Drugs like Mounjaro are becoming extremely popular due to their weight loss benefits. However, there’s increasing concern about its impact on skin appearance. “Mounjaro face” is a term commonly used to describe the loose or sagging skin that can occur with rapid weight loss from this medication.

As people lose weight quickly, their skin may not have enough time to adjust. This can lead to a less firm appearance, especially on the face. Similar to the effects experienced with other weight loss drugs, the skin might look wrinkly or less full due to the rapid reduction in fat tissue.

In this article, you will learn about Mounjaro’s effects on weight loss, including how it can affect the face. Additionally, we’ll explore the potential side effects of Mounjaro and discuss ways to manage them effectively.

Key Takeaways

  • Mounjaro, also known as tirzepatide, is a medication that has shown impressive weight loss results and is gaining popularity for its effectiveness in helping people lose weight. However, some users have reported changes in their facial appearance, which has been referred to as “Mounjaro Face.”
  • The medication mimics natural hormones in the body that regulate appetite and blood sugar levels. This reduces hunger and increases feelings of fullness, ultimately resulting in effective weight loss.
  • Rapid weight loss, a common effect of Mounjaro, can lead to changes in facial appearance, including the loss of fat in the face, which may cause the skin to appear looser and result in increased wrinkles and lines, particularly in individuals in their 40s and 50s.
  • While Mounjaro has been associated with significant weight loss, it may also cause side effects such as nausea, fatigue, and gastrointestinal issues. More serious side effects, including changes in vision and potential kidney and pancreas issues, are less common but require close monitoring.
  • To address potential facial side effects, individuals using Mounjaro are advised to stay hydrated, maintain a balanced diet rich in proteins, vitamins, and minerals, and consult their healthcare professional to discuss dosage adjustments or alternative treatments if the side effects are concerning.

Understanding Mounjaro

A man getting facial procedures done by his cosmetologist

Mounjaro, also known as tirzepatide, is a medication used to treat type 2 diabetes and is also used off-label to aid in weight loss. However, it is available under the brand name Zepbound as FDA-approved for weight loss. It works by mimicking two natural hormones in your body that regulate appetite and blood sugar levels, making you feel fuller for longer and reducing your hunger. This dual action helps you eat less and lose weight more effectively. Mounjaro has become very popular because it has shown impressive results in studies.

For example, some research has shown that Mounjaro (which contains tirzepatide) can significantly lower weight in people with obesity. In a study involving more than 2,500 adults with obesity, individuals taking 5 milligrams of Mounjaro for 72 weeks (approximately a year and a half) experienced an average weight loss of 15% of their body weight. Higher doses were associated with even more weight loss.

Additionally, the SURMOUNT-3 and SURMOUNT-4 trials conducted by Eli Lilly found that when taking tirzepatide (Mounjaro), patients with obesity experienced a remarkable 26.6% weight loss over the course of 84 weeks. This effectiveness has made it a go-to option for many looking to manage their weight more efficiently.

How Does Mounjaro Affect the Face?

Mounjaro affects how your body handles hunger and how it uses insulin, which helps lower blood sugar levels. Taking Mounjaro helps your pancreas release insulin more efficiently when your blood sugar is high. It also acts on your brain to make you feel fuller for longer periods, which leads to eating less and, as a result, losing weight.

This rapid weight loss is often seen first in the face and typically affects people in their 40s and 50s. The face loses fat, which can make your skin look looser and may increase wrinkles and lines. Normally, facial fat helps keep the skin stretched and smooth, so when this fat reduces quickly, the skin doesn’t have time to adjust, losing its elasticity.

This can give the face a more aged or hollowed-out appearance, which directly affects how Mounjaro leads to weight loss. This is what people mean when they talk about “Mounjaro face.”

Other Possible Side Effects of Mounjaro

Apart from facial changes due to weight loss while on this medication, Mounjaro may cause several side effects. Common side effects include nausea, feeling very tired (fatigue), and problems with the stomach and bowels, like vomiting, diarrhea, stomach ache, and constipation. These are typically mild but can be bothersome.

Apart from these, Mounjaro might also lead to more serious side effects, though these are less common. These can include changes in vision, kidney issues, severe stomach pain which could indicate pancreas inflammation, and serious allergic reactions. There’s also a concern about potential thyroid tumors, which makes regular medical check-ups crucial.

Because of these possible risks, it’s very important for anyone taking Mounjaro to do so under the close supervision of a healthcare professional. This ensures that any serious side effects are spotted early and managed properly. Always report any new or worsening symptoms to your doctor, as they can help decide if adjustments to the treatment or additional tests are needed.

Preventing Facial Side Effects

If you are using Mounjaro for diabetes or weight management and notice changes in your face, such as more wrinkles or sagging skin due to rapid weight loss, here are some tips to help reduce these facial side effects:

  • Stay Hydrated: Drinking plenty of water, around 1-2 liters a day, can help keep your skin hydrated and more elastic, which might reduce sagging and the appearance of wrinkles.
  • Nutritional Adjustments: Eating a balanced diet rich in proteins, vitamins, and minerals can support skin health. Proteins are especially important as they are the building blocks of skin tissue, including collagen and elastin, which help keep your skin firm and elastic.
  • Consult Your Doctor About Dosage: If the facial side effects are concerning, talk to your doctor. They might adjust your dosage or suggest how to take the medication to help minimize side effects.

If these changes don’t help or if the side effects are severe, there are alternative treatments you might consider:

  • Dermatological Treatments: Options like facial fillers can help restore the lost volume and reduce the appearance of sagging and wrinkles. Qualified professionals should do these.
  • Switching Medications: If Mounjaro’s side effects are too problematic, your doctor might suggest trying a different medication.
  • Lifestyle Modifications: Maintaining a healthy weight through a balanced diet and regular exercise can also help manage the severity of the side effects.

What Happens After Stopping Mounjaro?

When someone stops taking Mounjaro, a medicine used mainly for diabetes and weight management, they might notice a few changes. First, the weight they lost while using Mounjaro might start to come back. This is because the effects that made them feel less hungry and slowed down their digestion, helping them eat less, will no longer be active. This can lead to an increase in appetite, causing them to eat more, which may lead to weight gain.

Also, the changes in the face associated with rapid weight loss, sometimes referred to as “Mounjaro face,” such as thinning or sagging skin, might gradually lessen as the weight is regained. This is because as the body regains fat, some of it will redistribute back to the face, potentially filling out some of the areas that appear more hollow or saggy.

Final Thoughts

In conclusion, Mounjaro has shown remarkable effectiveness in aiding weight loss for individuals with obesity. However, it’s crucial to be aware of the potential side effects, including the impact on facial appearance due to rapid weight loss. While these effects can be concerning, they can be managed with the guidance of a healthcare professional. It’s important to stay vigilant about any changes in your health while using Mounjaro and to communicate openly with your doctor about any concerns.

Furthermore, it’s essential to consider the long-term implications of using Mounjaro and to have a plan for transitioning off the medication if necessary. Healthy lifestyle modifications, including a balanced diet and regular exercise, should be integrated into the overall approach to weight management, and alternative treatments should be explored if the side effects of Mounjaro become too burdensome.

Remember, every individual’s response to medication can vary, so it’s important to work closely with healthcare professionals to determine the best course of action for your specific needs.

FAQs About Mounjaro

Does Mounjaro cause face changes?

Mounjaro (tirzepatide) has been reported to cause facial changes in some users. Weight loss can reduce facial fat, which may result in a more gaunt or aged appearance. However, these changes vary widely among individuals and depend on lost weight.

Does Mounjaro make your face puffy?

Mounjaro does not typically cause facial puffiness. In fact, due to weight loss, some users may experience reduced facial fat, making the face appear slimmer rather than puffy.

What are the long-term effects of Mounjaro?

The long-term effects of Mounjaro are still being studied, but it has been shown to significantly aid in weight loss and improve glycemic control in patients with type 2 diabetes. Potential long-term side effects may include gastrointestinal issues, pancreatitis, and gallbladder problems.

Does Mounjaro make your face look old?

Mounjaro can lead to weight loss, which might reduce facial fat. This loss can make the face appear older or more gaunt. The degree of this effect varies among individuals and is influenced by the amount of weight lost and individual skin elasticity.

How much weight can you lose on Mounjaro?

Clinical studies have shown that patients can lose significant weight on Mounjaro. On average, users have reported weight loss of up to 22.5% of their body weight over 72 weeks. However, individual results can vary.

Has Mounjaro been approved for weight loss?

Currently, Mounjaro has been approved by the FDA for treating type 2 diabetes, but it has not yet received specific approval for weight loss. However, it has been noted for its significant weight loss benefits, and further studies are underway to expand its indications potentially.


Eli Lilly and Company. (2023, July 27). Tirzepatide demonstrated significant and superior weight loss compared to placebo in two pivotal studies. PR Newswire. https://investor.lilly.com/news-releases/news-release-details/tirzepatide-demonstrated-significant-and-superior-weight-loss

Wharton, S., Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Connery, L., Alves, B., Kiyosue, A., Zhang, S., Liu, B., Bunck, M. C., & Stefanski, A. (2022, June 4). Tirzepatide Once Weekly for the Treatment of Obesity. New England Journal of Medicine, 387(3), 205-216.https://www.nejm.org/doi/full/10.1056/NEJMoa2206038