Wegovy and Zepbound are two distinct weight-loss medications. They both help people who are overweight or obese and have health issues because of their weight. But they work in various ways.

Wegovy (semaglutide) is an injectable medication for long-term weight management. The active ingredient, semaglutide, is effective in promoting weight loss. The FDA approved it in 2021, and it has helped many people lose weight.

Zepbound is also a medication you inject and contains an ingredient called tirzepatide.

Even though both medications aim to help with weight loss, they have some differences. So, if you’re thinking about using one of these medications to help you lose weight, it’s important to understand how they work and which one might be better for you.

Key Takeaways

  • Wegovy and Zepbound are not interchangeable; both medications are FDA-approved for weight loss but have different active ingredients, manufacturers, mechanisms of action, and dosing regimens.
  • Zepbound may provide greater weight loss results compared to Wegovy, but factors such as medical history, side effects, and cost should influence the choice between the two.
  • Patients typically use one Wegovy pen per week, requiring four pens for a monthly supply.
  • Combining Wegovy and Zepbound is not recommended due to the potential risk of interactions and adverse effects.
  • The effects of Zepbound can be noticeable as early as four weeks into treatment, with clinical trials indicating its effectiveness over approximately 16.5 months.
  • Weight regain is common after discontinuing weight loss treatments like Zepbound, highlighting the importance of long-term treatment for sustainable weight loss management.
  • It is essential to consult a healthcare provider to decide the most suitable medication based on individual health needs and goals.

Main Differences between Wegovy vs Zepbound

The main differences between Wegovy and Zepbound lie in their approved age groups, potential weight loss outcomes, and additional health benefits.

Both medications are meant to be used alongside a reduced-calorie diet and increased physical activity to aid in weight management.

Here is a comprehensive overview of the differences between Wegovy and Zepbound:

Key ComponentsWegovyZepbound
Generic nameSemaglutideTirzepatide
Forms and strengths
  • The injection comes in a clear, colorless solution.
  • Available in 5 pre-filled, disposable, single-dose pens.
    • 0.25 mg/0.5 mL
    • 0.5 mg/0.5 mL
    • 1 mg/0.5 mL
    • 1.7 mg/0.75 mL
    • 2.4 mg/0.75 mL
  • Injection available in various strengths:
    • 2.5 mg,
    • 5 mg,
    • 7.5 mg,
    • 10 mg,
    • 12.5 mg, or
    • 15 mg per 0.5 mL.
  • Comes in a single-dose pen or single-dose vial.
Dosage frequency
  • Administer Wegovy once weekly, on the same day each week, with or without meals.
  • Start with a dosage of 0.25 mg injected subcutaneously once weekly and follow the dose increase schedule to minimize gastrointestinal adverse reactions. If patients do not tolerate a dose during dosage escalation, consider delaying dosage escalation for 4 weeks.
  • Start with 2.5 mg once weekly and increase to 5 mg after 4 weeks.
  • Increase by 2.5 mg every 4 weeks.
  • Maintenance dosage: 5 mg, 10 mg, or 15 mg once weekly.
  • Maximum dosage: 15 mg once weekly.
  • Administer once weekly, any time, with or without meals.
  • Inject in the abdomen, thigh, or upper arm, rotating sites.
Who is approved to take it?
  • It is approved for adults and adolescents aged 12 and older with obesity or overweight and weight-related health issues.
  • It is approved for adults with obesity or overweight and weight-related health conditions such as hypertension, dyslipidemia, type 2 diabetes mellitus, obstructive sleep apnea, or cardiovascular disease.
Side effects
  • Nausea
  • Stomach (abdomen) pain
  • Dizziness
  • Gas
  • Diarrhea
  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Stomach (abdominal) pain

What is Wegovy (semaglutide)?

WegovyWegovy (semaglutide) is a medication you inject once a week, designed to help with weight loss. This hormone helps lower blood sugar levels and reduces appetite.

So, Wegovy not only helps with weight loss but also lowers the risk of heart problems like heart attacks or strokes in adults with known heart disease who are overweight or obese.

It’s important not to use Wegovy with other medications containing semaglutide or similar drugs. Some doctors were already prescribing Wegovy “off-label” for overweight or obese people with heart disease but no diabetes. Off-label means using a medication for a purpose not specifically approved by the FDA.

Now, with this official approval, more people might be able to get Wegovy prescribed by their doctors, which could mean better coverage by insurance companies for its cost.

Who qualifies for Wegovy?

Wegovy is FDA-approved for:

  • Adults and adolescents aged 12 and older who are classified as obese (BMI of 30 or greater) or overweight (BMI of 27 or greater) with one or more weight-related medical issues.
  • Adults with known heart disease who are overweight or obese, aim to reduce their risk of major cardiovascular events such as heart attacks or strokes.

How effective is Wegovy for weight loss?

Wegovy is effective for weight loss, according to a study. The study involved several trials where people who used Wegovy lost more weight compared to those who took a placebo or another similar medication called liraglutide.

This weight loss was significant and lasted for about 68 weeks. However, it’s not clear if losing this weight can reduce the chances of getting other health problems like type 2 diabetes or heart disease. Some people also experienced improvements in their quality of life, especially in their physical health.

But, it’s uncertain if this improvement is big enough to make a significant difference. It’s important to note that once people stopped taking Wegovy, they tended to gain back most of the weight they lost.

What is Zepbound (tirzepatide)?

Buy Zepbound Online from CanadaZepbound (tirzepatide) is a medication that you inject once a week to help you lose weight. It works by mimicking two important hormones in your body that help control blood sugar levels and reduce hunger.

However, note that it is not recommended for those with a history of pancreatitis or specific thyroid conditions.

Lastly, the safety and effectiveness of Zepbound for individuals under 18 have not been studied.

Who qualifies for Zepbound?

Zepbound is a medication you inject once a week to help adults lose weight if they’re very overweight or obese.

Qualifications for Zepbound:

  • It’s for adults who are very overweight or obese and have cardiovascular problems because of their weight.
  • You can use it if your doctor says your body mass index (BMI) is 30 or higher for obesity, or if it’s 27 or higher for overweight.

How Do Wegovy vs. Zepbound Mechanism Work?

Wegovy is a medication that mimics a single hormone in the body to aid in weight loss. In contrast, Zepbound has a dual function, mimicking two hormones that help regulate blood glucose levels and promote weight loss.

Both medications are designed for weekly administration, making them convenient options for individuals seeking weight management solutions.

Wegovy vs Zepbound on Weight Loss

In a study comparing two medications, tirzepatide and semaglutide, for treating type 2 diabetes, tirzepatide showed better results in lowering blood sugar levels and helping people lose weight.

The study involved almost 1900 patients who were given either tirzepatide or semaglutide for 40 weeks.

The results showed that tirzepatide, at different doses, was better than semaglutide in reducing the glycated hemoglobin level, which is a measure of blood sugar control.

Additionally, people who took tirzepatide lost more weight compared to those who took semaglutide.

The most common side effects of both medications were stomach-related issues like nausea, diarrhea, and vomiting, but they were mostly mild to moderate. However, serious side effects were reported in a small percentage of patients taking both medications.

In summary, the study found that tirzepatide (Zepbound) performed well in treating type 2 diabetes, outperforming semaglutide in reducing blood sugar levels and promoting weight loss over 40 weeks.

These results suggest that tirzepatide could be a valuable option for individuals with type 2 diabetes looking to manage blood sugar and weight.

More research is needed to evaluate the long-term safety and effectiveness of tirzepatide compared to current treatments.

Wegovy vs Zepbound Dosage

Both Wegovy and Zepbound are given as weekly injections but have different dosing schedules.

Wegovy starts at 0.25 mg per week and increases every four weeks to a maximum of 2.4 mg.

Zepbound starts at 2.5 mg per week, increases to 5 mg after four weeks, and then increases every four weeks up to a maximum of 15 mg per week.

Wegovy Forms and Dosages

Wegovy is available in various dosages and forms for convenient use. It comes in a clear, colorless solution administered through pre-filled, disposable, single-dose pens.

The available dosages and strengths include:

  • 0.25 mg/0.5 mL
  • 0.5 mg/0.5 mL
  • 1 mg/0.5 mL
  • 1.7 mg/0.75 mL
  • 2.4 mg/0.75 mL

These options allow for tailored treatment plans, starting with lower doses and gradually increasing as needed for effective weight management.

Zepbound Forms and Dosages

Zepbound is offered in various forms and dosages to suit individual needs. It is available as a clear, colorless slightly yellow solution in pre-filled single-dose pens or single-dose vials.

The available strengths include:

  • 2.5 mg/0.5 mL
  • 5 mg/0.5 mL
  • 7.5 mg/0.5 mL
  • 10 mg/0.5 mL
  • 12.5 mg/0.5 mL
  • 15 mg/0.5 mL

Wegovy vs Zepbound Side Effects

Wegovy and Zepbound may cause serious side effects, including inflammation of the pancreas, gallbladder problems, kidney issues, and allergic reactions.

Common side effects of both medications include nausea, stomach pain, diarrhea, vomiting, and constipation. Wegovy users may also experience dizziness, gas, headache, and tiredness, while Zepbound users may have injection site reactions, feel tired, or experience hair loss.

It’s essential to discuss any side effects with your healthcare provider.

Common Side Effects of Wegovy

  • Nausea
  • Stomach (abdomen) pain
  • Dizziness
  • Gas
  • Diarrhea
  • Headache
  • Feeling bloated
  • Stomach flu
  • Vomiting
  • Tiredness (fatigue)
  • Belching
  • Heartburn
  • Constipation
  • Upset stomach
  • Low blood sugar in people with type 2 diabetes
  • Runny nose or sore throat

Common Side Effects of Zepbound

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Stomach (abdominal) pain
  • Indigestion
  • Injection site reactions
  • Feeling tired
  • Allergic reactions
  • Belching
  • Hair loss
  • Heartburn

Rare Side Effects of Wegovy

While Wegovy typically presents common side effects, there are also severe side effects that may occur.

  • Inflammation of the pancreas (pancreatitis)
  • Gallbladder problems, including gallstones
  • Increased risk of low blood sugar (hypoglycemia)
  • Kidney problems, potentially leading to kidney failure
  • Serious allergic reactions
  • Change in vision in people with type 2 diabetes
  • Increased heart rate
  • Depression or thoughts of suicide

Rare Side Effects of Zepbound

Listed below are the severe side effects of Zepbound:

  • Severe stomach problems
  • Kidney problems, potentially leading to kidney failure
  • Gallbladder problems
  • Inflammation of the pancreas (pancreatitis)
  • Serious allergic reactions
  • Low blood sugar (hypoglycemia)
  • Changes in vision in patients with type 2 diabetes
  • Depression or thoughts of suicide

Drug Interactions with Wegovy vs. Zepbound

Both Wegovy and Zepbound have interactions with certain medications that users should be aware of, impacting their effectiveness and safety.

  • Simultaneous Use with Insulin or an Insulin Secretagogue: Wegovy lowers blood sugar levels and can increase the risk of hypoglycemia when used with insulin or insulin secretagogues like sulfonylureas. Similar to Wegovy, Zepbound also lowers blood sugar levels. It’s recommended to adjust the dose of insulin secretagogues or insulin when initiating Zepbound to reduce the risk of hypoglycemia.
  • Oral Medications: Wegovy may slow stomach emptying, impacting oral medication absorption. Though studies with semaglutide didn’t show significant effects on oral meds, monitoring is recommended when taken with Wegovy. Zepbound can also delay gastric emptying, affecting oral medication absorption. Patients using meds with a narrow therapeutic index, like warfarin, need close monitoring with Zepbound. Oral contraceptive users should follow healthcare provider advice on switching to non-oral methods or adding barrier contraception for specific durations.

Warning and Precautions for Wegovy and Zepbound

Both Wegovy and Zepbound come with important warnings and precautions to ensure safe usage.

Understanding these precautions is important for both patients and healthcare providers to reduce risks and achieve the best results.

  • Thyroid C-Cell Tumors: Both medications carry a potential risk of thyroid C-cell tumors, although it’s uncertain if they cause these tumors in humans. Patients with a history of thyroid tumors should avoid both Wegovy and Zepbound.
  • Acute Pancreatitis: Both medications have been associated with acute pancreatitis, a condition characterized by severe abdominal pain and vomiting. If these symptoms occur, discontinuing the medication and seeking medical help is crucial.
  • Acute Gallbladder Disease: Treatment with both Wegovy and Zepbound may increase the risk of gallbladder issues, which can manifest as upper stomach pain or jaundice.
  • Hypoglycemia: Both medications can lower blood sugar levels, leading to hypoglycemia, especially in patients on insulin or sulfonylureas. Regular monitoring of blood sugar levels is essential for patients using either medication.
  • Acute Kidney Injury: There have been reports of acute kidney injury associated with both Wegovy and Zepbound, particularly in patients with gastrointestinal side effects like nausea, vomiting, or diarrhea.
  • Hypersensitivity Reactions: Serious allergic reactions, including anaphylaxis and angioedema, have been reported with both medications. Patients with a history of such reactions should avoid using Wegovy or Zepbound.
  • Diabetic Retinopathy Complications: Rapid improvement in glucose control with either medication may temporarily worsen diabetic retinopathy. Patients with a history of diabetic retinopathy should be closely monitored.
  • Heart Rate Increase: Wegovy may increase resting heart rates, while data on Zepbound’s effects on heart rate are not available.
  • Suicidal Behavior and Ideation: Both medications have been associated with reports of suicidal behavior and ideation. Healthcare providers should monitor patients for changes in mood or behavior, especially those with a history of depression or suicidal thoughts.

Wegovy and Zepbound Cost

Wegovy and Zepbound differ in their cost and accessibility. While Wegovy offers discounts through the manufacturer’s website, its list price is $1,349.02 per month without insurance.

However, with insurance coverage, patients may pay as little as $25, depending on their insurance plans.

Additionally, Wegovy is available through PharmaGiant. This price applies to various strengths and quantities, including:

  • 1 mg/1.5 mL,
  • 2 mg/1.5 mL,
  • 4 mg/3 mL,
  • 6.8 mg/3 mL, and
  • 9.6 mg/3 mL

All of the aforementioned strengths are priced at $609.99 per pen.

Conversely, the cost of Zepbound subcutaneous solution (2.5 mg/0.5 mL) can be around $1,126 for a supply of 2 milliliters, though this may vary depending on the pharmacy.

These price differences may influence the choice between the two medications for individuals seeking weight management options.

Save Big on Weight Loss Medications

Buy Wegovy and Other Affordable Medications at Pharma Giant!

For unbeatable savings on weight loss medications like Wegovy, visit Pharma Giant. Enjoy express shipping across the US within 3-5 business days and use coupon code FIRST10 for additional savings on your first purchase.

With bulk discounts available, you can save up to 90% on your medication costs. Shop now and start your weight loss journey with Pharma Giant, your trusted online pharmacy partner.

Wegovy vs Zepbound: Which one is right for you?

When considering weight loss treatments, it’s essential to explore options like Zepbound and Wegovy, both approved by the FDA. While these medications share certain side effects, they differ significantly in their mechanisms of action within the body’s hormonal landscape.

Understanding these distinctions can help individuals make informed decisions about which medication might be the most suitable choice for their weight loss journey. Knowing what is right for you can lead to better success in reaching your goals and improving your overall health.

Who Can Prescribe Wegovy and Zepbound?

Wegovy and Zepbound can be prescribed by healthcare providers who are licensed to prescribe medications. This typically includes doctors, nurse practitioners, and physician assistants.

These healthcare professionals assess the patient’s medical history, overall health, and weight loss goals to determine if Wegovy or Zepbound is appropriate for them.

They also monitor the patient’s progress and any potential side effects while on the medication.

Frequently Asked Questions about Wegovy vs. Zepbound

How often is Wegovy taken?

Wegovy is usually taken once a week. This weekly dosing schedule makes it convenient for many people to incorporate into their routine. It’s important to follow the prescribed dosage and administration instructions provided by your healthcare provider. If you have any questions about how often to take Wegovy or any concerns about your treatment regimen, be sure to discuss them with your healthcare provider.

Are wegovy and zepbound interchangeable?

No, Wegovy and Zepbound are not interchangeable medications. While both are weight-loss drugs approved by the FDA, they are produced by different pharmaceutical companies and contain different active ingredients. Wegovy, manufactured by Novo Nordisk, and Zepbound, developed by Eli Lilly, have distinct formulations and mechanisms of action. Therefore, they should not be substituted for one another without consulting a healthcare professional.

When was Wegovy approved by the FDA?

Wegovy was approved by the FDA in June 2021. It is indicated for chronic weight management in adults with obesity or overweight, who also have at least one weight-related condition like high blood pressure, type 2 diabetes, or high cholesterol.

How are Wegovy and Zepbound different?

Wegovy and Zepbound are different medications despite both being FDA-approved for weight loss. They contain different active ingredients and may have different dosing regimens, side effects, and mechanisms of action.

How many Wegovy pens per month?

Typically, for a month’s supply of Wegovy, patients would use one pen per week. This means you would need four Wegovy pens for a month. However, for a three-month supply, which is often prescribed for appropriate patients, you would need three packs, each containing four Wegovy pens. So, for a three-month supply, patients would use twelve Wegovy pens in total.

Can Wegovy cause vertigo?

While vertigo is not a commonly reported side effect of Wegovy, it’s essential to recognize that medication side effects can vary from person to person. According to the data, only about 3% of approved medications for diabetes management list vertigo or spinning as reported side effects.

However, this information should not discourage individuals from seeking medical advice if they experience vertigo while taking Wegovy, as individual reactions can differ, and it’s essential to discuss any concerns with a healthcare provider.

Is Zepbound more effective than wegovy?

Zepbound may offer better weight loss than Wegovy, showing significant body weight reductions over time. If you need extra weight loss support, Zepbound could be considered. While Zepbound might be more effective, consider Wegovy for heart disease. Both are brand-name drugs with cost-saving options but remember not to use Zepbound just for cosmetic weight loss.

Can I take both Wegovy and Zepbound?

Combining Wegovy and Zepbound is not recommended due to potential interactions that could outweigh the benefits of either medication alone. Mixing these medications without proper medical supervision could lead to unforeseen complications or adverse effects.

How long until Zepbound works?

People typically begin to notice weight loss effects from Zepbound approximately four weeks after starting the medication. This duration allows the medication to reach consistent levels in the body. Zepbound’s clinical trial spanned 72 weeks, equivalent to approximately 16.5 months, providing insights into its long-term effectiveness.

Will I gain weight after stopping Zepbound?

Research indicates that weight regain often occurs after discontinuing weight loss treatments such as Zepbound. It’s important to note that many patients may require ongoing treatment to either sustain or enhance their current weight loss achievements. Thus, maintaining treatment with Zepbound could be essential for optimizing long-term weight management outcomes and preventing relapse.


In conclusion, both Wegovy and Zepbound offer promising avenues for weight loss management, each with its unique characteristics and considerations.

While Wegovy has been on the market longer and has demonstrated efficacy in clinical trials, Zepbound presents a newer option that may potentially yield greater weight loss results.

However, individual factors such as medical history, side effect profiles, and cost must be carefully evaluated when deciding between these medications.

Ultimately, consulting with a healthcare provider is crucial to determine the most suitable treatment approach for each individual’s weight loss journey.


LifeMD. (2023). ZepboundTM vs. Wegovy®  https://lifemd.com/learn/the-difference-between-zepbound-and-wegovy

GoodRx. (2024). Zepbound vs. Wegovy: 5 differences between these weight-loss medications. GoodRx.


Patel, R. (202). Zepbound vs Wegovy. NowPatient. https://nowpatient.com/blog/zepbound-vs-wegovy

Puddick, R. (2024). Zepbound vs Wegovy: Zepbound and Wegovy Reviews: Zepbound UK. Zepbound and Wegovy Reviews | Zepbound UK.


National Institutes of Health. (2024). DailyMed – Wegovy- semaglutide injection, solution. U.S. National Library of medication.


National Institutes of Health. (2024). DailyMed – zepbound- tirzepatide injection, solution zepbound- tirzepatide injection, solution. U.S. National Library of medication.


Katella, K. (2024). Why Your Cardiologist May Prescribe Semaglutide (Wegovy). Yale medication.


Tirzepatide (Zepbound) for chronic weight management. (2023). The Medical letter on drugs and therapeutics, 65(1692), 205–207. https://pubmed.ncbi.nlm.nih.gov/38133594/

Dong, S., & Sun, C. (2022). Can glucagon-like peptide-1 receptor agonists cause acute kidney injury? an analytical study based on post-marketing approval Pharmacovigilance Data. Frontiers in endocrinology.


Center for Drug Evaluation and Research. (2024). Update on FDA’s ongoing evaluation of GLP-1 Ras and Suicidality. U.S. Food and Drug Administration.


Drugs.com. (n.d.). Zepbound Prices, Coupons, Copay & Patient Assistance..


DiSogra, R. M., & Meece, J. (2019). Auditory and vestibular side effects of FDA-approved drugs for diabetes. Seminars in hearing.