conveniently. Examples include OneTouch Verio Flex and Accu-Chek Guide.
  • Traditional Glucometers: Although less high-tech, traditional glucometers are still widely used and can be very convenient. Examples include Freestyle Lite and iHealth Align.
  • Smartwatches and Fitness Trackers: Some smartwatches and fitness trackers now include glucose monitoring capabilities or can be paired with CGMs for continuous monitoring. Examples include Apple Watch and Fitbit.

Ask your healthcare provider to determine the best monitoring system for your needs.

Manage Nausea

Natural remedies like ginger and peppermint can be effective in alleviating nausea. Additionally, eating small, frequent meals throughout the day can help manage nausea, ensuring you maintain adequate nutrition and comfort.

Medications like Pepto-Bismol can also help with nausea, but it’s important to check for any interactions with alcohol or other medications you may be taking. Consult with your healthcare provider to ensure it’s appropriate for your situation.

Seek Medical Advice

If you experience significant side effects or have concerns about alcohol consumption while taking Wegovy, it is essential to speak with your healthcare provider. They can offer tailored guidance, address your worries, and modify your treatment plan if needed to ensure your safety and health.

Emergency Plan

Be aware of the symptoms of low blood sugar, such as dizziness, shakiness, sweating, and confusion. Recognizing these signs early can help you take prompt action. Carry a source of fast-acting carbohydrates, like glucose tablets, in case you need to raise your blood sugar quickly. Additionally, ensure you have a plan in place for seeking medical assistance in case of an emergency, including having emergency contacts readily available.

Drinking alcohol while on Wegovy requires careful consideration and moderation. Always consult your healthcare provider for personalized advice, monitor your body’s reactions, and follow these tips to safely enjoy alcohol without compromising your health or the effectiveness of your treatment.

Insights on Wegovy and Alcohol from Reddit

Alcohol on Wegovy
byu/bearlylove inWegovyWeightLoss

In the Reddit thread on Wegovy and alcohol, users share a variety of personal experiences and advice.

Here are some key points from the discussion:

  • Immediate Side Effects: Some users, like NormalVariety7215, report severe sickness, pain, and pain around ribs and back after consuming wine, particularly with fatty foods.
  • Delayed Reaction: AnyGood821 initially experienced no changes but later found alcohol caused fullness, stomach discomfort, and diarrhea, leading to a decreased desire for alcohol.
  • Avoidance and Adjustments: Users like bearlylove decided to skip alcohol to focus on healthier habits and weight loss, while others, like Historical_Wealth_74, noted nausea a few hours after drinking, despite enjoying the taste.
  • Loss of Cravings: Many users, such as Shadewolf82, lost their cravings for alcohol entirely, with some expressing relief at this change.

Overall, the consensus is to exercise caution and consider individual reactions, with many opting to reduce or eliminate alcohol consumption while on Wegovy.

Bottom Line

While you can drink alcohol while taking Wegovy, it is essential to do so with caution. Pay close attention to your body’s response and adjust your consumption accordingly. Always keep your alcohol intake within recommended limits to minimize potential interactions and side effects.

Additionally, it’s crucial to consult your healthcare provider for personalized advice, as individual health conditions and medication responses can vary. By staying informed and vigilant, you can safely navigate the combination of alcohol and Wegovy, ensuring both the effectiveness of your treatment and your overall well-being.

Frequently Asked Questions

Can you drink wine on Wegovy?

Yes, you can drink wine while taking Wegovy, but it is essential to do so in moderation. The recommended amount is up to 5 ounces of wine per day for women and up to 10 ounces for men.

What medicine can you not drink alcohol on?

Certain medications can have dangerous interactions with alcohol. These include, but are not limited to, anticoagulants like warfarin, antibiotics like metronidazole, antidepressants, antipsychotics, benzodiazepines, opioids, and some over-the-counter medications like acetaminophen. Always check with your healthcare provider or pharmacist regarding alcohol consumption when taking any medication.

What is the recommended amount of alcohol to consume while taking Wegovy?

Individual tolerance can vary, and it is best to consult your healthcare provider for personalized advice. As a general guideline, it’s advisable to limit alcohol consumption to one drink per day for women and two drinks per day for men. A single drink is equivalent to 5 ounces of wine, 12 ounces of beer, or 1.5 ounces of distilled spirits, to be enjoyed as part of your regular meal plan.

Are there certain types of alcohol that are considered safer to drink when using Wegovy?

There is no specific type of alcohol that is considered safer to drink while using Wegovy. The key is moderation and being mindful of how alcohol affects your blood sugar levels and overall health. Wine, beer, and spirits all have similar risks when consumed in excess.

How does the quantity or frequency of alcohol consumption impact the effectiveness of Wegovy?

Excessive alcohol consumption can negatively impact the effectiveness of Wegovy by interfering with your weight loss goals and potentially causing fluctuations in blood sugar levels. Regular heavy drinking can also increase the risk of side effects and complications, making it harder for Wegovy to work effectively.

Are there any significant case studies related to the use of alcohol and Wegovy?

Currently, there are limited specific case studies focusing on the use of alcohol and Wegovy. Most recommendations are based on general principles of medication and alcohol interactions, as well as clinical experience. It’s important to follow guidance from your healthcare provider based on your individual health profile.

What are the potential risks associated with binge drinking while on Wegovy?

Binge drinking while on Wegovy can increase the risk of severe side effects, including pancreatitis, liver damage, and hypoglycemia. It can also undermine the medication’s effectiveness in promoting weight loss and managing appetite.

Do people generally reduce their alcohol consumption when taking Wegovy?

Some people may naturally reduce their alcohol consumption when taking Wegovy due to the medication’s appetite-suppressing effects and the desire to maximize weight loss results. However, individual experiences can vary.

What non-alcoholic beverages can I choose instead of alcohol?

Non-alcoholic beverage options include sparkling water, herbal teas, non-alcoholic beers and wines, kombucha, flavored seltzers, and mocktails made with fruit juices and herbs. These options can provide a satisfying alternative to alcoholic drinks.

What are the best alcoholic beverages to consume while on Wegovy?

If you choose to drink alcohol while on Wegovy, it’s best to stick to lower-calorie options and consume them in moderation. Light beer, dry wine, and spirits mixed with low-calorie mixers (like soda water or diet tonic) are preferable choices. Always be mindful of portion sizes and overall consumption.

Can drinking alcohol interfere with weight loss efforts while taking Wegovy?

Yes, drinking alcohol can interfere with weight loss efforts while taking Wegovy. Alcoholic beverages can be high in calories and may reduce your willpower to stick to a healthy diet. Additionally, alcohol can affect metabolism and lead to poor food choices, hindering weight loss progress.


Chari, S., Teyssen, S., & Singer, M. V. (1993). Alcohol and gastric acid secretion in humans. Gut, 34(6), 843–847. https://doi.org/10.1136/gut.34.6.843

Banerjee N. (2014). Neurotransmitters in alcoholism: A review of neurobiological and genetic studies. Indian journal of human genetics, 20(1), 20–31. https://doi.org/10.4103/0971-6866.132750

Costardi, J. V., Nampo, R. A., Silva, G. L., Ribeiro, M. A., Stella, H. J., Stella, M. B., & Malheiros, S. V. (2015). A review on alcohol: from the central action mechanism to chemical dependency. Revista da Associacao Medica Brasileira (1992), 61(4), 381–387. https://doi.org/10.1590/1806-9282.61.04.381

Grad, S., Abenavoli, L., & Dumitrascu, D. L. (2016). The Effect of Alcohol on Gastrointestinal Motility. Reviews on recent clinical trials, 11(3), 191–195. https://doi.org/10.2174/1574887111666160815103251

Tasnim, S., Tang, C., Musini, V. M., & Wright, J. M. (2020). Effect of alcohol on blood pressure. The Cochrane database of systematic reviews, 7(7), CD012787. https://doi.org/10.1002/14651858.CD012787.pub2

FDA. (2023). HIGHLIGHTS OF PRESCRIBING INFORMATION OF WEGOVY. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/215256s007lbl.pdf#page=6.77